Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKAP6
  • Mouse genes Akap6
  • Rat genes Akap6
  • Zfish genes akap6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akap6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008179	adenylate cyclase binding	Akap6	IDA		Rat	PMID:19574217|RGD:6902943
Molecular Function	GO:0019899	enzyme binding	Akap6	IPI	UniProtKB:Q08499	Rat	PMID:15182229|RGD:8554179
Molecular Function	GO:0060090	molecular adaptor activity	Akap6	IDA		Rat	PMID:11590243|RGD:1599255
Molecular Function	GO:0005515	protein binding	AKAP6	IPI	UniProtKB:Q91YE8	Human	PMID:17923693
Molecular Function	GO:0005515	protein binding	Akap6	IPI	UniProtKB:Q8VCC8	Mouse	MGI:MGI:5491968|PMID:23540699
Molecular Function	GO:0005515	protein binding	Akap6	IPI	RGD:620546	Rat	PMID:15652351|RGD:2314545
Molecular Function	GO:0005515	protein binding	Akap6	IPI	UniProtKB:P20651	Rat	PMID:19883655|RGD:6902942
Molecular Function	GO:0005515	protein binding	Akap6	IPI	UniProtKB:P48453	Rat	PMID:19883655|RGD:6902942
Molecular Function	GO:0005515	protein binding	Akap6	IPI	RGD:2281	Rat	PMID:20224290|RGD:6902941
Molecular Function	GO:0051018	protein kinase A binding	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Molecular Function	GO:0051018	protein kinase A binding	Akap6	IDA		Rat	PMID:11590243|RGD:1599255
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	Akap6	IDA		Rat	PMID:16306226|RGD:2312613
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Molecular Function	GO:0051721	protein phosphatase 2A binding	Akap6	IDA		Rat	PMID:11590243|RGD:1599255
Molecular Function	GO:0043495	protein-membrane adaptor activity	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Molecular Function	GO:0044325	transmembrane transporter binding	AKAP6	IPI	UniProtKB:Q92736	Human	PMID:10830164
Molecular Function	GO:0044325	transmembrane transporter binding	Akap6	IPI	UniProtKB:B0LPN4	Rat	PMID:11590243|RGD:1599255
Molecular Function	GO:0044325	transmembrane transporter binding	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Cellular Component	GO:0034704	calcium channel complex	AKAP6	IDA		Human	PMID:10830164
Cellular Component	GO:0005901	caveola	Akap6	IDA		Rat	PMID:20224290|RGD:6902941
Cellular Component	GO:0005737	cytoplasm	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Cellular Component	GO:0014704	intercalated disc	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Cellular Component	GO:0014701	junctional sarcoplasmic reticulum membrane	Akap6	IDA		Rat	PMID:12709444|RGD:8554839
Cellular Component	GO:0005635	nuclear envelope	AKAP6	IDA		Human	PMID:10413680
Cellular Component	GO:0005635	nuclear envelope	Akap6	IDA		Rat	PMID:15652351|RGD:2314545
Cellular Component	GO:0005635	nuclear envelope	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Cellular Component	GO:0005635	nuclear envelope	Akap6	IDA		Rat	PMID:11590243|RGD:1599255
Cellular Component	GO:0031965	nuclear membrane	Akap6	IDA		Mouse	PMID:20164376
Cellular Component	GO:0031965	nuclear membrane	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Cellular Component	GO:0005634	nucleus	Akap6	IDA		Rat	PMID:10413680|RGD:69370
Cellular Component	GO:0005634	nucleus	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Cellular Component	GO:0048471	perinuclear region of cytoplasm	AKAP6	IDA		Human	PMID:11590243
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Akap6	IDA		Mouse	MGI:MGI:5499728|PMID:11590243
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Akap6	IDA		Rat	PMID:11296225|RGD:68716
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Akap6	IDA		Rat	PMID:12709444|RGD:8554839
Cellular Component	GO:0032991	protein-containing complex	Akap6	IDA		Rat	PMID:11296225|RGD:68716
Cellular Component	GO:0032991	protein-containing complex	Akap6	IDA		Rat	PMID:16306226|RGD:2312613
Cellular Component	GO:0042383	sarcolemma	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Cellular Component	GO:0016529	sarcoplasmic reticulum	AKAP6	IDA		Human	PMID:10830164
Cellular Component	GO:0016529	sarcoplasmic reticulum	AKAP6	IDA		Human	PMID:7721854
Cellular Component	GO:0016529	sarcoplasmic reticulum	Akap6	IDA		Rat	PMID:7721854|RGD:6902944
Cellular Component	GO:0030315	T-tubule	Akap6	IDA		Rat	PMID:9679148|RGD:8553491
Biological Process	GO:0071320	cellular response to cAMP	AKAP6	IDA		Human	PMID:11299204
Biological Process	GO:0071345	cellular response to cytokine stimulus	Akap6	IMP		Rat	PMID:16177794|RGD:8554301
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Akap6	IMP		Rat	PMID:11179196|RGD:8553373
Biological Process	GO:0007194	negative regulation of adenylate cyclase activity	Akap6	IMP		Rat	PMID:19574217|RGD:6902943
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Akap6	IMP		Rat	PMID:16306226|RGD:2312613
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	Akap6	IMP		Rat	PMID:11179196|RGD:8553373
Biological Process	GO:0030307	positive regulation of cell growth	Akap6	IMP		Rat	PMID:16177794|RGD:8554301
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Akap6	IDA		Rat	PMID:16306226|RGD:2312613
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Akap6	IMP		Rat	PMID:21550986|RGD:6902940
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	AKAP6	IDA		Human	PMID:11299204
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	AKAP6	IDA		Human	PMID:11299204
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Akap6	IMP		Rat	PMID:11179196|RGD:8553373
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Akap6	IMP		Rat	PMID:12709444|RGD:8554839
Biological Process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	Akap6	IDA		Rat	PMID:12709444|RGD:8554839
Biological Process	GO:0045727	positive regulation of translation	Akap6	IMP		Rat	PMID:16306226|RGD:2312613
Biological Process	GO:0031503	protein-containing complex localization	Akap6	IMP		Rat	PMID:11179196|RGD:8553373
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Akap6	IMP		Rat	PMID:11179196|RGD:8553373
Biological Process	GO:0060306	regulation of membrane repolarization	AKAP6	IDA		Human	PMID:11299204
Biological Process	GO:0010738	regulation of protein kinase A signaling	Akap6	IDA		Rat	PMID:12709444|RGD:8554839
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle	Akap6	IMP		Rat	PMID:11179196|RGD:8553373

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern