Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGRN
  • Mouse genes Agrn
  • Rat genes Agrn
  • Zfish genes agrn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Agrn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030548	acetylcholine receptor regulator activity	Agrn	IDA		Mouse	PMID:14622576
Molecular Function	GO:0042030	ATPase inhibitor activity	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Molecular Function	GO:0036122	BMP binding	Agrn	IPI	RGD:730832	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0036122	BMP binding	Agrn	IPI	RGD:733110	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0005509	calcium ion binding	Agrn	IDA		Rat	PMID:20566625|RGD:8553952
Molecular Function	GO:0035374	chondroitin sulfate binding	Agrn	IDA		Mouse	MGI:MGI:5486565|PMID:12773545
Molecular Function	GO:0002162	dystroglycan binding	Agrn	IDA		Rat	PMID:8693000|RGD:8553979
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Agrn	IDA		Mouse	MGI:MGI:5486565|PMID:12773545
Molecular Function	GO:0005515	protein binding	AGRN	IPI	UniProtKB:O15265	Human	PMID:21078624
Molecular Function	GO:0005515	protein binding	AGRN	IPI	UniProtKB:Q14118	Human	PMID:9417121
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:Q8VI56	Mouse	MGI:MGI:5545965|PMID:21969364
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:P06687	Rat	PMID:16630822|RGD:8553868
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:Q8VI56	Rat	PMID:18848351|RGD:8553831
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:Q9QYP1	Rat	PMID:18957220|RGD:10047261
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:P01137	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:P12643	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:P12644	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:Q9QYP1	Rat	PMID:22302937|RGD:8553690
Molecular Function	GO:0005515	protein binding	Agrn	IPI	RGD:628843	Rat	PMID:25151458|RGD:13204806
Molecular Function	GO:0005515	protein binding	Agrn	IPI	UniProtKB:Q28685	Rat	PMID:8205617|RGD:8554634
Molecular Function	GO:0050431	transforming growth factor beta binding	Agrn	IPI	RGD:69095	Rat	PMID:20505824|RGD:8549766
Molecular Function	GO:0044325	transmembrane transporter binding	Agrn	IPI	UniProtKB:Q6PIC6	Mouse	MGI:MGI:4352602|PMID:19376779
Cellular Component	GO:0044295	axonal growth cone	Agrn	IDA		Rat	PMID:14697677|RGD:8549767
Cellular Component	GO:0005604	basement membrane	AGRN	IDA		Human	PMID:9405491
Cellular Component	GO:0005604	basement membrane	Agrn	IDA		Mouse	PMID:7670489
Cellular Component	GO:0005604	basement membrane	Agrn	IDA		Mouse	PMID:18757743
Cellular Component	GO:0005604	basement membrane	Agrn	IDA		Rat	PMID:15711988|RGD:1578369
Cellular Component	GO:0009986	cell surface	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	IDA		Human	PMID:17628813
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	AGRN	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Agrn	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0070062	extracellular exosome	AGRN	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	AGRN	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	AGRN	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Agrn	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Agrn	IDA		Mouse	PMID:12165471
Cellular Component	GO:0005615	extracellular space	Agrn	IDA		Mouse	PMID:9422725
Cellular Component	GO:0098978	glutamatergic synapse	Agrn	IDA		Rat	PMID:19524020|RGD:13702171
Cellular Component	GO:0098978	glutamatergic synapse	Agrn	IMP		Rat	PMID:19524020|RGD:13702171
Cellular Component	GO:0042383	sarcolemma	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Cellular Component	GO:0045202	synapse	Agrn	IDA		Mouse	PMID:18230682
Cellular Component	GO:0045202	synapse	Agrn	IDA		Mouse	PMID:16635246
Cellular Component	GO:0045202	synapse	Agrn	EXP		Mouse	PMID:16635246
Cellular Component	GO:0045202	synapse	Agrn	IDA		Rat	PMID:12796478|RGD:8554671
Cellular Component	GO:0043083	synaptic cleft	Agrn	IDA		Mouse	MGI:MGI:5464044|PMID:23056392
Biological Process	GO:0009952	anterior/posterior pattern specification	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-2	Zfish	PMID:17110391
Biological Process	GO:0009952	anterior/posterior pattern specification	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-1	Zfish	PMID:17110391
Biological Process	GO:0007409	axonogenesis	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-1	Zfish	PMID:17110391
Biological Process	GO:0007409	axonogenesis	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-2	Zfish	PMID:17110391
Biological Process	GO:0007417	central nervous system development	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-2	Zfish	PMID:17110391
Biological Process	GO:0007417	central nervous system development	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-1	Zfish	PMID:17110391
Biological Process	GO:0007268	chemical synaptic transmission	Agrn	IDA		Mouse	PMID:8653788
Biological Process	GO:0007268	chemical synaptic transmission	Agrn	IMP		Rat	PMID:15883200|RGD:1578368
Biological Process	GO:0097049	motor neuron apoptotic process	Agrn	IMP	MGI:MGI:1929777	Mouse	PMID:11312299
Biological Process	GO:1903407	negative regulation of P-type sodium:potassium-exchanging transporter activity	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Biological Process	GO:1903277	negative regulation of sodium ion export across plasma membrane	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Biological Process	GO:0007528	neuromuscular junction development	Agrn	IGI	MGI:MGI:94941	Mouse	PMID:12165471
Biological Process	GO:0007528	neuromuscular junction development	Agrn	IGI	MGI:MGI:103581	Mouse	PMID:12165471
Biological Process	GO:0007528	neuromuscular junction development	Agrn	IGI	MGI:MGI:1339975	Mouse	PMID:12165471
Biological Process	GO:0045213	neurotransmitter receptor metabolic process	Agrn	IDA		Mouse	PMID:14622576
Biological Process	GO:0007422	peripheral nervous system development	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-1	Zfish	PMID:17110391
Biological Process	GO:0007422	peripheral nervous system development	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-2	Zfish	PMID:17110391
Biological Process	GO:0007009	plasma membrane organization	Agrn	IMP	MGI:MGI:1929777	Mouse	PMID:8653788
Biological Process	GO:0051491	positive regulation of filopodium assembly	Agrn	IDA		Rat	PMID:20471381|RGD:8554517
Biological Process	GO:0043547	positive regulation of GTPase activity	Agrn	IDA		Rat	PMID:20471381|RGD:8554517
Biological Process	GO:2000673	positive regulation of motor neuron apoptotic process	Agrn	IMP	MGI:MGI:1929777	Mouse	PMID:11312299
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Agrn	IDA		Rat	PMID:18957220|RGD:10047261
Biological Process	GO:0032092	positive regulation of protein binding	Agrn	IDA		Mouse	MGI:MGI:5545965|PMID:21969364
Biological Process	GO:2000541	positive regulation of protein geranylgeranylation	Agrn	IMP		Mouse	MGI:MGI:2680892|PMID:14622576
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Agrn	IDA		Mouse	MGI:MGI:2680892|PMID:14622576
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Agrn	IMP		Rat	PMID:22302937|RGD:8553690
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Biological Process	GO:0045887	positive regulation of synaptic assembly at neuromuscular junction	Agrn	IMP		Mouse	MGI:MGI:1337916|PMID:10402191
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Agrn	IDA		Mouse	PMID:9422725
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Agrn	IDA		Rat	PMID:12796478|RGD:8554671
Biological Process	GO:0015031	protein transport	Agrn	IDA		Mouse	PMID:24753587
Biological Process	GO:0043113	receptor clustering	AGRN	IDA		Human	PMID:15340048
Biological Process	GO:0043113	receptor clustering	AGRN	IMP		Human	PMID:9151673
Biological Process	GO:0043113	receptor clustering	Agrn	IGI	MGI:MGI:94941	Mouse	PMID:12165471
Biological Process	GO:0043113	receptor clustering	Agrn	IGI	MGI:MGI:103581	Mouse	PMID:12165471
Biological Process	GO:0043113	receptor clustering	Agrn	IGI	MGI:MGI:1339975	Mouse	PMID:12165471
Biological Process	GO:0043113	receptor clustering	Agrn	IDA		Mouse	PMID:17119023
Biological Process	GO:0043113	receptor clustering	Agrn	IDA		Mouse	PMID:11018052
Biological Process	GO:0043113	receptor clustering	Agrn	IMP	MGI:MGI:1929777	Mouse	PMID:11395002
Biological Process	GO:0043113	receptor clustering	Agrn	IDA		Rat	PMID:15155732|RGD:8554357
Biological Process	GO:1902667	regulation of axon guidance	Agrn	IDA		Rat	PMID:17870250|RGD:2304008
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Biological Process	GO:0055117	regulation of cardiac muscle contraction	Agrn	IDA		Mouse	MGI:MGI:4352602|PMID:19376779
Biological Process	GO:0043087	regulation of GTPase activity	Agrn	IDA		Mouse	MGI:MGI:2680892|PMID:14622576
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	Agrn	IDA		Rat	PMID:17870250|RGD:2304008
Biological Process	GO:0001932	regulation of protein phosphorylation	Agrn	IDA		Rat	PMID:18848351|RGD:8553831
Biological Process	GO:0050807	regulation of synapse organization	Agrn	IDA		Rat	PMID:19524020|RGD:13702171
Biological Process	GO:0050807	regulation of synapse organization	Agrn	IMP		Rat	PMID:19524020|RGD:13702171
Biological Process	GO:0060025	regulation of synaptic activity	Agrn	IDA		Mouse	PMID:24753587
Biological Process	GO:0010842	retina layer formation	agrn	IMP	ZFIN:ZDB-MRPHLNO-070411-2	Zfish	PMID:21308976
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Agrn	IDA		Rat	PMID:18957220|RGD:10047261
Biological Process	GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Agrn	IMP		Rat	PMID:22302937|RGD:8553690
Biological Process	GO:0007416	synapse assembly	Agrn	IMP		Rat	PMID:12486121|RGD:1578367

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern