Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Agap2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AGAP2
- Mouse genes Agap2
- Rat genes Agap2
- Zfish genes agap2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Agap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	AGAP2	IDA		Human	PMID:11136977
Molecular Function	GO:0005525	GTP binding	AGAP2	IDA		Human	PMID:11136977
Molecular Function	GO:0005525	GTP binding	AGAP2	IDA		Human	PMID:12640130
Molecular Function	GO:0005096	GTPase activator activity	AGAP2	IDA		Human	PMID:1238857
Molecular Function	GO:0003924	GTPase activity	AGAP2	IDA		Human	PMID:11136977
Molecular Function	GO:0003924	GTPase activity	AGAP2	IDA		Human	PMID:12640130
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	AGAP2	IDA		Human	PMID:11136977
Molecular Function	GO:0005515	protein binding	AGAP2	IPI	UniProtKB:P06213	Human	PMID:21720388
Molecular Function	GO:0005515	protein binding	Agap2	IPI	PR:Q08501	Mouse	PMID:20075866
Molecular Function	GO:0005515	protein binding	Agap2	IPI	PR:P42230	Mouse	PMID:20075866
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:Q9Z214-1	Rat	PMID:14528310\|RGD:1299350
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:O08722	Rat	PMID:18469807\|RGD:8553892
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:Q63155	Rat	PMID:18469807\|RGD:8553892
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:Q8IZJ1	Rat	PMID:18469807\|RGD:8553892
Molecular Function	GO:0005515	protein binding	Agap2	IPI	Rgd:621667	Rat	PMID:21847098\|RGD:8553599
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:P19491	Rat	PMID:21847098\|RGD:8553599
Molecular Function	GO:0005515	protein binding	Agap2	IPI	UniProtKB:P97879	Rat	PMID:21847098\|RGD:8553599
Molecular Function	GO:0030295	protein kinase activator activity	AGAP2	IDA		Human	PMID:14761976
Molecular Function	GO:0030295	protein kinase activator activity	Agap2	IDA		Rat	PMID:11136977\|RGD:632423
Molecular Function	GO:0019901	protein kinase binding	AGAP2	IDA		Human	PMID:14761976
Molecular Function	GO:0019901	protein kinase binding	Agap2	IDA		Rat	PMID:11136977\|RGD:632423
Molecular Function	GO:0044877	protein-containing complex binding	Agap2	IPI	Rgd:621667,Rgd:61862	Rat	PMID:21847098\|RGD:8553599
Cellular Component	GO:0005737	cytoplasm	AGAP2	IDA		Human	PMID:14761976
Cellular Component	GO:0005829	cytosol	AGAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Agap2	IDA		Rat	PMID:21847098\|RGD:8553599
Cellular Component	GO:0005768	endosome	AGAP2	IDA		Human	PMID:12388557
Cellular Component	GO:0009897	external side of plasma membrane	Agap2	IDA		Rat	PMID:21847098\|RGD:8553599
Cellular Component	GO:0070062	extracellular exosome	AGAP2	HDA		Human	PMID:18570454
Cellular Component	GO:0090543	Flemming body	AGAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098978	glutamatergic synapse	Agap2	IEP		Mouse	PMID:28706196
Cellular Component	GO:0098978	glutamatergic synapse	Agap2	IDA		Mouse	PMID:28706196
Cellular Component	GO:0098978	glutamatergic synapse	Agap2	IPI		Mouse	PMID:28706196
Cellular Component	GO:0016020	membrane	AGAP2	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	AGAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	AGAP2	IDA		Human	PMID:14761976
Cellular Component	GO:0005634	nucleus	Agap2	IDA		Rat	PMID:11136977\|RGD:632423
Cellular Component	GO:0098794	postsynapse	Agap2	IDA		Mouse	PMID:28706196
Cellular Component	GO:0098794	postsynapse	Agap2	IEP		Mouse	PMID:28706196
Cellular Component	GO:0098794	postsynapse	Agap2	IPI		Mouse	PMID:28706196
Biological Process	GO:0030036	actin cytoskeleton organization	AGAP2	IDA		Human	PMID:12388557
Biological Process	GO:0006915	apoptotic process	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:1905430	cellular response to glycine	Agap2	IDA		Rat	PMID:21847098\|RGD:8553599
Biological Process	GO:0016197	endosomal transport	AGAP2	IDA		Human	PMID:12388557
Biological Process	GO:1904019	epithelial cell apoptotic process	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0007507	heart development	agap2	IMP	ZFIN:ZDB-MRPHLNO-191002-1,ZFIN:ZDB-MRPHLNO-191002-2	Zfish	PMID:25739401
Biological Process	GO:0060749	mammary gland alveolus development	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Agap2	IGI	MGI:MGI:88313	Mouse	PMID:20075866
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0043066	negative regulation of apoptotic process	Agap2	IMP		Mouse	PMID:16841086
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Agap2	IMP		Rat	PMID:18469807\|RGD:8553892
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	AGAP2	IGI	UniProtKB:Q01105	Human	PMID:18374643
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	AGAP2	IGI	UniProtKB:Q99538	Human	PMID:18374643
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Agap2	IMP		Rat	PMID:14528310\|RGD:1299350
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Agap2	IMP		Rat	PMID:18469807\|RGD:8553892
Biological Process	GO:0042177	negative regulation of protein catabolic process	AGAP2	IDA		Human	PMID:18374643
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Agap2	IGI	MGI:MGI:88313	Mouse	PMID:20075866
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	Agap2	IMP		Mouse	PMID:20075866
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Agap2	IMP		Rat	PMID:21847098\|RGD:8553599
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Agap2	IMP		Rat	PMID:14528310\|RGD:1299350
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Agap2	IMP		Rat	PMID:18469807\|RGD:8553892
Biological Process	GO:0045860	positive regulation of protein kinase activity	AGAP2	IDA		Human	PMID:14761976
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Agap2	IMP		Rat	PMID:21847098\|RGD:8553599
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Agap2	IMP		Mouse	PMID:20075866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Agap2	IMP		Mouse	PMID:20075866
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Agap2	IMP	MGI:MGI:4439325	Mouse	PMID:20075866
Biological Process	GO:0001944	vasculature development	agap2	IMP	ZFIN:ZDB-MRPHLNO-191002-1,ZFIN:ZDB-MRPHLNO-191002-2	Zfish	PMID:25739401

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.