Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGTR1
  • Mouse genes Agtr1a
  • Rat genes Agtr1a
  • Zfish genes agtr1a,agtr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Agtr1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:10993080
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IPI	UniProtKB:P01019	Human	PMID:1378723
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:15611106
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:25913193
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:26420482
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:30639100
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:32079768
Molecular Function	GO:0001596	angiotensin type I receptor activity	AGTR1	IDA		Human	PMID:8987975
Molecular Function	GO:0001596	angiotensin type I receptor activity	Agtr1a	IDA		Mouse	PMID:12657564
Molecular Function	GO:0001596	angiotensin type I receptor activity	Agtr1a	IDA		Rat	PMID:10747880|RGD:152025503
Molecular Function	GO:0001596	angiotensin type I receptor activity	Agtr1a	IDA		Rat	PMID:11906170|RGD:70819
Molecular Function	GO:0001596	angiotensin type I receptor activity	Agtr1a	IDA		Rat	PMID:2041570|RGD:152025523
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR1	IDA		Human	PMID:1567413
Molecular Function	GO:0031711	bradykinin receptor binding	AGTR1	IPI	UniProtKB:P30411	Human	PMID:10993080
Molecular Function	GO:0031748	D1 dopamine receptor binding	Agtr1a	IPI	RGD:2518	Rat	PMID:22193384|RGD:7248445
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P01019	Human	PMID:1378723
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P32121	Human	PMID:15611106
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P49407	Human	PMID:15611106
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P41495	Human	PMID:19023134
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P35414	Human	PMID:21412239
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P35414	Human	PMID:22935142
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P01019:PRO_0000032458	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P21333	Human	PMID:26460884
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:O75937	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P05026	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:P54368	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	AGTR1	IPI	UniProtKB:Q6ZMG9	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	UniProtKB:Q9WVK0	Mouse	MGI:MGI:1338561|PMID:10358057
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	RGD:1310385	Rat	PMID:14559250|RGD:2316188
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	RGD:2521	Rat	PMID:16902178|RGD:1581469
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	UniProtKB:P01019	Rat	PMID:18202720|RGD:8553626
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	UniProtKB:P30994	Rat	PMID:19023134|RGD:8554388
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	RGD:2157	Rat	PMID:19522833|RGD:5509965
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	RGD:620574	Rat	PMID:21376054|RGD:5129173
Molecular Function	GO:0005515	protein binding	Agtr1a	IPI	UniProtKB:P21333	Rat	PMID:26460884|RGD:10680029
Molecular Function	GO:0046982	protein heterodimerization activity	AGTR1	IPI	UniProtKB:P30411	Human	PMID:10993080
Molecular Function	GO:0019901	protein kinase binding	Agtr1a	IPI	RGD:2939	Rat	PMID:9287353|RGD:5133683
Molecular Function	GO:0019901	protein kinase binding	Agtr1a	IPI	RGD:2320469	Rat	PMID:9314843|RGD:6478796
Molecular Function	GO:0019901	protein kinase binding	Agtr1a	IPI	RGD:2939	Rat	PMID:9314843|RGD:6478796
Cellular Component	GO:0016323	basolateral plasma membrane	Agtr1a	IDA		Rat	PMID:12110004|RGD:1626500
Cellular Component	GO:0005737	cytoplasm	Agtr1a	IDA		Mouse	PMID:15499027
Cellular Component	GO:0031410	cytoplasmic vesicle	Agtr1a	IDA		Rat	PMID:14559250|RGD:2316188
Cellular Component	GO:0030425	dendrite	Agtr1a	IDA		Rat	PMID:15590154|RGD:1579760
Cellular Component	GO:0012505	endomembrane system	Agtr1a	IDA		Rat	PMID:15590154|RGD:1579760
Cellular Component	GO:0005768	endosome	Agtr1a	IDA		Mouse	PMID:14718562
Cellular Component	GO:0005794	Golgi apparatus	Agtr1a	IDA		Rat	PMID:14559250|RGD:2316188
Cellular Component	GO:0016020	membrane	Agtr1a	IDA		Rat	PMID:12446719|RGD:629553
Cellular Component	GO:0031968	organelle outer membrane	Agtr1a	IDA		Rat	PMID:15590154|RGD:1579760
Cellular Component	GO:0005886	plasma membrane	AGTR1	IDA		Human	PMID:19023134
Cellular Component	GO:0005886	plasma membrane	AGTR1	IDA		Human	PMID:33713620
Cellular Component	GO:0005886	plasma membrane	Agtr1a	IDA		Mouse	PMID:15499027
Cellular Component	GO:0005886	plasma membrane	Agtr1a	IDA		Mouse	PMID:14718562
Cellular Component	GO:0005886	plasma membrane	Agtr1a	IDA		Rat	PMID:14559250|RGD:2316188
Cellular Component	GO:0005886	plasma membrane	Agtr1a	IDA		Rat	PMID:19023134|RGD:8554388
Cellular Component	GO:0055037	recycling endosome	Agtr1a	IDA		Rat	PMID:14559250|RGD:2316188
Biological Process	GO:0042976	activation of Janus kinase activity	Agtr1a	IMP		Rat	PMID:9314843|RGD:6478796
Biological Process	GO:0007568	aging	Agtr1a	IEP		Rat	PMID:21318332|RGD:5129178
Biological Process	GO:0038166	angiotensin-activated signaling pathway	AGTR1	IDA		Human	PMID:1567413
Biological Process	GO:0038166	angiotensin-activated signaling pathway	Agtr1a	IMP		Rat	PMID:21769867|RGD:5688337
Biological Process	GO:0001568	blood vessel development	Agtr1a	IGI	MGI:MGI:87965	Mouse	PMID:9466969
Biological Process	GO:0002035	brain renin-angiotensin system	Agtr1a	IMP		Mouse	PMID:16585392
Biological Process	GO:0002035	brain renin-angiotensin system	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:10880053
Biological Process	GO:0019722	calcium-mediated signaling	AGTR1	IDA		Human	PMID:1567413
Biological Process	GO:0060326	cell chemotaxis	AGTR1	IDA		Human	PMID:15635042
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Agtr1a	IDA		Rat	PMID:17537984|RGD:1643596
Biological Process	GO:0042416	dopamine biosynthetic process	Agtr1a	IMP		Rat	PMID:20097214|RGD:6903884
Biological Process	GO:0042756	drinking behavior	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:10880053
Biological Process	GO:0042756	drinking behavior	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:12167595
Biological Process	GO:0042756	drinking behavior	Agtr1a	IGI	MGI:MGI:87965	Mouse	PMID:10880053
Biological Process	GO:0042756	drinking behavior	Agtr1a	IMP		Rat	PMID:9622148|RGD:8549458
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AGTR1	IDA		Human	PMID:1378723
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Agtr1a	IMP		Rat	PMID:12446719|RGD:629553
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Agtr1a	IMP		Rat	PMID:9092554|RGD:1582440
Biological Process	GO:0010467	gene expression	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:24206662
Biological Process	GO:0007507	heart development	Agtr1a	IMP		Mouse	PMID:16585392
Biological Process	GO:0006954	inflammatory response	Agtr1a	IGI	MGI:MGI:87966	Mouse	PMID:19404405
Biological Process	GO:0006954	inflammatory response	Agtr1a	IGI	MGI:MGI:87965	Mouse	PMID:19404405
Biological Process	GO:0001822	kidney development	AGTR1	IMP		Human	PMID:16116425
Biological Process	GO:0001822	kidney development	Agtr1a	IGI	MGI:MGI:87965	Mouse	PMID:9466969
Biological Process	GO:0001822	kidney development	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:12167595
Biological Process	GO:0002034	maintenance of blood vessel diameter homeostasis by renin-angiotensin	AGTR1	IDA		Human	PMID:25913193
Biological Process	GO:0002034	maintenance of blood vessel diameter homeostasis by renin-angiotensin	AGTR1	IDA		Human	PMID:26420482
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	Agtr1a	IMP		Mouse	PMID:19508861
Biological Process	GO:0051402	neuron apoptotic process	Agtr1a	IMP		Mouse	PMID:9310306
Biological Process	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	AGTR1	IDA		Human	PMID:1378723
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Agtr1a	IDA		Rat	PMID:11906170|RGD:70819
Biological Process	GO:0045766	positive regulation of angiogenesis	Agtr1a	IMP		Rat	PMID:32324784|RGD:127345089
Biological Process	GO:0045777	positive regulation of blood pressure	Agtr1a	IGI	MGI:MGI:94925	Mouse	PMID:9691085
Biological Process	GO:0045777	positive regulation of blood pressure	Agtr1a	IDA		Mouse	PMID:12486173
Biological Process	GO:0045777	positive regulation of blood pressure	Agtr1a	IMP		Mouse	PMID:12486173
Biological Process	GO:0045777	positive regulation of blood pressure	Agtr1a	IMP		Rat	PMID:20702798|RGD:5147459
Biological Process	GO:0045777	positive regulation of blood pressure	Agtr1a	IMP		Rat	PMID:21769867|RGD:5688337
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	AGTR1	IGI	RNAcentral:URS0000338542_9606	Human	PMID:25850724
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Agtr1a	IMP		Rat	PMID:17537984|RGD:1643596
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	Agtr1a	IMP		Rat	PMID:15569855|RGD:1579758
Biological Process	GO:0008284	positive regulation of cell population proliferation	Agtr1a	IMP		Rat	PMID:22645419|RGD:6903871
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	AGTR1	IMP		Human	PMID:18971559
Biological Process	GO:0001819	positive regulation of cytokine production	Agtr1a	IMP		Mouse	MGI:MGI:4420536|PMID:19023134
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	AGTR1	IDA		Human	PMID:1567413
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	AGTR1	IDA		Human	PMID:1567413
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	AGTR1	IMP		Human	PMID:18971559
Biological Process	GO:0032430	positive regulation of phospholipase A2 activity	AGTR1	IMP		Human	PMID:17069818
Biological Process	GO:0051247	positive regulation of protein metabolic process	AGTR1	IMP		Human	PMID:18971559
Biological Process	GO:0001921	positive regulation of receptor recycling	Agtr1a	IDA		Rat	PMID:14559250|RGD:2316188
Biological Process	GO:0032930	positive regulation of superoxide anion generation	Agtr1a	IMP		Rat	PMID:21076237|RGD:5129195
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:19508861
Biological Process	GO:0008217	regulation of blood pressure	Agtr1a	IMP		Mouse	PMID:26531127
Biological Process	GO:0006885	regulation of pH	Agtr1a	IDA		Rat	PMID:11906170|RGD:70819
Biological Process	GO:0002019	regulation of renal output by angiotensin	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:12167595
Biological Process	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	Agtr1a	IGI	MGI:MGI:87965	Mouse	PMID:9466969
Biological Process	GO:1905459	regulation of vascular associated smooth muscle cell apoptotic process	Agtr1a	IGI	MGI:MGI:2384310	Mouse	PMID:19508861
Biological Process	GO:0019229	regulation of vasoconstriction	AGTR1	IDA		Human	PMID:15117835
Biological Process	GO:0002001	renin secretion into blood stream	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:12167595
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:12167595
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	Agtr1a	IMP		Rat	PMID:21318332|RGD:5129178
Biological Process	GO:0014823	response to activity	Agtr1a	IEP		Rat	PMID:18252761|RGD:10047108
Biological Process	GO:1990776	response to angiotensin	Agtr1a	IEP		Rat	PMID:8986922|RGD:10047122
Biological Process	GO:0051412	response to corticosterone	Agtr1a	IEP		Rat	PMID:7594440|RGD:10047392
Biological Process	GO:0043627	response to estrogen	Agtr1a	IDA		Rat	PMID:12810582|RGD:1598880
Biological Process	GO:0043627	response to estrogen	Agtr1a	IEP		Rat	PMID:15544836|RGD:2317723
Biological Process	GO:0009651	response to salt stress	Agtr1a	IEP		Rat	PMID:9095078|RGD:10047102
Biological Process	GO:0007266	Rho protein signal transduction	AGTR1	IDA		Human	PMID:15611106
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Agtr1a	IMP	MGI:MGI:1857147	Mouse	PMID:19508861
Biological Process	GO:0042310	vasoconstriction	Agtr1a	IMP		Rat	PMID:20955746|RGD:5129197
Biological Process	GO:0046718	viral entry into host cell	AGTR1	IDA		Human	PMID:33713620

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern