Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGO3
  • Mouse genes Ago3
  • Rat genes Ago3
  • Zfish genes ago3a,ago3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ago3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	AGO3	IDA		Human	PMID:19966796
Molecular Function	GO:0090624	endoribonuclease activity, cleaving miRNA-paired mRNA	AGO3	IMP		Human	PMID:29040713
Molecular Function	GO:0035198	miRNA binding	AGO3	IDA		Human	PMID:15260970
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:O15397	Human	PMID:19167051
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q8NDV7	Human	PMID:19324964
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q8NDV7	Human	PMID:19383768
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q6NTF7	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q8IUX4	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q9HC16	Human	PMID:22915799
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q6P2E9	Human	PMID:23064648
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:P53041	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:A6NIX2	Human	PMID:28683311
Molecular Function	GO:0005515	protein binding	AGO3	IPI	UniProtKB:Q8NDV7	Human	PMID:28683311
Molecular Function	GO:0003723	RNA binding	AGO3	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	AGO3	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	Ago3	IDA		Mouse	PMID:19536157
Molecular Function	GO:0004521	RNA endonuclease activity	AGO3	IMP		Human	PMID:29040713
Molecular Function	GO:0003727	single-stranded RNA binding	AGO3	IDA		Human	PMID:19966796
Cellular Component	GO:0000794	condensed nuclear chromosome	Ago3	IDA		Mouse	PMID:22863743
Cellular Component	GO:0005737	cytoplasm	AGO3	IDA		Human	PMID:15260970
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	AGO3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	AGO3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	AGO3	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	AGO3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016442	RISC complex	AGO3	IDA		Human	PMID:15260970
Cellular Component	GO:0016442	RISC complex	AGO3	IDA		Human	PMID:19966796
Cellular Component	GO:0016442	RISC complex	Ago3	IDA		Mouse	PMID:19536157
Cellular Component	GO:0070578	RISC-loading complex	AGO3	IDA		Human	PMID:19966796
Biological Process	GO:0035196	miRNA processing	AGO3	IMP		Human	PMID:22795694
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	AGO3	IDA		Human	PMID:18771919
Biological Process	GO:0006402	mRNA catabolic process	AGO3	IDA		Human	PMID:18771919
Biological Process	GO:0010628	positive regulation of gene expression	Ago3	IMP		Mouse	MGI:MGI:5788605|PMID:26764146
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Ago3	IMP		Mouse	MGI:MGI:5788605|PMID:26764146
Biological Process	GO:0031054	pre-miRNA processing	AGO3	IDA		Human	PMID:19966796
Biological Process	GO:0072091	regulation of stem cell proliferation	AGO3	IMP		Human	PMID:23064648
Biological Process	GO:0070922	RISC complex assembly	AGO3	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO3	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO3	IMP		Human	PMID:22795694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern