Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Aim2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AIM2
- Mouse genes Aim2
- Rat genes Aim2
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aim2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	AIM2	IDA		Human	PMID:19158679
Molecular Function	GO:0003690	double-stranded DNA binding	AIM2	IDA		Human	PMID:19158675
Molecular Function	GO:0003690	double-stranded DNA binding	AIM2	IDA		Human	PMID:26197926
Molecular Function	GO:0003690	double-stranded DNA binding	AIM2	IDA		Human	PMID:26583071
Molecular Function	GO:0003690	double-stranded DNA binding	AIM2	IDA		Human	PMID:29440442
Molecular Function	GO:0003690	double-stranded DNA binding	AIM2	IDA		Human	PMID:33980849
Molecular Function	GO:0003690	double-stranded DNA binding	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Molecular Function	GO:0003690	double-stranded DNA binding	Aim2	IDA		Mouse	PMID:19158679
Molecular Function	GO:0003690	double-stranded DNA binding	Aim2	IDA		Mouse	PMID:23567559
Molecular Function	GO:0003690	double-stranded DNA binding	Aim2	IDA		Mouse	PMID:27846608
Molecular Function	GO:0003690	double-stranded DNA binding	Aim2	IDA		Mouse	PMID:32350463
Molecular Function	GO:0042802	identical protein binding	AIM2	IPI	UniProtKB:O14862	Human	PMID:19158676
Molecular Function	GO:0042802	identical protein binding	AIM2	IPI	UniProtKB:O14862	Human	PMID:24630722
Molecular Function	GO:0042802	identical protein binding	Aim2	IPI	UniProtKB:Q91VJ1	Mouse	MGI:MGI:3839523\|PMID:19158676
Molecular Function	GO:0140677	molecular function activator activity	Aim2	IDA		Mouse	PMID:27846608
Molecular Function	GO:0140677	molecular function activator activity	Aim2	IDA		Mouse	PMID:32350463
Molecular Function	GO:0140677	molecular function activator activity	Aim2	IDA		Mouse	PMID:23567559
Molecular Function	GO:0038187	pattern recognition receptor activity	AIM2	IDA		Human	PMID:26197926
Molecular Function	GO:0038187	pattern recognition receptor activity	Aim2	IDA		Mouse	PMID:23567559
Molecular Function	GO:0038187	pattern recognition receptor activity	Aim2	IDA		Mouse	PMID:27846608
Molecular Function	GO:0038187	pattern recognition receptor activity	Aim2	IDA		Mouse	PMID:32350463
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:19158675
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:19158676
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:22286270
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:P19525	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:24237704
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:24531343
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:W6CW81	Human	PMID:24531343
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q9ULZ3	Human	PMID:24630722
Molecular Function	GO:0005515	protein binding	AIM2	IPI	UniProtKB:Q16666-8	Human	PMID:30104205
Molecular Function	GO:0005515	protein binding	Aim2	IPI	UniProtKB:Q9R002	Mouse	MGI:MGI:6832446\|PMID:23850291
Molecular Function	GO:0005515	protein binding	Aim2	IPI	PR:Q9EPB4	Mouse	PMID:19158679
Molecular Function	GO:0035591	signaling adaptor activity	AIM2	IDA		Human	PMID:23530044
Molecular Function	GO:0035591	signaling adaptor activity	AIM2	IDA		Human	PMID:26197926
Molecular Function	GO:0035591	signaling adaptor activity	AIM2	IDA		Human	PMID:29440442
Molecular Function	GO:0035591	signaling adaptor activity	AIM2	IDA		Human	PMID:33980849
Molecular Function	GO:0035591	signaling adaptor activity	Aim2	IDA	UniProtKB:O14862	Mouse	PMID:26197926
Molecular Function	GO:0030546	signaling receptor activator activity	Aim2	IDA		Mouse	PMID:27846608
Molecular Function	GO:0030546	signaling receptor activator activity	Aim2	IDA		Mouse	PMID:32350463
Molecular Function	GO:0030546	signaling receptor activator activity	Aim2	IDA		Mouse	PMID:23567559
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IPI		Human	PMID:24630722
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IDA		Human	PMID:19158676
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IDA		Human	PMID:19158679
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IDA		Human	PMID:26197926
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IDA		Human	PMID:29440442
Cellular Component	GO:0097169	AIM2 inflammasome complex	AIM2	IDA		Human	PMID:33980849
Cellular Component	GO:0097169	AIM2 inflammasome complex	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Cellular Component	GO:0097169	AIM2 inflammasome complex	Aim2	IDA		Mouse	PMID:19158679
Cellular Component	GO:0005737	cytoplasm	AIM2	IDA		Human	PMID:8454910
Cellular Component	GO:0005737	cytoplasm	AIM2	IDA		Human	PMID:19158676
Cellular Component	GO:0005737	cytoplasm	AIM2	IDA		Human	PMID:24531343
Cellular Component	GO:0005737	cytoplasm	Aim2	IDA		Mouse	PMID:19158679
Cellular Component	GO:0005737	cytoplasm	Aim2	IDA		Mouse	PMID:23567559
Cellular Component	GO:0005829	cytosol	AIM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	AIM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	AIM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Cellular Component	GO:0035861	site of double-strand break	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Cellular Component	GO:0035861	site of double-strand break	Aim2	IDA		Mouse	PMID:27846608
Biological Process	GO:0002218	activation of innate immune response	AIM2	IDA		Human	PMID:19158675
Biological Process	GO:0002218	activation of innate immune response	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:0002218	activation of innate immune response	AIM2	IDA		Human	PMID:19158679
Biological Process	GO:0002218	activation of innate immune response	Aim2	IDA		Mouse	MGI:MGI:3839523\|PMID:19158676
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:19158679
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:23530044
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:26197926
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:26583071
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:29440442
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	AIM2	IDA		Human	PMID:33980849
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	MGI:MGI:6713897\|PMID:34006824
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	MGI:MGI:6101070\|PMID:29033131
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	PMID:27693356
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	PMID:23567559
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	PMID:27846608
Biological Process	GO:0140970	AIM2 inflammasome complex assembly	Aim2	IDA		Mouse	PMID:32350463
Biological Process	GO:0007420	brain development	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:0007420	brain development	Aim2	IDA		Mouse	PMID:32350463
Biological Process	GO:0035458	cellular response to interferon-beta	Aim2	IDA		Mouse	PMID:19158679
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	AIM2	IDA		Human	PMID:19158679
Biological Process	GO:0006974	DNA damage response	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:0006974	DNA damage response	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Biological Process	GO:0006974	DNA damage response	Aim2	IDA		Mouse	PMID:27846608
Biological Process	GO:0006974	DNA damage response	Aim2	IDA		Mouse	PMID:32350463
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	AIM2	IDA		Human	PMID:16432157
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Aim2	IDA		Mouse	MGI:MGI:5688241\|PMID:26095253
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Aim2	IDA		Mouse	MGI:MGI:5708447\|PMID:26107252
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Aim2	IDA		Mouse	MGI:MGI:6710169\|PMID:33505023
Biological Process	GO:0070050	neuron cellular homeostasis	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	AIM2	IDA		Human	PMID:19158679
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	Aim2	IMP		Mouse	MGI:MGI:5437433\|PMID:19131592
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	Aim2	IDA		Mouse	MGI:MGI:3839523\|PMID:19158676
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Aim2	IMP		Mouse	MGI:MGI:3839029\|PMID:19158675
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	AIM2	IDA		Human	PMID:19158675
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	AIM2	IDA		Human	PMID:19158679
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	AIM2	IDA		Human	PMID:24630722
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Aim2	IDA		Mouse	MGI:MGI:3839523\|PMID:19158676
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Aim2	IMP		Mouse	MGI:MGI:3839029\|PMID:19158675
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Aim2	IDA		Mouse	MGI:MGI:6713897\|PMID:34006824
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Aim2	IGI	MGI:MGI:2653833	Mouse	PMID:23997220
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	AIM2	IDA		Human	PMID:19158675
Biological Process	GO:0070269	pyroptosis	AIM2	IDA		Human	PMID:19158675
Biological Process	GO:0070269	pyroptosis	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:0070269	pyroptosis	Aim2	IDA		Mouse	MGI:MGI:5807418\|PMID:27846608
Biological Process	GO:0070269	pyroptosis	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:0070269	pyroptosis	Aim2	IDA		Mouse	MGI:MGI:3839523\|PMID:19158676
Biological Process	GO:0070269	pyroptosis	Aim2	IDA		Mouse	MGI:MGI:6713897\|PMID:34006824
Biological Process	GO:0070269	pyroptosis	Aim2	IDA		Mouse	MGI:MGI:6101070\|PMID:29033131
Biological Process	GO:1904270	pyroptosome complex assembly	AIM2	IDA		Human	PMID:19158676
Biological Process	GO:0050795	regulation of behavior	Aim2	IDA		Mouse	MGI:MGI:6445914\|PMID:32350463
Biological Process	GO:0043029	T cell homeostasis	Aim2	IDA		Mouse	MGI:MGI:6710169\|PMID:33505023
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	AIM2	IDA		Human	PMID:16432157

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/24/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.