Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKAP8
  • Mouse genes Akap8
  • Rat genes Akap8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akap8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Molecular Function	GO:0003690	double-stranded DNA binding	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Molecular Function	GO:0042826	histone deacetylase binding	AKAP8	IDA		Human	PMID:16980585
Molecular Function	GO:0051059	NF-kappaB binding	Akap8	IDA		Mouse	MGI:MGI:5763364|PMID:19531803
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:P49736	Human	PMID:12740381
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:P42574	Human	PMID:16227597
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:O15379	Human	PMID:16980585
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:Q15418	Human	PMID:22130794
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:P61964	Human	PMID:23995757
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:Q9C005	Human	PMID:23995757
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:Q9UBL3	Human	PMID:23995757
Molecular Function	GO:0005515	protein binding	AKAP8	IPI	UniProtKB:P13861	Human	PMID:9473338
Molecular Function	GO:0005515	protein binding	Akap8	IPI	UniProtKB:P25799	Mouse	MGI:MGI:5763364|PMID:19531803
Molecular Function	GO:0005515	protein binding	Akap8	IPI	UniProtKB:Q9ERZ6	Mouse	MGI:MGI:3694338|PMID:16751186
Molecular Function	GO:0005515	protein binding	Akap8	IPI	UniProtKB:Q61656	Rat	PMID:11279182|RGD:5128520
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	AKAP8	IPI	UniProtKB:P13861	Human	PMID:17911601
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Molecular Function	GO:0003723	RNA binding	AKAP8	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	AKAP8	HDA		Human	PMID:22681889
Molecular Function	GO:0008270	zinc ion binding	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Cellular Component	GO:0000793	condensed chromosome	Akap8	IDA		Mouse	PMID:12082153
Cellular Component	GO:0001939	female pronucleus	Akap8	IDA		Mouse	PMID:12082153
Cellular Component	GO:0005794	Golgi apparatus	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Cellular Component	GO:0016020	membrane	AKAP8	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Cellular Component	GO:0016363	nuclear matrix	Akap8	IDA		Mouse	MGI:MGI:3694338|PMID:16751186
Cellular Component	GO:0016363	nuclear matrix	Akap8	IDA		Rat	PMID:8125992|RGD:724798
Cellular Component	GO:0005730	nucleolus	AKAP8	IDA		Human	PMID:26683827
Cellular Component	GO:0005654	nucleoplasm	AKAP8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Akap8	IDA		Mouse	PMID:12082153
Biological Process	GO:0044839	cell cycle G2/M phase transition	AKAP8	IMP		Human	PMID:16980585
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Akap8	IMP		Mouse	MGI:MGI:5763364|PMID:19531803
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	Akap8	IMP		Mouse	MGI:MGI:5763364|PMID:19531803
Biological Process	GO:0007076	mitotic chromosome condensation	Akap8	IDA		Mouse	PMID:12082153
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Akap8	IMP		Mouse	MGI:MGI:5763364|PMID:19531803
Biological Process	GO:0031065	positive regulation of histone deacetylation	AKAP8	IMP		Human	PMID:16980585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern