Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Akt2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes AKT2
- Mouse genes Akt2
- Rat genes Akt2
- Zfish genes akt2,akt2l
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	AKT2	IDA		Human	PMID:16540465
Molecular Function	GO:0005524	ATP binding	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Molecular Function	GO:0005524	ATP binding	Akt2	IDA		Rat	PMID:9887206\|RGD:2306431
Molecular Function	GO:0140677	molecular function activator activity	AKT2	EXP		Human	PMID:12517337
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q9UKG1	Human	PMID:10490823
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:O95988	Human	PMID:10983986
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P56278	Human	PMID:10983986
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P56279	Human	PMID:10983986
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P49841	Human	PMID:12434148
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P55160	Human	PMID:16417406
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q96P53	Human	PMID:16792529
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q9UKG1	Human	PMID:17030088
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q9Y4K3	Human	PMID:19713527
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P53804	Human	PMID:20059950
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P08670	Human	PMID:20856200
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:O14908,UniProtKB:Q9UKG1	Human	PMID:21291857
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q9GZV1	Human	PMID:21737686
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:P13639	Human	PMID:23823123
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:O60504	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	AKT2	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q8K4K2	Mouse	MGI:MGI:3687885\|PMID:12791994
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q8BUB4	Mouse	MGI:MGI:5693231\|PMID:16792529
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:B9EHT4	Mouse	MGI:MGI:3836212\|PMID:19139280
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q8CDD8	Mouse	MGI:MGI:5586787\|PMID:24156551
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q9WV06	Mouse	MGI:MGI:5317372\|PMID:21737686
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q80X66	Mouse	MGI:MGI:5586799\|PMID:18160256
Molecular Function	GO:0005515	protein binding	Akt2	IPI	RGD:1587490	Rat	PMID:15684423\|RGD:11039445
Molecular Function	GO:0005515	protein binding	Akt2	IPI	RGD:3664	Rat	PMID:15684423\|RGD:11039445
Molecular Function	GO:0005515	protein binding	Akt2	IPI	RGD:1309388	Rat	PMID:17848569\|RGD:2313331
Molecular Function	GO:0005515	protein binding	Akt2	IPI	UniProtKB:Q9UKG1	Rat	PMID:17848569\|RGD:2313331
Molecular Function	GO:0004672	protein kinase activity	Akt2	IDA		Mouse	PMID:21907143
Molecular Function	GO:0005080	protein kinase C binding	Akt2	IPI	RGD:2801	Rat	PMID:7488143\|RGD:62386
Molecular Function	GO:0005080	protein kinase C binding	Akt2	IPI	RGD:62390	Rat	PMID:7488143\|RGD:62386
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AKT2	IDA		Human	PMID:10983986
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AKT2	IDA		Human	PMID:16540465
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt2	EXP		Mouse	MGI:MGI:5770068\|PMID:19372382
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt2	IDA		Mouse	PMID:21148297
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt2	IDA		Rat	PMID:16445997\|RGD:1581310
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt2	IDA		Rat	PMID:9887206\|RGD:2306431
Cellular Component	GO:0005938	cell cortex	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Cellular Component	GO:0005829	cytosol	AKT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Akt2	IDA		Rat	PMID:16445997\|RGD:1581310
Cellular Component	GO:0005829	cytosol	Akt2	IDA		Rat	PMID:9516411\|RGD:2306429
Cellular Component	GO:0005829	cytosol	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Cellular Component	GO:0032593	insulin-responsive compartment	Akt2	IDA		Rat	PMID:9516411\|RGD:2306429
Cellular Component	GO:0032593	insulin-responsive compartment	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	AKT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Akt2	IDA		Rat	PMID:18335029\|RGD:2313325
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Akt2	IDA		Rat	PMID:9516411\|RGD:2306429
Cellular Component	GO:0005739	mitochondrion	Akt2	IDA		Rat	PMID:29676955\|RGD:13703029
Cellular Component	GO:0005654	nucleoplasm	AKT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	AKT2	IDA		Human	PMID:20059950
Cellular Component	GO:0005634	nucleus	Akt2	IDA		Rat	PMID:29676955\|RGD:13703029
Cellular Component	GO:0005886	plasma membrane	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Cellular Component	GO:0005886	plasma membrane	Akt2	IDA		Rat	PMID:16445997\|RGD:1581310
Cellular Component	GO:0005886	plasma membrane	Akt2	IDA		Rat	PMID:9516411\|RGD:2306429
Cellular Component	GO:0032991	protein-containing complex	AKT2	IDA		Human	PMID:10983986
Cellular Component	GO:0032587	ruffle membrane	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Cellular Component	GO:0016529	sarcoplasmic reticulum	Akt2	IDA		Rat	PMID:29676955\|RGD:13703029
Cellular Component	GO:0031982	vesicle	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Biological Process	GO:0090630	activation of GTPase activity	Akt2	IGI	MGI:MGI:3036245	Mouse	PMID:21148297
Biological Process	GO:0090630	activation of GTPase activity	Akt2	IGI	MGI:MGI:2444531	Mouse	PMID:21148297
Biological Process	GO:0060348	bone development	akt2	IMP	ZFIN:ZDB-GENO-171009-5	Zfish	PMID:28132765
Biological Process	GO:0060348	bone development	akt2	IMP	ZFIN:ZDB-GENO-171009-4	Zfish	PMID:28132765
Biological Process	GO:0071486	cellular response to high light intensity	Akt2	IMP	MGI:MGI:2158456	Mouse	PMID:17202487
Biological Process	GO:0032870	cellular response to hormone stimulus	Akt2	IEP		Rat	PMID:15196698\|RGD:1641994
Biological Process	GO:0032869	cellular response to insulin stimulus	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0032869	cellular response to insulin stimulus	Akt2	IDA		Mouse	MGI:MGI:5292403\|PMID:21907143
Biological Process	GO:0032869	cellular response to insulin stimulus	Akt2	IMP		Rat	PMID:17715136\|RGD:8553574
Biological Process	GO:0071407	cellular response to organic cyclic compound	Akt2	IDA		Rat	PMID:11812651\|RGD:2313392
Biological Process	GO:0042593	glucose homeostasis	akt2	IMP	ZFIN:ZDB-GENO-171009-5	Zfish	PMID:28132765
Biological Process	GO:0042593	glucose homeostasis	akt2	IMP	ZFIN:ZDB-GENO-171009-4	Zfish	PMID:28132765
Biological Process	GO:0006006	glucose metabolic process	Akt2	IMP	MGI:MGI:2158456	Mouse	PMID:17202487
Biological Process	GO:0008286	insulin receptor signaling pathway	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0008286	insulin receptor signaling pathway	Akt2	IDA		Mouse	PMID:21148297
Biological Process	GO:0065002	intracellular protein transmembrane transport	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Biological Process	GO:0043066	negative regulation of apoptotic process	AKT2	IMP		Human	PMID:10983986
Biological Process	GO:0043066	negative regulation of apoptotic process	Akt2	IMP		Rat	PMID:19084003\|RGD:2313316
Biological Process	GO:0043066	negative regulation of apoptotic process	akt2	IMP	ZFIN:ZDB-MRPHLNO-100621-7	Zfish	PMID:20356836
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Akt2	IMP		Rat	PMID:18348079\|RGD:2313324
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0033119	negative regulation of RNA splicing	Akt2	IMP		Rat	PMID:19116344\|RGD:2313309
Biological Process	GO:0032287	peripheral nervous system myelin maintenance	Akt2	IMP		Mouse	PMID:20448149
Biological Process	GO:0030335	positive regulation of cell migration	AKT2	IDA		Human	PMID:25428377
Biological Process	GO:0030335	positive regulation of cell migration	Akt2	IMP		Rat	PMID:19330838\|RGD:2313297
Biological Process	GO:2000147	positive regulation of cell motility	AKT2	IMP		Human	PMID:17332325
Biological Process	GO:0008284	positive regulation of cell population proliferation	AKT2	IMP		Human	PMID:10983986
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0010628	positive regulation of gene expression	Akt2	IMP		Rat	PMID:15557754\|RGD:2313420
Biological Process	GO:0046326	positive regulation of glucose import	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0046326	positive regulation of glucose import	Akt2	IGI	MGI:MGI:1921991	Mouse	PMID:21907143
Biological Process	GO:0046326	positive regulation of glucose import	Akt2	IMP		Rat	PMID:18335029\|RGD:2313325
Biological Process	GO:0046326	positive regulation of glucose import	akt2	IMP	ZFIN:ZDB-MRPHLNO-100621-7	Zfish	PMID:20356836
Biological Process	GO:0010907	positive regulation of glucose metabolic process	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	AKT2	IMP		Human	PMID:16814735
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	AKT2	IMP		Human	PMID:10983986
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Akt2	IMP		Rat	PMID:18335029\|RGD:2313325
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Akt2	IMP		Rat	PMID:18348079\|RGD:2313324
Biological Process	GO:0050927	positive regulation of positive chemotaxis	Akt2	IDA		Rat	PMID:19330838\|RGD:2313297
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Akt2	IDA		Mouse	MGI:MGI:5292403\|PMID:21907143
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Akt2	IMP		Rat	PMID:19116344\|RGD:2313309
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Biological Process	GO:0009967	positive regulation of signal transduction	Akt2	IMP		Rat	PMID:19084003\|RGD:2313316
Biological Process	GO:0010765	positive regulation of sodium ion transport	Akt2	IMP		Rat	PMID:17715136\|RGD:8553574
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Akt2	IMP		Rat	PMID:16469952\|RGD:2313348
Biological Process	GO:0031340	positive regulation of vesicle fusion	Akt2	IMP		Mouse	MGI:MGI:5292403\|PMID:21907143
Biological Process	GO:0043491	protein kinase B signaling	Akt2	IMP		Rat	PMID:16469952\|RGD:2313348
Biological Process	GO:0072659	protein localization to plasma membrane	Akt2	IGI	MGI:MGI:1921991	Mouse	PMID:21907143
Biological Process	GO:0006468	protein phosphorylation	Akt2	IDA		Mouse	PMID:21907143
Biological Process	GO:0006468	protein phosphorylation	Akt2	IDA		Rat	PMID:16445997\|RGD:1581310
Biological Process	GO:0006468	protein phosphorylation	Akt2	IDA		Rat	PMID:9880520\|RGD:2306430
Biological Process	GO:0006468	protein phosphorylation	Akt2	IDA		Rat	PMID:9887206\|RGD:2306431
Biological Process	GO:0001666	response to hypoxia	Akt2	IEP		Rat	PMID:29676955\|RGD:13703029
Biological Process	GO:0032868	response to insulin	Akt2	IDA		Rat	PMID:15684423\|RGD:11039445
Biological Process	GO:0032868	response to insulin	Akt2	IEP		Rat	PMID:18335029\|RGD:2313325
Biological Process	GO:0014850	response to muscle activity	Akt2	IEP		Rat	PMID:11809761\|RGD:2313393
Biological Process	GO:0031667	response to nutrient levels	Akt2	IEP		Rat	PMID:18094069\|RGD:2313329
Biological Process	GO:0006970	response to osmotic stress	Akt2	IEP		Rat	PMID:19251051\|RGD:2313404
Biological Process	GO:0097473	retinal rod cell apoptotic process	Akt2	IMP	MGI:MGI:2158456	Mouse	PMID:17202487

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.