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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ahr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ahr
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0017162aryl hydrocarbon receptor bindingAhrIPIUniProtKB:P53762MouseMGI:MGI:5547895|PMID:24001774
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingAHRIDAHumanPMID:23275542
Molecular FunctionGO:0003677DNA bindingAHRIDAHumanPMID:15681594
Molecular FunctionGO:0003677DNA bindingAhrIDAMousePMID:1313028
Molecular FunctionGO:0003700DNA-binding transcription factor activityAHRIDAHumanPMID:11782478
Molecular FunctionGO:0003700DNA-binding transcription factor activityAHRIDAHumanPMID:28602820
Molecular FunctionGO:0003700DNA-binding transcription factor activityAhrIDAMouseMGI:MGI:5904531|PMID:28396409
Molecular FunctionGO:0003700DNA-binding transcription factor activityAhrIDAMousePMID:8215422
Molecular FunctionGO:0003700DNA-binding transcription factor activityAhrIDAMousePMID:1313028
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificAhrIDAMousePMID:18223155
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificahr1bIDAZfishPMID:16042621
Molecular FunctionGO:0070888E-box bindingAhrIDAMouseMGI:MGI:4820700|PMID:20106950
Molecular FunctionGO:0051879Hsp90 protein bindingAHRIDAHumanPMID:9079689
Molecular FunctionGO:0042802identical protein bindingAhrIPIPR:P30561MousePMID:24001774
Molecular FunctionGO:0098531ligand-activated transcription factor activityahr1bIDAZfishPMID:23286227
Molecular FunctionGO:0098531ligand-activated transcription factor activityahr1bIDAZfishPMID:16042621
Molecular FunctionGO:0060090molecular adaptor activityAHREXPHumanPMID:15641800
Molecular FunctionGO:0060090molecular adaptor activityAHRIDAHumanPMID:15641800
Molecular FunctionGO:0004879nuclear receptor activityAHRIDAHumanPMID:34521881
Molecular FunctionGO:0004879nuclear receptor activityAHRIDAHumanPMID:10395741
Molecular FunctionGO:0004879nuclear receptor activityAHRIDAHumanPMID:28602820
Molecular FunctionGO:0004879nuclear receptor activityAHRIDAHumanPMID:32818467
Molecular FunctionGO:0004879nuclear receptor activityAHRIDAHumanPMID:32866000
Molecular FunctionGO:0004879nuclear receptor activityAhrIDAMouseMGI:MGI:49014|PMID:1314586
Molecular FunctionGO:0004879nuclear receptor activityAhrIDAMousePMID:33436590
Molecular FunctionGO:0004879nuclear receptor activityAhrIDARatPMID:7812217|RGD:8553947
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P27540HumanPMID:10395741
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:Q8NI08HumanPMID:10395741
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:Q9Y618HumanPMID:10395741
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P12977HumanPMID:16257957
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P27540HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P53762HumanPMID:28602820
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P27540HumanPMID:34521881
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P27540HumanPMID:9079689
Molecular FunctionGO:0005515protein bindingAHRIPIUniProtKB:P27540HumanPMID:9704006
Molecular FunctionGO:0005515protein bindingAhrIPIUniProtKB:Q9WTL8MouseMGI:MGI:4820700|PMID:20106950
Molecular FunctionGO:0005515protein bindingAhrIPIUniProtKB:P79832MouseMGI:MGI:4418646|PMID:8940073
Molecular FunctionGO:0005515protein bindingAhrIPIUniProtKB:O94763MouseMGI:MGI:5614140|PMID:25453901
Molecular FunctionGO:0005515protein bindingAhrIPIUniProtKB:Q61324MouseMGI:MGI:79449|PMID:8657146
Molecular FunctionGO:0005515protein bindingAhrIPIPR:P53762MousePMID:27782878
Molecular FunctionGO:0005515protein bindingAhrIPIPR:P29595MousePMID:12215427
Molecular FunctionGO:0005515protein bindingAhrIPIPR:P53762MousePMID:28602820
Molecular FunctionGO:0005515protein bindingAhrIPIPR:P53762MousePMID:24001774
Molecular FunctionGO:0005515protein bindingAhrIPIPR:P53762MousePMID:28396409
Molecular FunctionGO:0005515protein bindingAhrIPIUniProtKB:P41739RatPMID:11259609|RGD:8554020
Molecular FunctionGO:0046982protein heterodimerization activityAHRIDAHumanPMID:28602820
Molecular FunctionGO:0046982protein heterodimerization activityAHRIDAHumanPMID:34521881
Molecular FunctionGO:0046982protein heterodimerization activityAhrIDAMouseMGI:MGI:5904531|PMID:28396409
Molecular FunctionGO:0046982protein heterodimerization activityAhrIPIUniProtKB:P79832MouseMGI:MGI:3843443|PMID:11230806
Molecular FunctionGO:0046982protein heterodimerization activityAhrIDAMouseMGI:MGI:5824181|PMID:27782878
Molecular FunctionGO:0046982protein heterodimerization activityAhrIDAMouseMGI:MGI:5547895|PMID:24001774
Molecular FunctionGO:0042803protein homodimerization activityAhrIDAMouseMGI:MGI:5547895|PMID:24001774
Molecular FunctionGO:0051087protein-folding chaperone bindingAhrIPIUniProtKB:P08238MouseMGI:MGI:5810264|PMID:15581363
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-040426-2334ZfishPMID:30321412
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-030124-1ZfishPMID:30321412
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-120320-3ZfishPMID:30321412
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-030723-2ZfishPMID:30321412
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-040630-5ZfishPMID:30321412
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingahr1bIPIZFIN:ZDB-GENE-120319-2ZfishPMID:30321412
Molecular FunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingAHRIPIUniProtKB:O00327HumanPMID:9079689
Molecular FunctionGO:0043565sequence-specific DNA bindingAhrIDAMousePMID:1605850
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingAHRIDAHumanPMID:28602820
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingAHRIDAHumanPMID:34521881
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingAhrIDAMouseMGI:MGI:5904531|PMID:28396409
Molecular FunctionGO:0017025TBP-class protein bindingAHRIPIUniProtKB:P20226HumanPMID:15641800
Molecular FunctionGO:0001094TFIID-class transcription factor complex bindingAHRIPIUniProtKB:O00268HumanPMID:15641800
Molecular FunctionGO:0001094TFIID-class transcription factor complex bindingAHRIPIUniProtKB:P49848HumanPMID:15641800
Molecular FunctionGO:0015643toxic substance bindingAhrIDARatPMID:18938125|RGD:2325669
Molecular FunctionGO:0000976transcription cis-regulatory region bindingAHRIDAHumanPMID:15681594
Molecular FunctionGO:0001223transcription coactivator bindingAHRIPIUniProtKB:Q15596HumanPMID:15641800
Molecular FunctionGO:0001223transcription coactivator bindingAHRIPIUniProtKB:Q15788HumanPMID:15641800
Cellular ComponentGO:0005737cytoplasmAHRIDAHumanPMID:15681594
Cellular ComponentGO:0005737cytoplasmAHRIDAHumanPMID:32818467
Cellular ComponentGO:0005737cytoplasmAhrIDAMouseMGI:MGI:5904531|PMID:28396409
Cellular ComponentGO:0005737cytoplasmAhrIDAMousePMID:12215427
Cellular ComponentGO:0005829cytosolAHRIDAHumanPMID:17329248
Cellular ComponentGO:0005829cytosolAhrIDAMouseMGI:MGI:5284778|PMID:17569696
Cellular ComponentGO:0005829cytosolAhrIDARatPMID:18938125|RGD:2325669
Cellular ComponentGO:0034753nuclear aryl hydrocarbon receptor complexAHRIDAHumanPMID:34521881
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:28602820
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:32866000
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:34521881
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:10395741
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:15681594
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:17329248
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:23275542
Cellular ComponentGO:0005634nucleusAHRIDAHumanPMID:32818467
Cellular ComponentGO:0005634nucleusAhrIDAMouseMGI:MGI:4820700|PMID:20106950
Cellular ComponentGO:0005634nucleusAhrIDAMouseMGI:MGI:5904531|PMID:28396409
Cellular ComponentGO:0005634nucleusAhrIDAMouseMGI:MGI:49014|PMID:1314586
Cellular ComponentGO:0005634nucleusAhrIDAMouseMGI:MGI:5284778|PMID:17569696
Cellular ComponentGO:0005634nucleusAhrIDAMousePMID:33436590
Cellular ComponentGO:0005634nucleusAhrIDARatPMID:18295415|RGD:2325670
Cellular ComponentGO:0005634nucleusAhrIDARatPMID:7812217|RGD:8553947
Cellular ComponentGO:0032991protein-containing complexAHRIMPHumanPMID:15641800
Biological ProcessGO:0001782B cell homeostasisAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0008015blood circulationAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0001568blood vessel developmentAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0097746blood vessel diameter maintenanceAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0048514blood vessel morphogenesisAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0001974blood vessel remodelingAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0001569branching involved in blood vessel morphogenesisAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0043010camera-type eye developmentAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0019933cAMP-mediated signalingAHRIDAHumanPMID:17329248
Biological ProcessGO:0003214cardiac left ventricle morphogenesisAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0000902cell morphogenesisAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0000902cell morphogenesisAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:1904613cellular response to 2,3,7,8-tetrachlorodibenzodioxineAHRIDAHumanPMID:17329248
Biological ProcessGO:1904613cellular response to 2,3,7,8-tetrachlorodibenzodioxineAhrIDAMousePMID:33436590
Biological ProcessGO:1904613cellular response to 2,3,7,8-tetrachlorodibenzodioxineAhrIDARatPMID:9658193|RGD:632171
Biological ProcessGO:1904682cellular response to 3-methylcholanthreneAhrIDAMouseMGI:MGI:49014|PMID:1314586
Biological ProcessGO:0071320cellular response to cAMPAHRIDAHumanPMID:17329248
Biological ProcessGO:1904322cellular response to forskolinAHRIDAHumanPMID:17329248
Biological ProcessGO:0071385cellular response to glucocorticoid stimulusAhrIEPRatPMID:17690134|RGD:2325673
Biological ProcessGO:0071219cellular response to molecule of bacterial originAHRIDAHumanPMID:29454749
Biological ProcessGO:0071407cellular response to organic cyclic compoundahr1aIGIZFIN:ZDB-GENE-011219-1,ZFIN:ZDB-MRPHLNO-050604-1ZfishPMID:16330359
Biological ProcessGO:0032922circadian regulation of gene expressionAhrIDAMouseMGI:MGI:4820700|PMID:20106950
Biological ProcessGO:0003243circumferential growth involved in left ventricle morphogenesisAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0061009common bile duct developmentAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0006351DNA-templated transcriptionahr1bIDAZfishPMID:16042621|ZFIN:ZDB-PUB-050727-18
Biological ProcessGO:0035162embryonic hemopoiesisAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0048732gland developmentAhrIMPMGI:MGI:1857427MousePMID:12151645
Biological ProcessGO:0072102glomerulus morphogenesisAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0002376immune system processAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0060993kidney morphogenesisAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0001889liver developmentAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0001889liver developmentAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0001889liver developmentAhrIMPMouseMGI:MGI:81320|PMID:8692887
Biological ProcessGO:0001889liver developmentAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0002260lymphocyte homeostasisAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0010693negative regulation of alkaline phosphatase activityAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:1903170negative regulation of calcium ion transmembrane transportAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:2000279negative regulation of DNA biosynthetic processAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionAhrIDAMouseMGI:MGI:4820700|PMID:20106950
Biological ProcessGO:0050728negative regulation of inflammatory responseAHRIDAHumanPMID:29454749
Biological ProcessGO:0060547negative regulation of necrotic cell deathAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0045668negative regulation of osteoblast differentiationAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:0033689negative regulation of osteoblast proliferationAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:0003085negative regulation of systemic arterial blood pressureAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0002841negative regulation of T cell mediated immune response to tumor cellAHRIDAHumanPMID:32818467
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIAhrIDAMousePMID:18223155
Biological ProcessGO:0045906negative regulation of vasoconstrictionAhrIMPMouseMGI:MGI:3760685|PMID:14644620
Biological ProcessGO:0001541ovarian follicle developmentAhrIMPRatPMID:20466593|RGD:2325665
Biological ProcessGO:0045793positive regulation of cell sizeAhrIMPMouseMGI:MGI:1889403|PMID:10973493
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionAhrIDAMouseMGI:MGI:4820700|PMID:20106950
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionAhrIDAMousePMID:1313028
Biological ProcessGO:0040010positive regulation of growth rateAhrIMPMouseMGI:MGI:81320|PMID:8692887
Biological ProcessGO:0040010positive regulation of growth rateAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0045899positive regulation of RNA polymerase II transcription preinitiation complex assemblyAhrIDAMousePMID:8215422
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIAHRIDAHumanPMID:32818467
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIAHRIDAHumanPMID:34521881
Biological ProcessGO:0035166post-embryonic hemopoiesisAhrIMPMouseMGI:MGI:81320|PMID:8692887
Biological ProcessGO:0030850prostate gland developmentAhrIMPMGI:MGI:1857427MousePMID:12151645
Biological ProcessGO:0002819regulation of adaptive immune responseAHRIDAHumanPMID:32818467
Biological ProcessGO:0030888regulation of B cell proliferationAHRIDAHumanPMID:15681594
Biological ProcessGO:0006355regulation of DNA-templated transcriptionAHRIDAHumanPMID:10395741
Biological ProcessGO:0006355regulation of DNA-templated transcriptionAhrIDAMouseMGI:MGI:49014|PMID:1314586
Biological ProcessGO:0006355regulation of DNA-templated transcriptionAhrIDARatPMID:7812217|RGD:8553947
Biological ProcessGO:0010468regulation of gene expressionAHRIDAHumanPMID:15681594
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIAHRIDAHumanPMID:15681594
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIAHRIDAHumanPMID:32818467
Biological ProcessGO:0006357regulation of transcription by RNA polymerase IIahr1bIDAZfishPMID:16042621|ZFIN:ZDB-PUB-050727-18
Biological ProcessGO:0048608reproductive structure developmentAhrIMPMGI:MGI:1857427MousePMID:12151645
Biological ProcessGO:0032355response to estradiolAhrIEPRatPMID:20176079|RGD:2325668
Biological ProcessGO:0014070response to organic cyclic compoundAhrIEPRatPMID:18059014|RGD:2325672
Biological ProcessGO:0014070response to organic cyclic compoundAhrIMPRatPMID:20403408|RGD:2325667
Biological ProcessGO:0009636response to toxic substanceAHRIDAHumanPMID:7961644
Biological ProcessGO:0009410response to xenobiotic stimulusAHRIDAHumanPMID:34521881
Biological ProcessGO:0009410response to xenobiotic stimulusAHRIDAHumanPMID:7961644
Biological ProcessGO:0009410response to xenobiotic stimulusAhrIDAMouseMGI:MGI:70018|PMID:7961644
Biological ProcessGO:0009410response to xenobiotic stimulusAhrIDARatPMID:12193573|RGD:625678
Biological ProcessGO:0009410response to xenobiotic stimulusAhrIDARatPMID:9658193|RGD:632171
Biological ProcessGO:0048745smooth muscle tissue developmentAhrIMPMouseMGI:MGI:3794480|PMID:16443691
Biological ProcessGO:0048536spleen developmentAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0048536spleen developmentAhrIMPMouseMGI:MGI:81320|PMID:8692887
Biological ProcessGO:0043029T cell homeostasisAhrIMPMouseMGI:MGI:72762|PMID:7732381
Biological ProcessGO:0006366transcription by RNA polymerase IIAhrIDAMouseMGI:MGI:49014|PMID:1314586
Biological ProcessGO:0006366transcription by RNA polymerase IIAhrIDARatPMID:7812217|RGD:8553947
Biological ProcessGO:0060841venous blood vessel developmentAhrIMPMouseMGI:MGI:3794480|PMID:16443691

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory