Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALAS1
  • Mouse genes Alas1
  • Rat genes Alas1
  • Zfish genes alas1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alas1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS1	IDA		Human	PMID:16234850
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ALAS1	IDA		Human	PMID:17975826
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas1	IDA		Rat	PMID:16125296|RGD:1601233
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	Alas1	IDA		Rat	PMID:3182776|RGD:632013
Molecular Function	GO:0042802	identical protein binding	ALAS1	IPI	UniProtKB:P13196	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	ALAS1	IPI	UniProtKB:P13196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WTR2	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q96L91	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9Y2S7	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O43516	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O60437	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:P63313	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q0P5Q0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q15560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q17RB0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q17RB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q4VC05	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q5W5X9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q68DK2-5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6P1J9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6P444	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6PF15	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q7Z614	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8TBZ8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8TCT0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8TD31-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WTR2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WW24	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q96L91	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9H788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9NVN8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9NWW7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9Y2K6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9Y2S7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9Y473	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6P1J9	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WTR2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6P1J9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:A0A0A0MR80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:A8MXD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:C9JCN9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O60437	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O75128	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O75564-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:P08579	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:P40123	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:P63313	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q17RB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q4G0R1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q5TAP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q765P7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8IYW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8TBZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WTR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q96CD0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q96CN5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9HAQ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9Y473	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q6PF15	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALAS1	IPI	UniProtKB:Q9UMF0	Human	PMID:32814053
Cellular Component	GO:0005829	cytosol	ALAS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	ALAS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Alas1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Alas1	IDA		Rat	PMID:17761694|RGD:2306419
Cellular Component	GO:0005654	nucleoplasm	ALAS1	IDA		Human	GO_REF:0000052
Biological Process	GO:0032869	cellular response to insulin stimulus	Alas1	IEP		Rat	PMID:11716532|RGD:4144187
Biological Process	GO:0071407	cellular response to organic cyclic compound	Alas1	IEP		Rat	PMID:11368315|RGD:4144191
Biological Process	GO:0030223	neutrophil differentiation	alas1	IMP	ZFIN:ZDB-GENO-140124-30	Zfish	PMID:29954941
Biological Process	GO:1903412	response to bile acid	ALAS1	IDA		Human	PMID:17975826
Biological Process	GO:0051591	response to cAMP	Alas1	IEP		Rat	PMID:17761694|RGD:2306419
Biological Process	GO:0032025	response to cobalt ion	Alas1	IEP		Rat	PMID:6688350|RGD:4144808
Biological Process	GO:0032025	response to cobalt ion	Alas1	IEP		Rat	PMID:818637|RGD:4144807
Biological Process	GO:0045471	response to ethanol	Alas1	IEP		Rat	PMID:18472004|RGD:2306418
Biological Process	GO:0034698	response to gonadotropin	Alas1	IEP		Rat	PMID:19467246|RGD:4144147
Biological Process	GO:0009635	response to herbicide	Alas1	IEP		Rat	PMID:12180188|RGD:4144184
Biological Process	GO:0001666	response to hypoxia	Alas1	IEP		Rat	PMID:9849899|RGD:2306420
Biological Process	GO:0010045	response to nickel cation	Alas1	IEP		Rat	PMID:925603|RGD:4144822
Biological Process	GO:0031667	response to nutrient levels	Alas1	IEP		Rat	PMID:17537461|RGD:4144166
Biological Process	GO:0014070	response to organic cyclic compound	Alas1	IEP		Rat	PMID:18657588|RGD:2306417
Biological Process	GO:0010033	response to organic substance	Alas1	IEP		Rat	PMID:17761694|RGD:2306419
Biological Process	GO:0070541	response to platinum ion	Alas1	IEP		Rat	PMID:925603|RGD:4144822
Biological Process	GO:0009410	response to xenobiotic stimulus	Alas1	IEP		Rat	PMID:818637|RGD:4144807

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern