Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKAP5
  • Mouse genes Akap5
  • Rat genes Akap5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akap5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Akap5	IDA		Rat	PMID:15930126|RGD:2313226
Molecular Function	GO:0008179	adenylate cyclase binding	AKAP5	IPI	UniProtKB:O43306	Human	PMID:17081159
Molecular Function	GO:0008179	adenylate cyclase binding	AKAP5	IPI	UniProtKB:Q8NFM4	Human	PMID:17081159
Molecular Function	GO:0008179	adenylate cyclase binding	Akap5	IPI	PR:Q01341	Mouse	PMID:20164376
Molecular Function	GO:0008179	adenylate cyclase binding	Akap5	IDA		Rat	PMID:20410303|RGD:7242424
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	Akap5	IPI	UniProtKB:P10608	Rat	PMID:20395454|RGD:12907549
Molecular Function	GO:0045296	cadherin binding	Akap5	IPI	RGD:69279	Rat	PMID:15930126|RGD:2313226
Molecular Function	GO:0001664	G protein-coupled receptor binding	Akap5	IPI	RGD:2059	Rat	PMID:16940053|RGD:2313215
Molecular Function	GO:0050811	GABA receptor binding	Akap5	IDA		Rat	PMID:12595241|RGD:632238
Molecular Function	GO:0035254	glutamate receptor binding	AKAP5	IDA		Human	PMID:10939335
Molecular Function	GO:0035254	glutamate receptor binding	Akap5	IPI	UniProtKB:P19490	Rat	PMID:10939335|RGD:2313285
Molecular Function	GO:0019900	kinase binding	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Molecular Function	GO:0060090	molecular adaptor activity	Akap5	IDA		Mouse	PMID:11943807
Molecular Function	GO:0060090	molecular adaptor activity	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P35561	Human	PMID:11287423
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P13861	Human	PMID:16642035
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P40146	Human	PMID:20410303
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:Q9HBX9	Human	PMID:20664520
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P40146	Human	PMID:21771783
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P13861	Human	PMID:22343722
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:Q08209-1	Human	PMID:22343722
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P40146	Human	PMID:22976297
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P13861	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P31323	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P10644	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:P31323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:Q08209-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:Q96C74	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKAP5	IPI	UniProtKB:Q9HAT0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Akap5	IPI	UniProtKB:P97438	Mouse	MGI:MGI:3703490|PMID:17110924
Molecular Function	GO:0005515	protein binding	Akap5	IPI	UniProtKB:P12367|UniProtKB:P48453	Mouse	MGI:MGI:5447853|PMID:22940692
Molecular Function	GO:0005515	protein binding	Akap5	IPI	UniProtKB:P97490	Mouse	MGI:MGI:6214755|PMID:20410303
Molecular Function	GO:0005515	protein binding	Akap5	IPI	RGD:621504	Rat	PMID:12754513|RGD:632236
Molecular Function	GO:0005515	protein binding	Akap5	IPI	RGD:1311884	Rat	PMID:12938160|RGD:1304429
Molecular Function	GO:0005515	protein binding	Akap5	IPI	RGD:2245	Rat	PMID:17640527|RGD:2313203
Molecular Function	GO:0005515	protein binding	Akap5	IPI	RGD:628841	Rat	PMID:18701070|RGD:2313200
Molecular Function	GO:0005515	protein binding	Akap5	IPI	UniProtKB:P40146	Rat	PMID:20410303|RGD:7242424
Molecular Function	GO:0019904	protein domain specific binding	Akap5	IDA		Rat	PMID:12595241|RGD:632238
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	AKAP5	IPI	UniProtKB:P13861	Human	PMID:17911601
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	AKAP5	IDA		Human	PMID:21502359
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	Akap5	IDA		Rat	PMID:12826266|RGD:2313237
Molecular Function	GO:0019901	protein kinase binding	Akap5	IPI	RGD:3389	Rat	PMID:18381233|RGD:2313201
Molecular Function	GO:0019901	protein kinase binding	Akap5	IDA		Rat	PMID:2538452|RGD:631906
Molecular Function	GO:0030346	protein phosphatase 2B binding	AKAP5	IDA		Human	PMID:10939335
Molecular Function	GO:0030346	protein phosphatase 2B binding	Akap5	IDA		Rat	PMID:10598575|RGD:2313286
Molecular Function	GO:0044877	protein-containing complex binding	Akap5	IPI	RGD:620715|RGD:2060	Rat	PMID:15141163|RGD:2313233
Molecular Function	GO:0044877	protein-containing complex binding	Akap5	IPI	RGD:69280|RGD:70487	Rat	PMID:15930126|RGD:2313226
Molecular Function	GO:0097110	scaffold protein binding	AKAP5	IPI	UniProtKB:P31016	Human	PMID:10939335
Molecular Function	GO:0097110	scaffold protein binding	Akap5	IPI	UniProtKB:P31016	Rat	PMID:10939335|RGD:2313285
Molecular Function	GO:0017124	SH3 domain binding	AKAP5	IPI	UniProtKB:P31016	Human	PMID:10939335
Molecular Function	GO:0017124	SH3 domain binding	Akap5	IPI	UniProtKB:P31016	Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0032279	asymmetric synapse	Akap5	IDA		Rat	PMID:15951119|RGD:2312610
Cellular Component	GO:0016323	basolateral plasma membrane	Akap5	IDA		Rat	PMID:12826266|RGD:2313237
Cellular Component	GO:0005737	cytoplasm	Akap5	IDA		Rat	PMID:16510716|RGD:2313219
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	AKAP5	IDA		Human	PMID:22343722
Cellular Component	GO:0005856	cytoskeleton	Akap5	IDA		Mouse	PMID:20164376
Cellular Component	GO:0030425	dendrite	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0032590	dendrite membrane	Akap5	IDA		Rat	PMID:15930126|RGD:2313226
Cellular Component	GO:0043198	dendritic shaft	Akap5	IDA		Rat	PMID:16510716|RGD:2313219
Cellular Component	GO:0043197	dendritic spine	Akap5	IDA		Rat	PMID:15951119|RGD:2312610
Cellular Component	GO:0032591	dendritic spine membrane	Akap5	IDA		Rat	PMID:12177200|RGD:2313249
Cellular Component	GO:0060076	excitatory synapse	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0031527	filopodium membrane	Akap5	IDA		Rat	PMID:12177200|RGD:2313249
Cellular Component	GO:0098978	glutamatergic synapse	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0098978	glutamatergic synapse	Akap5	IMP		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0098978	glutamatergic synapse	Akap5	IDA		Rat	PMID:19169250|RGD:2313185
Cellular Component	GO:0098978	glutamatergic synapse	Akap5	IMP		Rat	PMID:19169250|RGD:2313185
Cellular Component	GO:0045121	membrane raft	AKAP5	IMP		Human	PMID:21771783
Cellular Component	GO:0043025	neuronal cell body	Akap5	IDA		Rat	PMID:16510716|RGD:2313219
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Akap5	IDA		Rat	PMID:15951119|RGD:2312610
Cellular Component	GO:0005886	plasma membrane	Akap5	IDA		Mouse	PMID:20164376
Cellular Component	GO:0005886	plasma membrane	Akap5	IDA		Rat	PMID:10598575|RGD:2313286
Cellular Component	GO:0005886	plasma membrane	Akap5	IDA		Rat	PMID:22976297|RGD:13800547
Cellular Component	GO:0014069	postsynaptic density	Akap5	IDA		Rat	PMID:16510716|RGD:2313219
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Akap5	IDA		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Akap5	IMP		Rat	PMID:10939335|RGD:2313285
Cellular Component	GO:0098837	postsynaptic recycling endosome	AKAP5	IDA		Human	PMID:25589740
Cellular Component	GO:0098837	postsynaptic recycling endosome	Akap5	IDA		Mouse	PMID:22623657
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	AKAP5	IMP		Human	PMID:17081159
Biological Process	GO:0036394	amylase secretion	Akap5	IMP	MGI:MGI:3766311	Mouse	PMID:20164376
Biological Process	GO:0071417	cellular response to organonitrogen compound	Akap5	IEP		Rat	PMID:19169250|RGD:2313185
Biological Process	GO:0070073	clustering of voltage-gated calcium channels	Akap5	IMP		Mouse	MGI:MGI:6378147|PMID:27693258
Biological Process	GO:0045163	clustering of voltage-gated potassium channels	Akap5	IDA		Mouse	MGI:MGI:6378147|PMID:27693258
Biological Process	GO:0051649	establishment of localization in cell	Akap5	IMP	MGI:MGI:3766311	Mouse	PMID:20164376
Biological Process	GO:0021766	hippocampus development	Akap5	IEP		Rat	PMID:19535604|RGD:2313144
Biological Process	GO:0060135	maternal process involved in female pregnancy	Akap5	IEP		Rat	PMID:12135903|RGD:2313252
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	AKAP5	IMP		Human	PMID:20410303
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	AKAP5	IMP		Human	PMID:21771783
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	Akap5	IDA		Rat	PMID:20410303|RGD:7242424
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	Akap5	IDA		Rat	PMID:22976297|RGD:13800547
Biological Process	GO:0043271	negative regulation of monoatomic ion transport	Akap5	IMP		Rat	PMID:18701070|RGD:2313200
Biological Process	GO:0043267	negative regulation of potassium ion transport	Akap5	IMP		Rat	PMID:16460836|RGD:2313223
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Akap5	IDA		Rat	PMID:20410303|RGD:7242424
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Akap5	IMP		Rat	PMID:22343722|RGD:13507305
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	Akap5	IDA		Rat	PMID:18381233|RGD:2313201
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Akap5	IMP		Rat	PMID:19535604|RGD:2313144
Biological Process	GO:1905751	positive regulation of endosome to plasma membrane protein transport	AKAP5	IMP		Human	PMID:25589740
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	AKAP5	IMP		Human	PMID:25589740
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Akap5	IMP		Rat	PMID:17640527|RGD:2313203
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	AKAP5	IMP		Human	PMID:22343722
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Akap5	IMP		Rat	PMID:18381233|RGD:2313201
Biological Process	GO:0099630	postsynaptic neurotransmitter receptor cycle	Akap5	IMP		Mouse	PMID:22623657
Biological Process	GO:0032984	protein-containing complex disassembly	Akap5	IDA		Rat	PMID:12177200|RGD:2313249
Biological Process	GO:0043113	receptor clustering	Akap5	IDA		Mouse	MGI:MGI:6378147|PMID:27693258
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Akap5	IDA		Rat	PMID:19169250|RGD:2313185
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Akap5	IMP		Rat	PMID:19169250|RGD:2313185
Biological Process	GO:0010738	regulation of protein kinase A signaling	AKAP5	IMP		Human	PMID:17081159
Biological Process	GO:0051602	response to electrical stimulus	Akap5	IEP		Rat	PMID:14732469|RGD:1304289
Biological Process	GO:0014850	response to muscle activity	Akap5	IEP		Rat	PMID:12150937|RGD:2313251
Biological Process	GO:0021510	spinal cord development	Akap5	IEP		Rat	PMID:19535604|RGD:2313144
Biological Process	GO:0007416	synapse assembly	Akap5	IMP		Mouse	PMID:22623657

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern