Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKR1A1
  • Mouse genes Akr1a1
  • Rat genes Akr1a1
  • Zfish genes akr1a1a,akr1a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akr1a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Akr1a1	IDA		Mouse	PMID:14667815
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Akr1a1	IDA		Mouse	PMID:15769935
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-3	Zfish	PMID:33251496
Molecular Function	GO:0047941	glucuronolactone reductase activity	AKR1A1	IDA		Human	PMID:10510318
Molecular Function	GO:0047941	glucuronolactone reductase activity	Akr1a1	IDA		Mouse	MGI:MGI:5439044|PMID:22820017
Molecular Function	GO:0047941	glucuronolactone reductase activity	Akr1a1	IDA		Rat	PMID:22820017|RGD:13825440
Molecular Function	GO:0047939	L-glucuronate reductase activity	AKR1A1	IDA		Human	PMID:10510318
Molecular Function	GO:0047939	L-glucuronate reductase activity	AKR1A1	EXP		Human	PMID:7669785
Molecular Function	GO:0047939	L-glucuronate reductase activity	Akr1a1	IDA		Mouse	PMID:15769935
Molecular Function	GO:0047939	L-glucuronate reductase activity	Akr1a1	IMP	MGI:MGI:4239556	Mouse	PMID:20410296
Molecular Function	GO:0047939	L-glucuronate reductase activity	Akr1a1	IDA		Rat	PMID:22820017|RGD:13825440
Molecular Function	GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	Akr1a1	IMP		Mouse	PMID:31649033
Molecular Function	GO:0005515	protein binding	AKR1A1	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	AKR1A1	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AKR1A1	IPI	UniProtKB:P42858	Human	PMID:32814053
Cellular Component	GO:0016324	apical plasma membrane	Akr1a1	IDA		Mouse	PMID:15769935
Cellular Component	GO:0005829	cytosol	Akr1a1	IDA		Mouse	PMID:15769935
Cellular Component	GO:0005829	cytosol	Akr1a1	IDA		Mouse	PMID:38160
Cellular Component	GO:0070062	extracellular exosome	AKR1A1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	AKR1A1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	AKR1A1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	AKR1A1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	AKR1A1	HDA		Human	PMID:23580065
Cellular Component	GO:0045202	synapse	Akr1a1	EXP		Mouse	PMID:16635246
Cellular Component	GO:0045202	synapse	Akr1a1	IDA		Mouse	PMID:16635246
Biological Process	GO:0046185	aldehyde catabolic process	Akr1a1	IDA		Mouse	PMID:15769935
Biological Process	GO:0110095	cellular detoxification of aldehyde	Akr1a1	IMP		Mouse	MGI:MGI:5439044|PMID:22820017
Biological Process	GO:0110095	cellular detoxification of aldehyde	Akr1a1	IDA		Rat	PMID:25152401|RGD:13838799
Biological Process	GO:0042840	D-glucuronate catabolic process	Akr1a1	IDA		Mouse	PMID:15769935
Biological Process	GO:0042840	D-glucuronate catabolic process	Akr1a1	IMP		Rat	PMID:22820017|RGD:13825440
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1A1	IDA		Human	PMID:18276838
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1A1	IDA		Human	PMID:18276838
Biological Process	GO:0042593	glucose homeostasis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-4	Zfish	PMID:33251496
Biological Process	GO:0042593	glucose homeostasis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-7	Zfish	PMID:33251496
Biological Process	GO:0042593	glucose homeostasis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-3	Zfish	PMID:33251496
Biological Process	GO:0019640	glucuronate catabolic process to xylulose 5-phosphate	Akr1a1	IDA		Mouse	PMID:38160
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Akr1a1	IMP	MGI:MGI:4239556	Mouse	PMID:20410296
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Akr1a1	IDA		Mouse	PMID:15769935
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Akr1a1	IMP		Rat	PMID:22820017|RGD:13825440
Biological Process	GO:0043066	negative regulation of apoptotic process	Akr1a1	IDA		Rat	PMID:9538214|RGD:9685737
Biological Process	GO:0006111	regulation of gluconeogenesis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-3	Zfish	PMID:33251496
Biological Process	GO:0006111	regulation of gluconeogenesis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-4	Zfish	PMID:33251496
Biological Process	GO:0006111	regulation of gluconeogenesis	akr1a1b	IMP	ZFIN:ZDB-GENO-220506-7	Zfish	PMID:33251496

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern