Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKR1C1,AKR1C2,AKR1C4
  • Mouse genes Akr1c21
  • Rat genes Akr1c2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akr1c21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0072555	17-beta-ketosteroid reductase activity	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0047024	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	AKR1C2	IDA		Human	PMID:21232532
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	AKR1C1	IDA		Human	PMID:21232532
Molecular Function	GO:0047042	androsterone dehydrogenase (B-specific) activity	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0047023	androsterone dehydrogenase activity	AKR1C4	IDA		Human	PMID:21851338
Molecular Function	GO:0047023	androsterone dehydrogenase activity	Akr1c21	IDA		Mouse	MGI:MGI:5426779|PMID:15577209
Molecular Function	GO:0047023	androsterone dehydrogenase activity	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0032052	bile acid binding	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0032052	bile acid binding	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0031406	carboxylic acid binding	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0031406	carboxylic acid binding	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0047743	chlordecone reductase activity	AKR1C4	IDA		Human	PMID:2427522
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	AKR1C2	IDA		Human	PMID:21232532
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	AKR1C1	IDA		Human	PMID:21232532
Molecular Function	GO:1902121	lithocholic acid binding	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0070401	NADP+ binding	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0070402	NADPH binding	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C4	IDA		Human	PMID:20837989
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C2	IDA		Human	PMID:20837989
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C1	IDA		Human	PMID:19442656
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C1	IDA		Human	PMID:20837989
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	AKR1C2	IDA		Human	PMID:21851338
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	AKR1C1	IDA		Human	PMID:21851338
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:P26045	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:P26045	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0001758	retinal dehydrogenase activity	AKR1C4	IDA		Human	PMID:21851338
Molecular Function	GO:0005496	steroid binding	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Akr1c21	IDA		Mouse	PMID:17442338
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Akr1c21	IDA		Mouse	PMID:17034817
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1	IDA		Human	PMID:8486699
Cellular Component	GO:0005829	cytosol	AKR1C1	IDA		Human	PMID:8486699
Cellular Component	GO:0070062	extracellular exosome	AKR1C4	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	AKR1C1	HDA		Human	PMID:23533145
Biological Process	GO:0008206	bile acid metabolic process	AKR1C1	IDA		Human	PMID:8486699
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C4	IDA		Human	PMID:19487289
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C2	IDA		Human	PMID:19487289
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C1	IDA		Human	PMID:19487289
Biological Process	GO:0071799	cellular response to prostaglandin D stimulus	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C4	IMP		Human	PMID:20837989
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C2	IMP		Human	PMID:20837989
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C1	IMP		Human	PMID:20837989
Biological Process	GO:0007586	digestion	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0007586	digestion	AKR1C1	IDA		Human	PMID:8486699
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C4	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C2	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C1	IMP		Human	PMID:20837989
Biological Process	GO:0030855	epithelial cell differentiation	AKR1C2	IEP		Human	PMID:21492153
Biological Process	GO:0030855	epithelial cell differentiation	AKR1C1	IDA		Human	PMID:21492153
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	AKR1C1	IDA		Human	PMID:19442656
Biological Process	GO:0042448	progesterone metabolic process	AKR1C2	IDA		Human	PMID:21232532
Biological Process	GO:0042448	progesterone metabolic process	AKR1C1	IDA		Human	PMID:21232532
Biological Process	GO:0006693	prostaglandin metabolic process	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0046683	response to organophosphorus	AKR1C1	IEP		Human	PMID:16079077
Biological Process	GO:0042574	retinal metabolic process	AKR1C1	IDA		Human	PMID:21851338
Biological Process	GO:0008202	steroid metabolic process	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0008202	steroid metabolic process	Akr1c21	IMP		Mouse	MGI:MGI:5883408|PMID:20124700

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern