Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKT3
  • Mouse genes Akt3
  • Rat genes Akt3
  • Zfish genes akt3a,akt3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akt3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	AKT3	IDA		Human	PMID:16540465
Molecular Function	GO:0005524	ATP binding	Akt3	IDA		Rat	PMID:9887206|RGD:2306431
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:Q16543	Human	PMID:12176997
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:P42574	Human	PMID:17544405
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:Q9Y4K3	Human	PMID:19713527
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:P53804	Human	PMID:20059950
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	AKT3	IPI	UniProtKB:P42574	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	Akt3	IPI	UniProtKB:Q80X66	Mouse	MGI:MGI:5586799|PMID:18160256
Molecular Function	GO:0005515	protein binding	Akt3	IPI	UniProtKB:Q8CDD8	Mouse	MGI:MGI:5586787|PMID:24156551
Molecular Function	GO:0005080	protein kinase C binding	Akt3	IPI	RGD:2081	Rat	PMID:7488143|RGD:62386
Molecular Function	GO:0005080	protein kinase C binding	Akt3	IPI	RGD:2082	Rat	PMID:7488143|RGD:62386
Molecular Function	GO:0004674	protein serine/threonine kinase activity	AKT3	IDA		Human	PMID:16540465
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt3	IDA		Rat	PMID:7488143|RGD:62386
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Akt3	IDA		Rat	PMID:9887206|RGD:2306431
Biological Process	GO:0048854	brain morphogenesis	Akt3	IMP	MGI:MGI:3574346	Mouse	PMID:15713641
Biological Process	GO:0032869	cellular response to insulin stimulus	Akt3	IMP		Rat	PMID:17715136|RGD:8553574
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Akt3	IMP	MGI:MGI:3574346	Mouse	PMID:15713641
Biological Process	GO:0000002	mitochondrial genome maintenance	AKT3	IMP		Human	PMID:18524868
Biological Process	GO:2000773	negative regulation of cellular senescence	AKT3	IMP		Human	PMID:25323119
Biological Process	GO:0045766	positive regulation of angiogenesis	Akt3	IMP		Mouse	MGI:MGI:6115146|PMID:28254819
Biological Process	GO:1905653	positive regulation of artery morphogenesis	Akt3	IMP		Mouse	MGI:MGI:6115146|PMID:28254819
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	AKT3	IDA		Human	PMID:28254819
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	AKT3	IMP		Human	PMID:25323119
Biological Process	GO:0045793	positive regulation of cell size	Akt3	IMP	MGI:MGI:3574346	Mouse	PMID:15713641
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	AKT3	IMP		Human	PMID:25323119
Biological Process	GO:0010765	positive regulation of sodium ion transport	Akt3	IMP		Rat	PMID:17715136|RGD:8553574
Biological Process	GO:0032008	positive regulation of TOR signaling	Akt3	IMP	MGI:MGI:3574346	Mouse	PMID:15713641
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	AKT3	IDA		Human	PMID:28254819
Biological Process	GO:0006468	protein phosphorylation	Akt3	IDA		Rat	PMID:9887206|RGD:2306431
Biological Process	GO:0007165	signal transduction	AKT3	IMP		Human	PMID:18524868

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern