Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGER
  • Mouse genes Ager
  • Rat genes Ager
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ager

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	AGER	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:22406537
Molecular Function	GO:0001540	amyloid-beta binding	AGER	IPI	UniProtKB:P05067	Human	PMID:23973487
Molecular Function	GO:0001540	amyloid-beta binding	AGER	IDA		Human	PMID:29518356
Molecular Function	GO:0070379	high mobility group box 1 binding	Ager	IPI	RGD:2802	Rat	PMID:22740883|RGD:7245517
Molecular Function	GO:0042802	identical protein binding	AGER	IPI	UniProtKB:Q15109	Human	PMID:24119142
Molecular Function	GO:0060090	molecular adaptor activity	AGER	EXP		Human	PMID:22194616
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P25815	Human	PMID:16061848
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P02766	Human	PMID:16716307
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P00533	Human	PMID:16954185
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q01279	Human	PMID:16954185
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P04271	Human	PMID:17660747
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P04271	Human	PMID:17726019
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:O60610	Human	PMID:18922799
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P80511	Human	PMID:19386136
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P61586	Human	PMID:19944695
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P58753	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q05513	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P09429	Human	PMID:24474694
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q8IW41	Human	PMID:26758977
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q96FZ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q8N108-16	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AGER	IPI	UniProtKB:Q8WU43	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:Q02956	Mouse	MGI:MGI:6189240|PMID:21829704
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:P05067	Mouse	MGI:MGI:4398766|PMID:19901339
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:P79105	Mouse	MGI:MGI:1339508|PMID:10399917
Molecular Function	GO:0005515	protein binding	Ager	IPI	PR:Q6S5I3	Mouse	PMID:21148126
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:P04631	Rat	PMID:19910580|RGD:2325647
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:P35467	Rat	PMID:19910580|RGD:2325647
Molecular Function	GO:0005515	protein binding	Ager	IPI	RGD:1310883	Rat	PMID:23164356|RGD:7244287
Molecular Function	GO:0005515	protein binding	Ager	IPI	RGD:1584013	Rat	PMID:23164356|RGD:7244287
Molecular Function	GO:0005515	protein binding	Ager	IPI	RGD:2802	Rat	PMID:7592757|RGD:68739
Molecular Function	GO:0005515	protein binding	Ager	IPI	UniProtKB:P63159	Rat	PMID:7592757|RGD:68739
Molecular Function	GO:0044877	protein-containing complex binding	AGER	IPI	ComplexPortal:CPX-1120	Human	PMID:29518356
Molecular Function	GO:0044548	S100 protein binding	AGER	IPI	UniProtKB:P04271	Human	PMID:15033494
Molecular Function	GO:0044548	S100 protein binding	AGER	IPI	UniProtKB:P26447	Human	PMID:15033494
Molecular Function	GO:0044548	S100 protein binding	AGER	IPI	UniProtKB:P80511	Human	PMID:15033494
Molecular Function	GO:0044548	S100 protein binding	AGER	IPI	UniProtKB:Q99584	Human	PMID:15033494
Molecular Function	GO:0044548	S100 protein binding	Ager	IPI	UniProtKB:P31151	Mouse	MGI:MGI:4441248|PMID:18606705
Molecular Function	GO:0044548	S100 protein binding	Ager	IPI	RGD:3615	Rat	PMID:19910580|RGD:2325647
Molecular Function	GO:0038023	signaling receptor activity	AGER	IMP		Human	PMID:15457210
Cellular Component	GO:0016324	apical plasma membrane	AGER	IDA		Human	PMID:26005850
Cellular Component	GO:0030424	axon	Ager	IDA		Rat	PMID:7592757|RGD:68739
Cellular Component	GO:0009925	basal plasma membrane	Ager	IDA		Rat	PMID:9846897|RGD:1625351
Cellular Component	GO:0030054	cell junction	AGER	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Ager	IDA		Rat	PMID:17959934|RGD:7244241
Cellular Component	GO:0005737	cytoplasm	Ager	IDA		Rat	PMID:18849572|RGD:2325655
Cellular Component	GO:0005829	cytosol	Ager	IDA		Rat	PMID:21704028|RGD:7244186
Cellular Component	GO:0005615	extracellular space	Ager	IDA		Rat	PMID:16456142|RGD:1625343
Cellular Component	GO:0001650	fibrillar center	AGER	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	Ager	IDA		Rat	PMID:7592757|RGD:68739
Cellular Component	GO:0005886	plasma membrane	AGER	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Ager	IDA		Rat	PMID:18849572|RGD:2325655
Biological Process	GO:0048143	astrocyte activation	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0014002	astrocyte development	Ager	IMP		Mouse	PMID:22577135
Biological Process	GO:0007420	brain development	Ager	IEP		Rat	PMID:7592757|RGD:68739
Biological Process	GO:0055074	calcium ion homeostasis	Ager	IMP		Rat	PMID:19589269|RGD:2325648
Biological Process	GO:1904646	cellular response to amyloid-beta	Ager	IMP		Mouse	MGI:MGI:6114835|PMID:19221410
Biological Process	GO:0071398	cellular response to fatty acid	Ager	IEP		Rat	PMID:22217518|RGD:7245568
Biological Process	GO:0071333	cellular response to glucose stimulus	Ager	IEP		Rat	PMID:20054520|RGD:7244147
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Ager	IEP		Rat	PMID:19885844|RGD:7244243
Biological Process	GO:0071407	cellular response to organic cyclic compound	Ager	IEP		Rat	PMID:21807062|RGD:7245956
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Ager	IEP		Rat	PMID:22467055|RGD:7245559
Biological Process	GO:0010255	glucose mediated signaling pathway	AGER	IDA		Human	PMID:25689357
Biological Process	GO:0009100	glycoprotein metabolic process	Ager	IEP		Rat	PMID:23348924|RGD:7244269
Biological Process	GO:0050930	induction of positive chemotaxis	Ager	IMP		Mouse	PMID:14744997
Biological Process	GO:0006954	inflammatory response	Ager	IGI	MGI:MGI:2687194	Mouse	PMID:21148126
Biological Process	GO:0006954	inflammatory response	Ager	IGI	MGI:MGI:104798	Mouse	PMID:21148126
Biological Process	GO:0007611	learning or memory	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0030324	lung development	Ager	IEP		Rat	PMID:17343756|RGD:1625339
Biological Process	GO:0001774	microglial cell activation	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0001774	microglial cell activation	Ager	IGI	UniProtKB:P05067	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:1903523	negative regulation of blood circulation	Ager	IGI	UniProtKB:P05067:PRO_0000000093,UniProtKB:P22387|UniProtKB:P12023:PRO_0000000119,UniProtKB:P22387	Mouse	MGI:MGI:6271381|PMID:12808450
Biological Process	GO:0007162	negative regulation of cell adhesion	Ager	IMP		Rat	PMID:22301267|RGD:7245563
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Ager	IMP		Rat	PMID:21872885|RGD:7245949
Biological Process	GO:0010596	negative regulation of endothelial cell migration	Ager	IMP		Rat	PMID:22301267|RGD:7245563
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	Ager	IMP		Rat	PMID:22301267|RGD:7245563
Biological Process	GO:0032693	negative regulation of interleukin-10 production	AGER	IDA		Human	PMID:22473704
Biological Process	GO:1900453	negative regulation of long-term synaptic depression	AGER	IGI	ComplexPortal:CPX-1134	Human	PMID:20739563
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Ager	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:6094326|PMID:18367618
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	Ager	IEP		Rat	PMID:23529231|RGD:7244256
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Ager	IMP		Rat	PMID:21743278|RGD:7243870
Biological Process	GO:0031175	neuron projection development	AGER	IGI	UniProtKB:P63159	Human	PMID:10391939
Biological Process	GO:0031175	neuron projection development	Ager	IGI	UniProtKB:P63159	Rat	PMID:7592757|RGD:68739
Biological Process	GO:0031175	neuron projection development	Ager	IMP		Rat	PMID:7592757|RGD:68739
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	AGER	IMP		Human	PMID:15944249
Biological Process	GO:0043065	positive regulation of apoptotic process	Ager	IMP		Rat	PMID:19910580|RGD:2325647
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	AGER	IGI	UniProtKB:P05067:PRO_0000000093	Human	PMID:22406537
Biological Process	GO:0010508	positive regulation of autophagy	Ager	IMP		Rat	PMID:22293957|RGD:7245565
Biological Process	GO:0030335	positive regulation of cell migration	Ager	IMP		Rat	PMID:19380826|RGD:2325649
Biological Process	GO:0032722	positive regulation of chemokine production	Ager	IGI	UniProtKB:P05067	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	AGER	IMP		Human	PMID:15944249
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	Ager	IMP		Rat	PMID:22301267|RGD:7245563
Biological Process	GO:1904472	positive regulation of endothelin production	Ager	IGI	UniProtKB:P05067:PRO_0000000093|UniProtKB:P12023:PRO_0000000119	Mouse	MGI:MGI:6271381|PMID:12808450
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Ager	IMP		Rat	PMID:21743278|RGD:7243870
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0010763	positive regulation of fibroblast migration	Ager	IMP		Rat	PMID:19959167|RGD:2325646
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Ager	IMP		Rat	PMID:23053478|RGD:7244384
Biological Process	GO:0010628	positive regulation of gene expression	Ager	IMP		Rat	PMID:21111711|RGD:7244240
Biological Process	GO:0010628	positive regulation of gene expression	Ager	IMP		Rat	PMID:21743278|RGD:7243870
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	AGER	IGI	UniProtKB:P13612,UniProtKB:P19320	Human	PMID:11078691
Biological Process	GO:0050729	positive regulation of inflammatory response	Ager	IMP		Rat	PMID:19959167|RGD:2325646
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Ager	IGI	UniProtKB:P05067	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:0032735	positive regulation of interleukin-12 production	AGER	IMP		Human	PMID:15944249
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ager	IGI	UniProtKB:P05067	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:0046330	positive regulation of JNK cascade	AGER	IGI	ComplexPortal:CPX-1134,UniProtKB:P10749	Human	PMID:20739563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Ager	IMP	MGI:MGI:2451038	Mouse	PMID:18323529
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	Ager	IGI	UniProtKB:P02638	Mouse	PMID:24995813
Biological Process	GO:2000439	positive regulation of monocyte extravasation	AGER	IMP		Human	PMID:11078691
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Ager	IMP		Rat	PMID:22717618|RGD:7245531
Biological Process	GO:1901216	positive regulation of neuron death	Ager	IMP		Rat	PMID:22415896|RGD:7245561
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	AGER	IDA		Human	PMID:10391939
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	AGER	IGI	ComplexPortal:CPX-1134,UniProtKB:P10749	Human	PMID:20739563
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Ager	IMP		Rat	PMID:23238794|RGD:8696010
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	Ager	IMP		Rat	PMID:23212096|RGD:7244285
Biological Process	GO:0001934	positive regulation of protein phosphorylation	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ager	IMP		Rat	PMID:19885844|RGD:7244243
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Ager	IMP		Rat	PMID:19885844|RGD:7244243
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Ager	IMP		Rat	PMID:23212096|RGD:7244285
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ager	IMP		Rat	PMID:16368901|RGD:1625344
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ager	IMP		Rat	PMID:23212096|RGD:7244285
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ager	IGI	UniProtKB:P05067	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	Ager	IMP		Rat	PMID:21111711|RGD:7244240
Biological Process	GO:0072657	protein localization to membrane	Ager	IMP	MGI:MGI:2451038	Mouse	PMID:18323529
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Ager	IMP		Rat	PMID:11180401|RGD:1625349
Biological Process	GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	AGER	IDA		Human	PMID:22473704
Biological Process	GO:0051101	regulation of DNA binding	Ager	IMP	MGI:MGI:2451038	Mouse	PMID:18323529
Biological Process	GO:0050727	regulation of inflammatory response	Ager	IDA		Mouse	MGI:MGI:1339508|PMID:10399917
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Ager	IMP		Mouse	MGI:MGI:6114835|PMID:19221410
Biological Process	GO:1900744	regulation of p38MAPK cascade	Ager	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:6094326|PMID:18367618
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	AGER	IGI	UniProtKB:P05067	Human	PMID:15457210
Biological Process	GO:0001914	regulation of T cell mediated cytotoxicity	AGER	IDA		Human	PMID:22473704
Biological Process	GO:0014823	response to activity	Ager	IEP		Rat	PMID:23285277|RGD:7244282
Biological Process	GO:1904645	response to amyloid-beta	Ager	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:6094326|PMID:18367618
Biological Process	GO:0009750	response to fructose	Ager	IEP		Rat	PMID:21704028|RGD:7244186
Biological Process	GO:0033595	response to genistein	Ager	IEP		Rat	PMID:21704028|RGD:7244186
Biological Process	GO:0055093	response to hyperoxia	Ager	IEP		Rat	PMID:17343756|RGD:1625339
Biological Process	GO:0001666	response to hypoxia	Ager	IMP	MGI:MGI:2451038	Mouse	PMID:18323529
Biological Process	GO:0051595	response to methylglyoxal	Ager	IEP		Rat	PMID:22425979|RGD:7245560
Biological Process	GO:0072714	response to selenite ion	Ager	IEP		Rat	PMID:22476978|RGD:7245558
Biological Process	GO:0033189	response to vitamin A	Ager	IEP		Rat	PMID:22274401|RGD:7245566
Biological Process	GO:0045056	transcytosis	Ager	IGI	UniProtKB:P05067:PRO_0000000092|UniProtKB:P05067:PRO_0000000093	Mouse	MGI:MGI:5424311|PMID:22406537
Biological Process	GO:0045056	transcytosis	Ager	IMP		Mouse	MGI:MGI:6271381|PMID:12808450
Biological Process	GO:0060290	transdifferentiation	Ager	IEP		Rat	PMID:23403079|RGD:7244262
Biological Process	GO:0150104	transport across blood-brain barrier	AGER	IDA		Human	PMID:23973487

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern