Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKAP12
  • Mouse genes Akap12
  • Rat genes Akap12
  • Zfish genes akap12a,akap12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akap12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008179	adenylate cyclase binding	AKAP12	IPI	UniProtKB:O43306	Human	PMID:17081159
Molecular Function	GO:0008179	adenylate cyclase binding	AKAP12	IPI	UniProtKB:Q8NFM4	Human	PMID:17081159
Molecular Function	GO:0005515	protein binding	AKAP12	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	AKAP12	IPI	UniProtKB:P00533	Human	PMID:31980649
Cellular Component	GO:0005737	cytoplasm	Akap12	IDA		Rat	PMID:11814414|RGD:14348956
Cellular Component	GO:0005737	cytoplasm	akap12b	IDA		Zfish	PMID:17575056
Cellular Component	GO:0005737	cytoplasm	akap12b	IDA		Zfish	PMID:18725198
Cellular Component	GO:0005829	cytosol	AKAP12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	AKAP12	HDA		Human	PMID:21423176
Cellular Component	GO:0043025	neuronal cell body	Akap12	IDA		Rat	PMID:11814414|RGD:14348956
Cellular Component	GO:0048471	perinuclear region of cytoplasm	akap12b	IDA		Zfish	PMID:17575056
Cellular Component	GO:0048471	perinuclear region of cytoplasm	akap12b	IDA		Zfish	PMID:18725198
Cellular Component	GO:0005886	plasma membrane	AKAP12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Akap12	IMP		Mouse	PMID:23238728
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Akap12	IDA		Mouse	PMID:23238728
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Akap12	IEP		Mouse	PMID:23238728
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	AKAP12	IMP		Human	PMID:17081159
Biological Process	GO:0009887	animal organ morphogenesis	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-4	Zfish	PMID:17575056
Biological Process	GO:0032060	bleb assembly	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-4	Zfish	PMID:17575056
Biological Process	GO:0000902	cell morphogenesis	akap12b	IDA		Zfish	PMID:17575056
Biological Process	GO:0071347	cellular response to interleukin-1	Akap12	IEP		Rat	PMID:20454828|RGD:14348957
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Akap12	IEP		Rat	PMID:20454828|RGD:14348957
Biological Process	GO:0060028	convergent extension involved in axis elongation	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-4	Zfish	PMID:17575056
Biological Process	GO:0035733	hepatic stellate cell activation	Akap12	IEP		Rat	PMID:23925424|RGD:14348971
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Akap12	IEP		Mouse	PMID:23238728
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Akap12	IMP		Mouse	PMID:23238728
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Akap12	IDA		Mouse	PMID:23238728
Biological Process	GO:0055001	muscle cell development	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-3	Zfish	PMID:25534553
Biological Process	GO:0055001	muscle cell development	akap12b	IMP	ZFIN:ZDB-MRPHLNO-120404-5	Zfish	PMID:25534553
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-4	Zfish	PMID:17575056
Biological Process	GO:0043116	negative regulation of vascular permeability	Akap12	IMP		Rat	PMID:20454828|RGD:14348957
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Akap12	IMP		Rat	PMID:19937403|RGD:14348968
Biological Process	GO:0061870	positive regulation of hepatic stellate cell migration	Akap12	IMP		Rat	PMID:23925424|RGD:14348971
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Akap12	IMP		Rat	PMID:19937403|RGD:14348968
Biological Process	GO:1900143	positive regulation of oligodendrocyte apoptotic process	Akap12	IMP		Rat	PMID:20155814|RGD:14348972
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Akap12	IMP		Rat	PMID:17873284|RGD:14348969
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Akap12	IMP		Rat	PMID:19937403|RGD:14348968
Biological Process	GO:0010738	regulation of protein kinase A signaling	AKAP12	IMP		Human	PMID:17081159
Biological Process	GO:0051602	response to electrical stimulus	Akap12	IEP		Rat	PMID:23912647|RGD:14348970
Biological Process	GO:0032496	response to lipopolysaccharide	Akap12	IEP		Rat	PMID:23912647|RGD:14348970
Biological Process	GO:0007165	signal transduction	Akap12	IDA		Rat	PMID:12372401|RGD:631986
Biological Process	GO:1904969	slow muscle cell migration	akap12b	IMP	ZFIN:ZDB-MRPHLNO-120404-5	Zfish	PMID:25534553
Biological Process	GO:1904969	slow muscle cell migration	akap12b	IMP	ZFIN:ZDB-MRPHLNO-070910-3	Zfish	PMID:25534553

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern