Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKR1C1,AKR1C2,AKR1C3,AKR1C4
  • Mouse genes Akr1c6
  • Rat genes Akr1c1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akr1c6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C3	IDA		Human	PMID:22170488
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	Akr1c1	IDA		Rat	PMID:16788056|RGD:1626149
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	AKR1C3	IDA		Human	PMID:21232532
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	AKR1C2	IDA		Human	PMID:21232532
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	AKR1C1	IDA		Human	PMID:21232532
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	AKR1C3	IDA		Human	PMID:9792917
Molecular Function	GO:0047042	androsterone dehydrogenase (B-specific) activity	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0047023	androsterone dehydrogenase activity	AKR1C4	IDA		Human	PMID:21851338
Molecular Function	GO:0047023	androsterone dehydrogenase activity	AKR1C3	IDA		Human	PMID:16983398
Molecular Function	GO:0032052	bile acid binding	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0032052	bile acid binding	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0031406	carboxylic acid binding	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0031406	carboxylic acid binding	AKR1C1	IDA		Human	PMID:8486699
Molecular Function	GO:0047743	chlordecone reductase activity	AKR1C4	IDA		Human	PMID:2427522
Molecular Function	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	AKR1C3	IDA		Human	PMID:16983398
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	AKR1C3	IDA		Human	PMID:16983398
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	Akr1c6	IDA		Mouse	PMID:7737980
Molecular Function	GO:0045550	geranylgeranyl reductase activity	AKR1C3	IDA		Human	PMID:21187079
Molecular Function	GO:0045703	ketoreductase activity	AKR1C3	IDA		Human	PMID:19487289
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	AKR1C3	IDA		Human	PMID:21232532
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	AKR1C2	IDA		Human	PMID:21232532
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	AKR1C1	IDA		Human	PMID:21232532
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	AKR1C3	IDA		Human	PMID:21851338
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C4	IDA		Human	PMID:20837989
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C3	IDA		Human	PMID:19442656
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C3	IDA		Human	PMID:20837989
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C2	IDA		Human	PMID:20837989
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C1	IDA		Human	PMID:19442656
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	AKR1C1	IDA		Human	PMID:20837989
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	AKR1C3	IDA		Human	PMID:21851338
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	AKR1C2	IDA		Human	PMID:21851338
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	AKR1C1	IDA		Human	PMID:21851338
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:P26045	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:P26045	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR1C1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0001758	retinal dehydrogenase activity	AKR1C4	IDA		Human	PMID:21851338
Molecular Function	GO:0001758	retinal dehydrogenase activity	AKR1C3	IDA		Human	PMID:21851338
Molecular Function	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	Akr1c1	IDA		Rat	PMID:16788056|RGD:1626149
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C2	IDA		Human	PMID:8573067
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1	IDA		Human	PMID:8486699
Cellular Component	GO:0005737	cytoplasm	AKR1C3	IDA		Human	PMID:18574251
Cellular Component	GO:0005737	cytoplasm	AKR1C3	IDA		Human	PMID:19336506
Cellular Component	GO:0005737	cytoplasm	AKR1C3	IDA		Human	PMID:19942269
Cellular Component	GO:0005737	cytoplasm	AKR1C3	IDA		Human	PMID:22170488
Cellular Component	GO:0005737	cytoplasm	Akr1c1	IDA		Rat	PMID:18574251|RGD:8554615
Cellular Component	GO:0005829	cytosol	AKR1C1	IDA		Human	PMID:8486699
Cellular Component	GO:0070062	extracellular exosome	AKR1C4	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	AKR1C3	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	AKR1C1	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	AKR1C3	IDA		Human	PMID:18574251
Cellular Component	GO:0005634	nucleus	Akr1c1	IDA		Rat	PMID:18574251|RGD:8554615
Biological Process	GO:0008206	bile acid metabolic process	AKR1C1	IDA		Human	PMID:8486699
Biological Process	GO:0071276	cellular response to cadmium ion	AKR1C3	IDA		Human	PMID:21787718
Biological Process	GO:0071277	cellular response to calcium ion	AKR1C3	IDA		Human	PMID:22170488
Biological Process	GO:0071384	cellular response to corticosteroid stimulus	AKR1C3	IDA		Human	PMID:19336506
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C4	IDA		Human	PMID:19487289
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C3	IDA		Human	PMID:19487289
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C2	IDA		Human	PMID:19487289
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus	AKR1C1	IDA		Human	PMID:19487289
Biological Process	GO:0071799	cellular response to prostaglandin D stimulus	AKR1C3	IDA		Human	PMID:18508192
Biological Process	GO:0071799	cellular response to prostaglandin D stimulus	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:0071379	cellular response to prostaglandin stimulus	AKR1C3	IDA		Human	PMID:22170488
Biological Process	GO:0034614	cellular response to reactive oxygen species	AKR1C3	IDA		Human	PMID:21787718
Biological Process	GO:0009267	cellular response to starvation	AKR1C3	IEP		Human	PMID:18641923
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C4	IMP		Human	PMID:20837989
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C3	IMP		Human	PMID:20837989
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C2	IMP		Human	PMID:20837989
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1C1	IMP		Human	PMID:20837989
Biological Process	GO:0007586	digestion	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0007586	digestion	AKR1C1	IDA		Human	PMID:8486699
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C4	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C3	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C2	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1C1	IMP		Human	PMID:20837989
Biological Process	GO:0030855	epithelial cell differentiation	AKR1C2	IEP		Human	PMID:21492153
Biological Process	GO:0030855	epithelial cell differentiation	AKR1C1	IDA		Human	PMID:21492153
Biological Process	GO:0016488	farnesol catabolic process	AKR1C3	IDA		Human	PMID:21187079
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AKR1C3	IDA		Human	PMID:18508192
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:0030216	keratinocyte differentiation	AKR1C3	IEP		Human	PMID:22170488
Biological Process	GO:0043170	macromolecule metabolic process	AKR1C3	IEP		Human	PMID:18641923
Biological Process	GO:0008584	male gonad development	AKR1C3	IEP		Human	PMID:19942269
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	Akr1c6	IMP		Mouse	PMID:23636947
Biological Process	GO:1900053	negative regulation of retinoic acid biosynthetic process	AKR1C3	IDA		Human	PMID:21851338
Biological Process	GO:0010942	positive regulation of cell death	AKR1C3	IDA		Human	PMID:21787718
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKR1C3	IDA		Human	PMID:18508192
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKR1C3	IDA		Human	PMID:20036328
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKR1C3	IMP		Human	PMID:21851338
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	AKR1C3	IDA		Human	PMID:19442656
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	AKR1C3	IDA		Human	PMID:18508192
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	AKR1C2	IDA		Human	PMID:18508192
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	AKR1C3	IDA		Human	PMID:19442656
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	AKR1C1	IDA		Human	PMID:19442656
Biological Process	GO:0042448	progesterone metabolic process	AKR1C3	IDA		Human	PMID:21232532
Biological Process	GO:0042448	progesterone metabolic process	AKR1C2	IDA		Human	PMID:21232532
Biological Process	GO:0042448	progesterone metabolic process	AKR1C1	IDA		Human	PMID:21232532
Biological Process	GO:0006693	prostaglandin metabolic process	AKR1C3	IEP		Human	PMID:20036328
Biological Process	GO:0006693	prostaglandin metabolic process	AKR1C3	IDA		Human	PMID:9792917
Biological Process	GO:0006693	prostaglandin metabolic process	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0048385	regulation of retinoic acid receptor signaling pathway	AKR1C3	IDA		Human	PMID:21851338
Biological Process	GO:2000224	regulation of testosterone biosynthetic process	AKR1C3	IMP		Human	PMID:19336506
Biological Process	GO:0043627	response to estrogen	Akr1c1	IDA		Rat	PMID:16788056|RGD:1626149
Biological Process	GO:0007584	response to nutrient	AKR1C3	IEP		Human	PMID:19007764
Biological Process	GO:0046683	response to organophosphorus	AKR1C1	IEP		Human	PMID:16079077
Biological Process	GO:0009410	response to xenobiotic stimulus	Akr1c1	IDA		Rat	PMID:16788056|RGD:1626149
Biological Process	GO:0042574	retinal metabolic process	AKR1C3	IDA		Human	PMID:21851338
Biological Process	GO:0042574	retinal metabolic process	AKR1C1	IDA		Human	PMID:21851338
Biological Process	GO:0008202	steroid metabolic process	AKR1C3	IEP		Human	PMID:20036328
Biological Process	GO:0008202	steroid metabolic process	AKR1C2	IDA		Human	PMID:8573067
Biological Process	GO:0008202	steroid metabolic process	Akr1c6	IDA		Mouse	PMID:7737980
Biological Process	GO:0061370	testosterone biosynthetic process	AKR1C3	IMP		Human	PMID:16983398

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern