Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKAP13
  • Mouse genes Akap13
  • Rat genes Akap13
  • Zfish genes akap13,si:dkey-172h23.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akap13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	AKAP13	IDA		Human	PMID:11546812
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	AKAP13	IDA		Human	PMID:25186459
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Akap13	IDA		Mouse	MGI:MGI:5770047|PMID:23658642
Molecular Function	GO:0005078	MAP-kinase scaffold activity	AKAP13	IDA		Human	PMID:21224381
Molecular Function	GO:0005078	MAP-kinase scaffold activity	Akap13	IMP		Rat	PMID:23716597|RGD:11059588
Molecular Function	GO:0060090	molecular adaptor activity	AKAP13	IDA		Human	PMID:23090968
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:P21980	Human	PMID:16301118
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:P31946	Human	PMID:21224381
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:Q9H492	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AKAP13	IPI	UniProtKB:P03372	Human	PMID:9627117
Molecular Function	GO:0051018	protein kinase A binding	AKAP13	IDA		Human	PMID:11546812
Molecular Function	GO:0031267	small GTPase binding	AKAP13	IPI	UniProtKB:P61586	Human	PMID:25186459
Cellular Component	GO:0015629	actin cytoskeleton	Akap13	IDA		Mouse	MGI:MGI:5308772|PMID:20139090
Cellular Component	GO:0005884	actin filament	Akap13	IDA		Mouse	MGI:MGI:5308772|PMID:20139090
Cellular Component	GO:0005938	cell cortex	AKAP13	IDA		Human	PMID:11546812
Cellular Component	GO:0030864	cortical actin cytoskeleton	AKAP13	IDA		Human	PMID:11546812
Cellular Component	GO:0005829	cytosol	AKAP13	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	AKAP13	IDA		Human	PMID:11546812
Cellular Component	GO:0016020	membrane	AKAP13	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Akap13	IDA		Rat	PMID:18951085|RGD:2312638
Biological Process	GO:0086023	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Akap13	IMP		Mouse	MGI:MGI:5770047|PMID:23658642
Biological Process	GO:0071875	adrenergic receptor signaling pathway	AKAP13	IMP		Human	PMID:21224381
Biological Process	GO:0071875	adrenergic receptor signaling pathway	AKAP13	IMP		Human	PMID:23090968
Biological Process	GO:0071875	adrenergic receptor signaling pathway	Akap13	IMP		Rat	PMID:23090968|RGD:11059571
Biological Process	GO:0060348	bone development	Akap13	IMP		Mouse	MGI:MGI:5770225|PMID:25892096
Biological Process	GO:0055007	cardiac muscle cell differentiation	Akap13	IMP		Mouse	MGI:MGI:5308772|PMID:20139090
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Akap13	IMP		Rat	PMID:18951085|RGD:2312638
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AKAP13	IDA		Human	PMID:11546812
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Akap13	IMP		Rat	PMID:20139090|RGD:11059579
Biological Process	GO:0007507	heart development	Akap13	IMP		Mouse	MGI:MGI:5308772|PMID:20139090
Biological Process	GO:0051168	nuclear export	Akap13	IMP		Rat	PMID:18951085|RGD:2312638
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	AKAP13	IMP		Human	PMID:23090968
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Akap13	IMP		Rat	PMID:23090968|RGD:11059571
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Akap13	IMP		Rat	PMID:23716597|RGD:11059588
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	AKAP13	IDA		Human	PMID:11546812
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	AKAP13	IMP		Human	PMID:21224381
Biological Process	GO:1900169	regulation of glucocorticoid mediated signaling pathway	Akap13	IMP	MGI:MGI:5308769	Mouse	PMID:16469733
Biological Process	GO:0060297	regulation of sarcomere organization	Akap13	IMP		Mouse	MGI:MGI:5308772|PMID:20139090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern