Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKR7A2,AKR7A3,AKR7L
  • Mouse genes Akr7a5
  • Rat genes Akr7a2
  • Zfish genes akr7a3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akr7a5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Akr7a2	IDA		Rat	PMID:12071861|RGD:625492
Molecular Function	GO:0042802	identical protein binding	AKR7A3	IPI	UniProtKB:O95154	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	AKR7A3	IPI	UniProtKB:O95154	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	AKR7A3	IPI	UniProtKB:O95154	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	AKR7A3	IPI	UniProtKB:O95154	Human	PMID:32296183
Molecular Function	GO:0019119	phenanthrene-9,10-epoxide hydrolase activity	AKR7A2	IDA		Human	PMID:20837989
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:O95154	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:O95154	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:Q8WWM9	Human	PMID:28536627
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:O95154	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:Q9Y2K1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:O95154	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:Q9Y2K1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:P54252	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AKR7A2	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:O43488	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:O43488	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:O43488	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:O43488	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKR7A3	IPI	UniProtKB:Q15323	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Akr7a2	IDA		Rat	PMID:11597610|RGD:14349051
Cellular Component	GO:0005829	cytosol	AKR7A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	AKR7A3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	AKR7A2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	AKR7A2	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	AKR7A3	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	AKR7A3	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	AKR7L	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	AKR7A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	AKR7A3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	Akr7a2	IDA		Rat	PMID:12071861|RGD:625492
Cellular Component	GO:0005739	mitochondrion	Akr7a5	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Akr7a5	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005635	nuclear envelope	Akr7a2	IDA		Rat	PMID:11597610|RGD:14349051
Biological Process	GO:0044597	daunorubicin metabolic process	AKR7A2	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR7A2	IMP		Human	PMID:20837989

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern