Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AK2
  • Mouse genes Ak2
  • Rat genes Ak2
  • Zfish genes ak2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ak2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004017	adenylate kinase activity	AK2	EXP		Human	PMID:6182143
Molecular Function	GO:0004017	adenylate kinase activity	Ak2	IDA		Rat	PMID:19049516|RGD:5134369
Molecular Function	GO:0019205	nucleobase-containing compound kinase activity	Ak2	IDA		Rat	PMID:19049516|RGD:5134369
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P08670	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P49810	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AK2	IPI	UniProtKB:P54253	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	Ak2	IDA		Rat	PMID:22246993|RGD:11100024
Cellular Component	GO:0005829	cytosol	Ak2	IDA		Rat	PMID:9504419|RGD:2301092
Cellular Component	GO:0070062	extracellular exosome	AK2	HDA		Human	PMID:20458337
Cellular Component	GO:0005743	mitochondrial inner membrane	Ak2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005758	mitochondrial intermembrane space	Ak2	IDA		Rat	PMID:19139979|RGD:5134368
Cellular Component	GO:0005739	mitochondrion	Ak2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Ak2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Ak2	IDA		Rat	PMID:9504419|RGD:2301092
Cellular Component	GO:0005634	nucleus	Ak2	IDA		Rat	PMID:22246993|RGD:11100024
Cellular Component	GO:0036126	sperm flagellum	Ak2	IDA		Mouse	PMID:16790685
Cellular Component	GO:0097226	sperm mitochondrial sheath	Ak2	IDA		Mouse	PMID:16790685
Biological Process	GO:0006172	ADP biosynthetic process	Ak2	IDA		Rat	PMID:5123889|RGD:5490208
Biological Process	GO:0046033	AMP metabolic process	Ak2	IDA		Rat	PMID:5010295|RGD:5490216
Biological Process	GO:0046034	ATP metabolic process	Ak2	IDA		Rat	PMID:5010295|RGD:5490216
Biological Process	GO:0007420	brain development	Ak2	IEP		Rat	PMID:9920788|RGD:632499
Biological Process	GO:0046060	dATP metabolic process	Ak2	IDA		Rat	PMID:5010295|RGD:5490216
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ak2	IMP	ZFIN:ZDB-MRPHLNO-090108-2,ZFIN:ZDB-MRPHLNO-151117-1	Zfish	PMID:26150473
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ak2	IMP	ZFIN:ZDB-GENO-151210-8	Zfish	PMID:26150473
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ak2	IMP	ZFIN:ZDB-MRPHLNO-151117-1	Zfish	PMID:26150473
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ak2	IMP	ZFIN:ZDB-GENO-151210-6	Zfish	PMID:26150473
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ak2	IMP	ZFIN:ZDB-MRPHLNO-090108-2,ZFIN:ZDB-MRPHLNO-151117-1	Zfish	PMID:26150473
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ak2	IMP	ZFIN:ZDB-MRPHLNO-151117-1	Zfish	PMID:26150473
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ak2	IMP	ZFIN:ZDB-GENO-151210-6	Zfish	PMID:26150473
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ak2	IMP	ZFIN:ZDB-GENO-151210-8	Zfish	PMID:26150473
Biological Process	GO:0002521	leukocyte differentiation	ak2	IMP	ZFIN:ZDB-MRPHLNO-090108-2	Zfish	PMID:19043417
Biological Process	GO:0001889	liver development	Ak2	IEP		Rat	PMID:5123889|RGD:5490208
Biological Process	GO:0006119	oxidative phosphorylation	Ak2	IEP		Rat	PMID:18423391|RGD:5147997
Biological Process	GO:0097066	response to thyroid hormone	Ak2	IEP		Rat	PMID:21563808|RGD:5147909

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern