Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGTR2
  • Mouse genes Agtr2
  • Rat genes Agtr2
  • Zfish genes agtr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Agtr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR2	IPI	UniProtKB:P01019	Human	PMID:10406457
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR2	IDA		Human	PMID:28379944
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR2	IDA		Human	PMID:29967536
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR2	IDA		Human	PMID:31899086
Molecular Function	GO:0004945	angiotensin type II receptor activity	AGTR2	IDA		Human	PMID:32669569
Molecular Function	GO:0004945	angiotensin type II receptor activity	Agtr2	IDA		Mouse	PMID:9878677
Molecular Function	GO:0004945	angiotensin type II receptor activity	Agtr2	IPI	UniProtKB:P11859	Mouse	PMID:9878677
Molecular Function	GO:0004945	angiotensin type II receptor activity	Agtr2	IDA		Rat	PMID:8227011|RGD:152025531
Molecular Function	GO:0005515	protein binding	AGTR2	IPI	UniProtKB:P01019	Human	PMID:10406457
Molecular Function	GO:0005515	protein binding	AGTR2	IPI	UniProtKB:P35625	Human	PMID:18344519
Molecular Function	GO:0005515	protein binding	AGTR2	IPI	UniProtKB:P01019:PRO_0000032459	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	Agtr2	IPI	RGD:2201	Rat	PMID:16754789|RGD:1625043
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Agtr2	IDA		Rat	PMID:14657020|RGD:1566502
Cellular Component	GO:0005886	plasma membrane	Agtr2	IDA		Rat	PMID:14657020|RGD:1566502
Biological Process	GO:0035932	aldosterone secretion	Agtr2	IMP		Rat	PMID:1566502|RGD:6903876
Biological Process	GO:0002033	angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	Agtr2	IMP	MGI:MGI:1857123	Mouse	PMID:10425188
Biological Process	GO:0002035	brain renin-angiotensin system	Agtr2	IDA		Mouse	PMID:9878677
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Agtr2	IMP		Rat	PMID:21173078|RGD:6903878
Biological Process	GO:0007166	cell surface receptor signaling pathway	AGTR2	IDA		Human	PMID:10406457
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Agtr2	IDA		Rat	PMID:17537984|RGD:1643596
Biological Process	GO:0021695	cerebellar cortex development	Agtr2	IMP		Rat	PMID:19682991|RGD:6903898
Biological Process	GO:0042416	dopamine biosynthetic process	Agtr2	IMP		Rat	PMID:20097214|RGD:6903884
Biological Process	GO:0035640	exploration behavior	Agtr2	IMP		Mouse	MGI:MGI:76991|PMID:7477267
Biological Process	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	Agtr2	IDA		Mouse	MGI:MGI:4399018|PMID:17000928
Biological Process	GO:0006954	inflammatory response	Agtr2	IGI	MGI:MGI:87965	Mouse	PMID:19404405
Biological Process	GO:0006954	inflammatory response	Agtr2	IGI	MGI:MGI:87964	Mouse	PMID:19404405
Biological Process	GO:0006954	inflammatory response	Agtr2	IDA		Rat	PMID:21209001|RGD:6903279
Biological Process	GO:0035556	intracellular signal transduction	Agtr2	IDA		Mouse	MGI:MGI:4399018|PMID:17000928
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Agtr2	IMP		Rat	PMID:16380540|RGD:1582118
Biological Process	GO:0001822	kidney development	Agtr2	IEP		Rat	PMID:11924718|RGD:6903865
Biological Process	GO:0060993	kidney morphogenesis	Agtr2	IMP		Rat	PMID:18495111|RGD:6903962
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Agtr2	IMP		Rat	PMID:22184331|RGD:6903874
Biological Process	GO:0010459	negative regulation of heart rate	Agtr2	IMP		Mouse	MGI:MGI:3626025|PMID:9449684
Biological Process	GO:0032304	negative regulation of icosanoid secretion	Agtr2	IMP		Rat	PMID:18799632|RGD:2313549
Biological Process	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	AGTR2	IMP		Human	PMID:10406457
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	Agtr2	IDA		Rat	PMID:18670361|RGD:6903961
Biological Process	GO:0051402	neuron apoptotic process	Agtr2	IMP		Mouse	PMID:9310306
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Agtr2	IMP		Mouse	MGI:MGI:3808848|PMID:18607644
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Agtr2	IMP		Rat	PMID:17537984|RGD:1643596
Biological Process	GO:0008284	positive regulation of cell population proliferation	Agtr2	IMP		Rat	PMID:22645419|RGD:6903871
Biological Process	GO:0001819	positive regulation of cytokine production	Agtr2	IMP		Rat	PMID:19033105|RGD:6903960
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Agtr2	IMP		Mouse	MGI:MGI:3808848|PMID:18607644
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Agtr2	IMP		Mouse	MGI:MGI:5009172|PMID:15153556
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	AGTR2	IMP		Human	PMID:10406457
Biological Process	GO:0072300	positive regulation of metanephric glomerulus development	Agtr2	IMP		Mouse	MGI:MGI:3808848|PMID:18607644
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Agtr2	IDA		Mouse	MGI:MGI:4399018|PMID:17000928
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	AGTR2	IDA		Human	PMID:10406457
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Agtr2	IMP		Rat	PMID:16380540|RGD:1582118
Biological Process	GO:0035566	regulation of metanephros size	Agtr2	IMP		Mouse	MGI:MGI:3808848|PMID:18607644
Biological Process	GO:0042306	regulation of protein import into nucleus	Agtr2	IDA		Rat	PMID:14657020|RGD:1566502
Biological Process	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	Agtr2	IMP		Mouse	MGI:MGI:76991|PMID:7477267
Biological Process	GO:0002018	renin-angiotensin regulation of aldosterone production	Agtr2	IMP		Rat	PMID:21318332|RGD:5129178
Biological Process	GO:0010243	response to organonitrogen compound	Agtr2	IEP		Rat	PMID:16025228|RGD:2313553
Biological Process	GO:0042311	vasodilation	AGTR2	IDA		Human	PMID:15117835
Biological Process	GO:0042311	vasodilation	AGTR2	IDA		Human	PMID:17159079
Biological Process	GO:0042311	vasodilation	Agtr2	IMP		Rat	PMID:18463192|RGD:2313550
Biological Process	GO:0042311	vasodilation	Agtr2	IMP		Rat	PMID:23718715|RGD:8549478

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern