Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aifm1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AIFM1
- Mouse genes Aifm1
- Rat genes Aifm1
- Zfish genes aifm1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aifm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	AIFM1	IDA		Human	PMID:27178839
Molecular Function	GO:0003677	DNA binding	Aifm1	IDA		Mouse	MGI:MGI:5430718\|PMID:21467298
Molecular Function	GO:0071949	FAD binding	AIFM1	IDA		Human	PMID:27178839
Molecular Function	GO:0071949	FAD binding	Aifm1	IDA		Mouse	MGI:MGI:5430718\|PMID:21467298
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	AIFM1	IDA		Human	PMID:27178839
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	Aifm1	IDA		Mouse	MGI:MGI:5430718\|PMID:21467298
Molecular Function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	AIFM1	IDA		Human	PMID:23217327
Molecular Function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	AIFM1	IDA		Human	PMID:27178839
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	Aifm1	IDA		Mouse	MGI:MGI:5430718\|PMID:21467298
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q9Y3Q8	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:O75821	Human	PMID:17094969
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q9Y255	Human	PMID:21364629
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q5EP34	Human	PMID:21715506
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q63ZY3	Human	PMID:22371500
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q63ZY3-2	Human	PMID:22371500
Molecular Function	GO:0005515	protein binding	AIFM1	IPI	UniProtKB:Q8N4Q1	Human	PMID:26004228
Molecular Function	GO:0005515	protein binding	Aifm1	IPI	UniProtKB:Q9EQN3	Mouse	MGI:MGI:5513085\|PMID:23305244
Molecular Function	GO:0005515	protein binding	Aifm1	IPI	UniProtKB:Q9Z1R2	Mouse	MGI:MGI:3774040\|PMID:18056262
Molecular Function	GO:0005515	protein binding	Aifm1	IPI	UniProtKB:P16104	Mouse	MGI:MGI:4442265\|PMID:20360685
Molecular Function	GO:0005515	protein binding	Aifm1	IPI	UniProtKB:P27661	Mouse	MGI:MGI:4442265\|PMID:20360685
Cellular Component	GO:0005737	cytoplasm	Aifm1	IDA		Mouse	PMID:14707049
Cellular Component	GO:0005737	cytoplasm	Aifm1	IDA		Rat	PMID:12871572\|RGD:10053564
Cellular Component	GO:0005829	cytosol	Aifm1	IDA		Mouse	MGI:MGI:3774040\|PMID:18056262
Cellular Component	GO:0005829	cytosol	Aifm1	IDA		Mouse	PMID:19139267
Cellular Component	GO:0005829	cytosol	Aifm1	IDA		Rat	PMID:15181376\|RGD:10047403
Cellular Component	GO:0005829	cytosol	Aifm1	IDA		Rat	PMID:16776830\|RGD:10053566
Cellular Component	GO:0005758	mitochondrial intermembrane space	AIFM1	IDA		Human	PMID:15775970
Cellular Component	GO:0005758	mitochondrial intermembrane space	AIFM1	IDA		Human	PMID:26004228
Cellular Component	GO:0005739	mitochondrion	AIFM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	AIFM1	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	MGI:MGI:3774040\|PMID:18056262
Cellular Component	GO:0005739	mitochondrion	Aifm1	IMP		Mouse	MGI:MGI:5430718\|PMID:21467298
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	MGI:MGI:4442265\|PMID:20360685
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	MGI:MGI:6445044\|PMID:30830864
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	PMID:21502359
Cellular Component	GO:0005739	mitochondrion	Aifm1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	PMID:15271982
Cellular Component	GO:0005739	mitochondrion	Aifm1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	PMID:19139267
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Mouse	PMID:16469926
Cellular Component	GO:0005739	mitochondrion	Aifm1	IDA		Rat	PMID:12453066\|RGD:633556
Cellular Component	GO:0005634	nucleus	AIFM1	IDA		Human	PMID:23217327
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	MGI:MGI:4442265\|PMID:20360685
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	MGI:MGI:3774040\|PMID:18056262
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	MGI:MGI:2182480\|PMID:12114629
Cellular Component	GO:0005634	nucleus	Aifm1	IMP		Mouse	MGI:MGI:5430718\|PMID:21467298
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	PMID:24191052
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	PMID:16469926
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Mouse	PMID:14707049
Cellular Component	GO:0005634	nucleus	Aifm1	IDA		Rat	PMID:12453066\|RGD:633556
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	AIFM1	IDA		Human	PMID:17094969
Biological Process	GO:0006915	apoptotic process	AIFM1	IMP		Human	PMID:23217327
Biological Process	GO:1904045	cellular response to aldosterone	Aifm1	IEP		Rat	PMID:24551180\|RGD:10047410
Biological Process	GO:0071392	cellular response to estradiol stimulus	Aifm1	IEP		Rat	PMID:16776830\|RGD:10053566
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Aifm1	IEP		Rat	PMID:11781347\|RGD:10047407
Biological Process	GO:0071732	cellular response to nitric oxide	Aifm1	IEP		Rat	PMID:18560609\|RGD:10053561
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Aifm1	IEP		Rat	PMID:14526224\|RGD:10047409
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Aifm1	IMP		Mouse	MGI:MGI:3774040\|PMID:18056262
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	AIFM1	IMP		Human	PMID:26004228
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	Aifm1	IMP		Mouse	MGI:MGI:6114310\|PMID:26004228
Biological Process	GO:0051402	neuron apoptotic process	Aifm1	IGI	MGI:MGI:1306796	Mouse	PMID:15703386
Biological Process	GO:0060545	positive regulation of necroptotic process	Aifm1	IDA		Mouse	MGI:MGI:2182480\|PMID:12114629
Biological Process	GO:0060545	positive regulation of necroptotic process	Aifm1	IDA		Mouse	MGI:MGI:5430718\|PMID:21467298
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Aifm1	IMP		Rat	PMID:20177052\|RGD:10047406
Biological Process	GO:0045041	protein import into mitochondrial intermembrane space	AIFM1	IMP		Human	PMID:26004228
Biological Process	GO:0045041	protein import into mitochondrial intermembrane space	Aifm1	IMP		Mouse	MGI:MGI:6114310\|PMID:26004228
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	Aifm1	IGI	MGI:MGI:1306796	Mouse	PMID:15703386
Biological Process	GO:0002931	response to ischemia	Aifm1	IEP		Rat	PMID:15181376\|RGD:10047403
Biological Process	GO:1902065	response to L-glutamate	Aifm1	IEP		Rat	PMID:16776830\|RGD:10053566
Biological Process	GO:0009636	response to toxic substance	Aifm1	IEP		Rat	PMID:11781347\|RGD:10047407

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.