Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AIFM2
  • Mouse genes Aifm2
  • Rat genes Aifm2
  • Zfish genes aifm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aifm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	AIFM2	IDA		Human	PMID:15958387
Molecular Function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	AIFM2	IDA		Human	PMID:15958387
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	AIFM2	IDA		Human	PMID:15958387
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AIFM2	IDA		Human	PMID:31634899
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AIFM2	IDA		Human	PMID:31634900
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AIFM2	IDA		Human	PMID:35922516
Molecular Function	GO:0005515	protein binding	AIFM2	IPI	UniProtKB:Q86WT6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AIFM2	IPI	UniProtKB:Q8N129	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AIFM2	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Aifm2	IPI	UniProtKB:P52293|UniProtKB:Q8BKC5	Mouse	MGI:MGI:6378077|PMID:26689472
Cellular Component	GO:0005737	cytoplasm	AIFM2	IDA		Human	PMID:12135761
Cellular Component	GO:0005737	cytoplasm	Aifm2	IDA		Mouse	MGI:MGI:6378077|PMID:26689472
Cellular Component	GO:0005829	cytosol	AIFM2	IDA		Human	PMID:11980907
Cellular Component	GO:0005615	extracellular space	AIFM2	HDA		Human	PMID:22664934
Cellular Component	GO:0005811	lipid droplet	AIFM2	IDA		Human	PMID:14741744
Cellular Component	GO:0005811	lipid droplet	AIFM2	IDA		Human	PMID:31634900
Cellular Component	GO:0031966	mitochondrial membrane	Aifm2	IDA		Mouse	MGI:MGI:6378077|PMID:26689472
Cellular Component	GO:0005741	mitochondrial outer membrane	AIFM2	IDA		Human	PMID:11980907
Cellular Component	GO:0005739	mitochondrion	AIFM2	IDA		Human	PMID:11980907
Cellular Component	GO:0005739	mitochondrion	Aifm2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	Aifm2	IDA		Mouse	MGI:MGI:6378077|PMID:26689472
Cellular Component	GO:0005886	plasma membrane	AIFM2	IDA		Human	PMID:31634900
Biological Process	GO:0008637	apoptotic mitochondrial changes	AIFM2	IDA		Human	PMID:11980907
Biological Process	GO:1990748	cellular detoxification	AIFM2	IDA		Human	PMID:35922516
Biological Process	GO:0110076	negative regulation of ferroptosis	AIFM2	IMP		Human	PMID:31634899
Biological Process	GO:0110076	negative regulation of ferroptosis	AIFM2	IMP		Human	PMID:31634900
Biological Process	GO:0110076	negative regulation of ferroptosis	AIFM2	IDA		Human	PMID:35922516
Biological Process	GO:0043065	positive regulation of apoptotic process	AIFM2	IDA		Human	PMID:11980907
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	Aifm2	IMP		Mouse	MGI:MGI:6378077|PMID:26689472
Biological Process	GO:0006743	ubiquinone metabolic process	AIFM2	IDA		Human	PMID:31634899
Biological Process	GO:0006743	ubiquinone metabolic process	AIFM2	IDA		Human	PMID:31634900
Biological Process	GO:0042373	vitamin K metabolic process	AIFM2	IDA		Human	PMID:35922516

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern