Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGO1
  • Mouse genes Ago1
  • Rat genes Ago1
  • Zfish genes ago1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ago1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	AGO1	IMP		Human	PMID:25336585
Molecular Function	GO:0003725	double-stranded RNA binding	AGO1	IDA		Human	PMID:19966796
Molecular Function	GO:0035198	miRNA binding	AGO1	IDA		Human	PMID:15260970
Molecular Function	GO:0035198	miRNA binding	Ago1	IDA		Mouse	PMID:22053081
Molecular Function	GO:0035198	miRNA binding	Ago1	IDA		Mouse	PMID:23185045
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UPY3	Human	PMID:12526743
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9HCE1	Human	PMID:16289642
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UKV8	Human	PMID:16756390
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UPQ9-2	Human	PMID:17891150
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P08238	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P11940	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P17844	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P43243	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P52597	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P67809	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q12906	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q15020	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q15717	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q16531	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q7L2E3	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q92900	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9H0S4	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9H2U1	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9NZI8	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UPY3	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P04156	Human	PMID:18482256
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:O15397	Human	PMID:19167051
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q8NDV7	Human	PMID:19324964
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q8NDV7	Human	PMID:19383768
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UPQ9-2	Human	PMID:19383768
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q8NDV7	Human	PMID:19716330
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UPY3	Human	PMID:19716330
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:A6NIX2	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q96IF1	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UGP4	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P04156	Human	PMID:22484317
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q8NDV7	Human	PMID:22484317
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q6NTF7	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q8IUX4	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9HC16	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P08238	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P20226	Human	PMID:25336585
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:P53041	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	AGO1	IPI	UniProtKB:Q9UGP4	Human	PMID:28683311
Molecular Function	GO:0005515	protein binding	Ago1	IPI	UniProtKB:Q8CH72	Mouse	MGI:MGI:3836317|PMID:19269368
Molecular Function	GO:0003723	RNA binding	AGO1	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	AGO1	IDA		Human	PMID:23809764
Molecular Function	GO:0003723	RNA binding	Ago1	IDA		Mouse	PMID:19536157
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Ago1	IDA		Mouse	PMID:22053081
Molecular Function	GO:0000993	RNA polymerase II complex binding	AGO1	IDA		Human	PMID:25336585
Molecular Function	GO:0003727	single-stranded RNA binding	AGO1	IDA		Human	PMID:19966796
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Ago1	IMP		Mouse	MGI:MGI:5494393|PMID:22053081
Cellular Component	GO:0005737	cytoplasm	AGO1	IDA		Human	PMID:15260970
Cellular Component	GO:0005737	cytoplasm	AGO1	IDA		Human	PMID:20014101
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	AGO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	AGO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ago1	IDA		Mouse	PMID:22053081
Cellular Component	GO:0005634	nucleus	Ago1	IDA		Mouse	PMID:22053081
Cellular Component	GO:0000932	P-body	Ago1	IDA		Mouse	PMID:19898466
Cellular Component	GO:0005844	polysome	AGO1	IDA		Human	PMID:17932509
Cellular Component	GO:1990904	ribonucleoprotein complex	AGO1	IDA		Human	PMID:17932509
Cellular Component	GO:0016442	RISC complex	AGO1	IDA		Human	PMID:15260970
Cellular Component	GO:0016442	RISC complex	AGO1	IDA		Human	PMID:17932509
Cellular Component	GO:0016442	RISC complex	AGO1	IDA		Human	PMID:19966796
Cellular Component	GO:0016442	RISC complex	Ago1	IDA		Mouse	PMID:19536157
Cellular Component	GO:0070578	RISC-loading complex	AGO1	IDA		Human	PMID:19966796
Biological Process	GO:0010586	miRNA metabolic process	Ago1	IDA		Mouse	PMID:22053081
Biological Process	GO:0035196	miRNA processing	AGO1	IMP		Human	PMID:22795694
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	AGO1	IDA		Human	PMID:18771919
Biological Process	GO:0016525	negative regulation of angiogenesis	AGO1	IMP		Human	PMID:23426184
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	AGO1	IDA		Human	PMID:18771919
Biological Process	GO:0010628	positive regulation of gene expression	Ago1	IMP		Mouse	MGI:MGI:5788605|PMID:26764146
Biological Process	GO:0010628	positive regulation of gene expression	Ago1	IMP		Mouse	PMID:22053081
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Ago1	IMP		Mouse	MGI:MGI:5788605|PMID:26764146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	AGO1	IMP		Human	PMID:25336585
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ago1	IMP		Mouse	MGI:MGI:5494393|PMID:22053081
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ago1	IDA		Mouse	PMID:22053081
Biological Process	GO:0031054	pre-miRNA processing	AGO1	IDA		Human	PMID:19966796
Biological Process	GO:0070922	RISC complex assembly	AGO1	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO1	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO1	IMP		Human	PMID:22795694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern