Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AJUBA
  • Mouse genes Ajuba
  • Rat genes Ajuba
  • Zfish genes ajuba
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ajuba

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Ajuba	IDA		Mouse	PMID:12417594
Molecular Function	GO:0045294	alpha-catenin binding	AJUBA	IDA		Human	PMID:12417594
Molecular Function	GO:0045294	alpha-catenin binding	Ajuba	IDA		Mouse	PMID:12417594
Molecular Function	GO:0003682	chromatin binding	Ajuba	IDA		Mouse	PMID:18347060
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:P31947	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9NRM7	Human	PMID:16413547
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:O95863	Human	PMID:18331720
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q99684	Human	PMID:18805794
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:O95835	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9H4B6	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9NRM7	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:P06730	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:P26196	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q8IU60	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9UKV8	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9UL18	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:P40337	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q96KS0	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9H6Z9	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:O95863	Human	PMID:25314079
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:O95363	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q01664	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q02930-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q8NEC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q8TCE9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q96KM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q99816	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9BXF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q9H0D2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AJUBA	IPI	UniProtKB:Q99816	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Ajuba	IPI	UniProtKB:Q99684	Mouse	MGI:MGI:3773767|PMID:17909014
Molecular Function	GO:0005515	protein binding	Ajuba	IPI	UniProtKB:P19382|UniProtKB:P97469|UniProtKB:Q02085|UniProtKB:Q99M85	Mouse	MGI:MGI:5318024|PMID:18331720
Molecular Function	GO:0005515	protein binding	Ajuba	IPI	UniProtKB:O14744|UniProtKB:P10276|UniProtKB:P18911|UniProtKB:P48443	Mouse	MGI:MGI:5919154|PMID:20133701
Molecular Function	GO:0005515	protein binding	Ajuba	IPI	PR:P70182	Mouse	PMID:15870270
Molecular Function	GO:0005515	protein binding	Ajuba	IPI	PR:Q60631	Mouse	PMID:10330178
Molecular Function	GO:0003714	transcription corepressor activity	AJUBA	IDA		Human	PMID:18805794
Molecular Function	GO:0003714	transcription corepressor activity	Ajuba	IDA		Mouse	MGI:MGI:3773767|PMID:17909014
Molecular Function	GO:0003714	transcription corepressor activity	Ajuba	IMP		Mouse	MGI:MGI:5318024|PMID:18331720
Cellular Component	GO:0005911	cell-cell junction	AJUBA	IDA		Human	PMID:12417594
Cellular Component	GO:0005911	cell-cell junction	Ajuba	IDA		Rat	PMID:12417594|RGD:8554656
Cellular Component	GO:0005829	cytosol	AJUBA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ajuba	IDA		Mouse	PMID:10330178
Cellular Component	GO:0005925	focal adhesion	Ajuba	IDA		Mouse	PMID:15728191
Cellular Component	GO:0005794	Golgi apparatus	AJUBA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	Ajuba	IDA		Mouse	PMID:15728191
Cellular Component	GO:0005654	nucleoplasm	AJUBA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	AJUBA	IDA		Human	PMID:18805794
Cellular Component	GO:0005634	nucleus	Ajuba	IDA		Mouse	MGI:MGI:5318024|PMID:18331720
Cellular Component	GO:0005634	nucleus	Ajuba	IDA		Mouse	PMID:18347060
Cellular Component	GO:0005634	nucleus	Ajuba	IDA		Mouse	PMID:19376971
Cellular Component	GO:0000932	P-body	AJUBA	IDA		Human	PMID:20616046
Cellular Component	GO:0005667	transcription regulator complex	Ajuba	IDA		Mouse	PMID:18347060
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:12417594
Biological Process	GO:0048041	focal adhesion assembly	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:15728191
Biological Process	GO:0046474	glycerophospholipid biosynthetic process	Ajuba	IMP		Mouse	PMID:15870270
Biological Process	GO:0007507	heart development	ajuba	IMP	ZFIN:ZDB-MRPHLNO-120821-6	Zfish	PMID:22771034
Biological Process	GO:0007507	heart development	ajuba	IMP	ZFIN:ZDB-MRPHLNO-120821-5	Zfish	PMID:22771034
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ajuba	IMP		Mouse	PMID:15870274
Biological Process	GO:0030032	lamellipodium assembly	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:15728191
Biological Process	GO:0035195	miRNA-mediated gene silencing	AJUBA	IMP		Human	PMID:20616046
Biological Process	GO:0035331	negative regulation of hippo signaling	AJUBA	IDA		Human	PMID:20303269
Biological Process	GO:0033673	negative regulation of kinase activity	Ajuba	IDA		Mouse	PMID:15870270
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ajuba	IMP		Mouse	PMID:18347060
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process	Ajuba	IMP		Mouse	PMID:15870270
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ajuba	IMP		Mouse	PMID:15870274
Biological Process	GO:0033674	positive regulation of kinase activity	Ajuba	IDA		Mouse	PMID:15870270
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Ajuba	IDA		Mouse	PMID:10330178
Biological Process	GO:2000637	positive regulation of miRNA-mediated gene silencing	AJUBA	IMP		Human	PMID:20616046
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	AJUBA	IDA		Human	PMID:15870274
Biological Process	GO:0008104	protein localization	Ajuba	IMP		Mouse	PMID:15870270
Biological Process	GO:0030334	regulation of cell migration	Ajuba	IDA		Mouse	PMID:15728191
Biological Process	GO:0030334	regulation of cell migration	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:15728191
Biological Process	GO:1900037	regulation of cellular response to hypoxia	AJUBA	IDA		Human	PMID:22286099
Biological Process	GO:0043087	regulation of GTPase activity	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:15728191
Biological Process	GO:0001666	response to hypoxia	AJUBA	IDA		Human	PMID:22286099
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	Ajuba	IMP	MGI:MGI:3578221	Mouse	PMID:15728191

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern