Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AIF1
  • Mouse genes Aif1
  • Rat genes Aif1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aif1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	AIF1	IDA		Human	PMID:16049345
Molecular Function	GO:0051015	actin filament binding	AIF1	IDA		Human	PMID:18699778
Molecular Function	GO:0051015	actin filament binding	Aif1	IMP		Mouse	MGI:MGI:6275442|PMID:11500035
Molecular Function	GO:0005509	calcium ion binding	Aif1	IDA		Mouse	MGI:MGI:5315342|PMID:17011575
Molecular Function	GO:0005515	protein binding	AIF1	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AIF1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Aif1	IPI	UniProtKB:P13797	Mouse	PMID:14756805
Molecular Function	GO:0005515	protein binding	Aif1	IPI	PR:Q61233	Mouse	PMID:14756805
Molecular Function	GO:0005515	protein binding	Aif1	IPI	UniProtKB:P13796	Mouse	PMID:14756805
Cellular Component	GO:0005884	actin filament	AIF1	IDA		Human	PMID:18699778
Cellular Component	GO:0005884	actin filament	Aif1	IDA		Mouse	PMID:14756805
Cellular Component	GO:0042995	cell projection	Aif1	IDA		Rat	PMID:19249294|RGD:2313011
Cellular Component	GO:0005737	cytoplasm	AIF1	IDA		Human	PMID:12887599
Cellular Component	GO:0005737	cytoplasm	AIF1	IDA		Human	PMID:28601280
Cellular Component	GO:0005737	cytoplasm	Aif1	IDA		Mouse	MGI:MGI:5315376|PMID:10934045
Cellular Component	GO:0005737	cytoplasm	Aif1	IDA		Mouse	PMID:14756805
Cellular Component	GO:0005737	cytoplasm	Aif1	IDA		Rat	PMID:7769138|RGD:61535
Cellular Component	GO:0005829	cytosol	AIF1	IDA		Human	PMID:22116621
Cellular Component	GO:0005829	cytosol	Aif1	IDA		Rat	PMID:18722361|RGD:2313014
Cellular Component	GO:0097386	glial cell projection	Aif1	IDA		Mouse	PMID:14756805
Cellular Component	GO:0030027	lamellipodium	Aif1	IDA		Mouse	MGI:MGI:5315376|PMID:10934045
Cellular Component	GO:0030027	lamellipodium	Aif1	IDA		Rat	PMID:16877440|RGD:2313019
Cellular Component	GO:0005634	nucleus	AIF1	IDA		Human	PMID:22116621
Cellular Component	GO:0005634	nucleus	Aif1	IDA		Mouse	MGI:MGI:5315376|PMID:10934045
Cellular Component	GO:0043204	perikaryon	Aif1	IDA		Rat	PMID:19249294|RGD:2313011
Cellular Component	GO:0048471	perinuclear region of cytoplasm	AIF1	IDA		Human	PMID:9614071
Cellular Component	GO:0001891	phagocytic cup	Aif1	IDA		Mouse	MGI:MGI:5315376|PMID:10934045
Cellular Component	GO:0001891	phagocytic cup	Aif1	IDA		Mouse	PMID:14756805
Cellular Component	GO:0001726	ruffle	Aif1	IDA		Mouse	PMID:14756805
Cellular Component	GO:0032587	ruffle membrane	AIF1	IDA		Human	PMID:18699778
Cellular Component	GO:0032587	ruffle membrane	Aif1	IDA		Mouse	MGI:MGI:5315376|PMID:10934045
Biological Process	GO:0051764	actin crosslink formation	Aif1	IMP		Mouse	MGI:MGI:6275442|PMID:11500035
Biological Process	GO:0051017	actin filament bundle assembly	AIF1	IDA		Human	PMID:18699778
Biological Process	GO:0051017	actin filament bundle assembly	Aif1	IDA		Mouse	PMID:14756805
Biological Process	GO:0030041	actin filament polymerization	AIF1	IDA		Human	PMID:16049345
Biological Process	GO:0031668	cellular response to extracellular stimulus	Aif1	IEP		Rat	PMID:18717813|RGD:2313015
Biological Process	GO:0032870	cellular response to hormone stimulus	Aif1	IEP		Rat	PMID:7769138|RGD:61535
Biological Process	GO:0071447	cellular response to hydroperoxide	Aif1	IEP		Rat	PMID:16877440|RGD:2313019
Biological Process	GO:0071315	cellular response to morphine	Aif1	IEP		Rat	PMID:19176808|RGD:2313012
Biological Process	GO:0034599	cellular response to oxidative stress	AIF1	IDA		Human	PMID:12887599
Biological Process	GO:0071346	cellular response to type II interferon	AIF1	IEP		Human	PMID:9614071
Biological Process	GO:0071346	cellular response to type II interferon	Aif1	IEP		Rat	PMID:7769138|RGD:61535
Biological Process	GO:0021549	cerebellum development	Aif1	IEP		Rat	PMID:9698327|RGD:704401
Biological Process	GO:0006954	inflammatory response	Aif1	IEP		Rat	PMID:7769138|RGD:61535
Biological Process	GO:0043066	negative regulation of apoptotic process	Aif1	IDA		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0043066	negative regulation of apoptotic process	Aif1	IMP		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0010629	negative regulation of gene expression	Aif1	IMP		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0071672	negative regulation of smooth muscle cell chemotaxis	AIF1	IDA		Human	PMID:22116621
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	AIF1	IDA		Human	PMID:22116621
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	AIF1	IDA		Human	PMID:9614071
Biological Process	GO:0030046	parallel actin filament bundle assembly	Aif1	IDA		Mouse	MGI:MGI:6275442|PMID:11500035
Biological Process	GO:0006911	phagocytosis, engulfment	Aif1	IMP		Mouse	MGI:MGI:5315376|PMID:10934045
Biological Process	GO:0030335	positive regulation of cell migration	AIF1	IDA		Human	PMID:19745784
Biological Process	GO:0030335	positive regulation of cell migration	Aif1	IDA		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0030335	positive regulation of cell migration	Aif1	IMP		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0008284	positive regulation of cell population proliferation	AIF1	IDA		Human	PMID:19745784
Biological Process	GO:0032722	positive regulation of chemokine production	AIF1	IDA		Human	PMID:24796669
Biological Process	GO:0050921	positive regulation of chemotaxis	AIF1	IDA		Human	PMID:24796669
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	AIF1	IDA		Human	PMID:19745784
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	AIF1	IDA		Human	PMID:11557666
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	AIF1	IDA		Human	PMID:15117732
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	AIF1	IDA		Human	PMID:19745784
Biological Process	GO:0032755	positive regulation of interleukin-6 production	AIF1	IDA		Human	PMID:24796669
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	AIF1	IDA		Human	PMID:15117732
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	AIF1	IDA		Human	PMID:24796669
Biological Process	GO:0014739	positive regulation of muscle hyperplasia	Aif1	IMP		Rat	PMID:18779232|RGD:2313013
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Aif1	IDA		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Aif1	IMP		Rat	PMID:16157606|RGD:2313017
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Aif1	IMP		Rat	PMID:18779232|RGD:2313013
Biological Process	GO:0071673	positive regulation of smooth muscle cell chemotaxis	AIF1	IDA		Human	PMID:22116621
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	AIF1	IDA		Human	PMID:15117732
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	AIF1	IDA		Human	PMID:22116621
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Aif1	IMP		Rat	PMID:18779232|RGD:2313013
Biological Process	GO:2000406	positive regulation of T cell migration	AIF1	IDA		Human	PMID:16049345
Biological Process	GO:0042102	positive regulation of T cell proliferation	AIF1	IDA		Human	PMID:16049345
Biological Process	GO:0016601	Rac protein signal transduction	Aif1	IMP		Mouse	MGI:MGI:5315376|PMID:10934045
Biological Process	GO:0010468	regulation of gene expression	AIF1	HDA		Human	PMID:24796669
Biological Process	GO:0048678	response to axon injury	Aif1	IEP		Rat	PMID:19331524|RGD:2313010
Biological Process	GO:0034097	response to cytokine	Aif1	IEP		Rat	PMID:17394154|RGD:2313016
Biological Process	GO:0051602	response to electrical stimulus	Aif1	IEP		Rat	PMID:19410369|RGD:2306919
Biological Process	GO:0051384	response to glucocorticoid	Aif1	IEP		Rat	PMID:17265048|RGD:8693610
Biological Process	GO:0097178	ruffle assembly	Aif1	IMP		Mouse	MGI:MGI:5315376|PMID:10934045

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern