Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALDH1A1
  • Mouse genes Aldh1a1
  • Rat genes Aldh1a1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aldh1a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	Aldh1a1	IDA		Mouse	PMID:12610736
Molecular Function	GO:0106373	3-deoxyglucosone dehydrogenase activity	ALDH1A1	IDA		Human	PMID:17175089
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH1A1	IDA		Human	PMID:12941160
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH1A1	IMP		Human	PMID:15623782
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH1A1	IDA		Human	PMID:23444097
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH1A1	IDA		Human	PMID:25450233
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH1A1	IDA		Human	PMID:4015840
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	Aldh1a1	IDA		Rat	PMID:10998257|RGD:2306339
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	Aldh1a1	IMP		Rat	PMID:15623782|RGD:2306321
Molecular Function	GO:0019145	aminobutyraldehyde dehydrogenase activity	Aldh1a1	IMP		Mouse	MGI:MGI:5697738|PMID:26430123
Molecular Function	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity	Aldh1a1	IDA		Rat	PMID:10998257|RGD:2306339
Molecular Function	GO:0042802	identical protein binding	Aldh1a1	IPI	RGD:2087	Rat	PMID:10998257|RGD:2306339
Molecular Function	GO:0005515	protein binding	ALDH1A1	IPI	UniProtKB:P09172	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALDH1A1	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALDH1A1	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ALDH1A1	IPI	UniProtKB:O60678	Human	PMID:33495566
Molecular Function	GO:0001758	retinal dehydrogenase activity	Aldh1a1	IDA		Rat	PMID:17167544|RGD:2306320
Molecular Function	GO:0001758	retinal dehydrogenase activity	Aldh1a1	IDA		Rat	PMID:7832787|RGD:11558002
Cellular Component	GO:0030424	axon	Aldh1a1	IDA		Mouse	MGI:MGI:5697738|PMID:26430123
Cellular Component	GO:0005737	cytoplasm	Aldh1a1	IDA		Rat	PMID:21138835|RGD:6771354
Cellular Component	GO:0005829	cytosol	ALDH1A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ALDH1A1	IDA		Human	PMID:12941160
Cellular Component	GO:0070062	extracellular exosome	ALDH1A1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ALDH1A1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ALDH1A1	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	Aldh1a1	IDA		Rat	PMID:21138835|RGD:6771354
Cellular Component	GO:0045202	synapse	Aldh1a1	IDA		Mouse	MGI:MGI:5697738|PMID:26430123
Biological Process	GO:0042904	9-cis-retinoic acid biosynthetic process	Aldh1a1	IDA		Mouse	PMID:11876656
Biological Process	GO:0042905	9-cis-retinoic acid metabolic process	Aldh1a1	IDA		Rat	PMID:17167544|RGD:2306320
Biological Process	GO:0006915	apoptotic process	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16207763
Biological Process	GO:0006915	apoptotic process	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16611695
Biological Process	GO:0110095	cellular detoxification of aldehyde	ALDH1A1	IMP		Human	PMID:15623782
Biological Process	GO:0110095	cellular detoxification of aldehyde	Aldh1a1	IMP		Rat	PMID:15623782|RGD:2306321
Biological Process	GO:0048048	embryonic eye morphogenesis	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16611695
Biological Process	GO:0048048	embryonic eye morphogenesis	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16207763
Biological Process	GO:0044849	estrous cycle	Aldh1a1	IEP		Rat	PMID:18202528|RGD:2306318
Biological Process	GO:0030392	fructosamine catabolic process	ALDH1A1	IDA		Human	PMID:17175089
Biological Process	GO:0006001	fructose catabolic process	Aldh1a1	IDA		Mouse	PMID:29414685
Biological Process	GO:0006001	fructose catabolic process	Aldh1a1	IDA		Mouse	PMID:4343087
Biological Process	GO:0009449	gamma-aminobutyric acid biosynthetic process	Aldh1a1	IMP		Mouse	MGI:MGI:5697738|PMID:26430123
Biological Process	GO:0001822	kidney development	Aldh1a1	IEP		Rat	PMID:15567713|RGD:2306322
Biological Process	GO:0001889	liver development	Aldh1a1	IEP		Rat	PMID:14729401|RGD:1643117
Biological Process	GO:0036438	maintenance of lens transparency	Aldh1a1	IMP		Rat	PMID:15623782|RGD:2306321
Biological Process	GO:0007494	midgut development	Aldh1a1	IEP		Rat	PMID:15964596|RGD:1643113
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Aldh1a1	IMP		Mouse	MGI:MGI:5437393|PMID:22561685
Biological Process	GO:0002072	optic cup morphogenesis involved in camera-type eye development	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16611695
Biological Process	GO:0043065	positive regulation of apoptotic process	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16611695
Biological Process	GO:0043065	positive regulation of apoptotic process	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16207763
Biological Process	GO:0032355	response to estradiol	Aldh1a1	IEP		Rat	PMID:18202528|RGD:2306318
Biological Process	GO:0045471	response to ethanol	Aldh1a1	IDA		Rat	PMID:17673211|RGD:2306319
Biological Process	GO:0014070	response to organic cyclic compound	Aldh1a1	IEP		Rat	PMID:18807137|RGD:2306317
Biological Process	GO:0006979	response to oxidative stress	Aldh1a1	IMP		Rat	PMID:15623782|RGD:2306321
Biological Process	GO:0032526	response to retinoic acid	Aldh1a1	IEP		Rat	PMID:11169459|RGD:2306337
Biological Process	GO:0009410	response to xenobiotic stimulus	Aldh1a1	IDA		Mouse	PMID:18971422
Biological Process	GO:0009410	response to xenobiotic stimulus	Aldh1a1	IEP		Rat	PMID:10323328|RGD:2306338
Biological Process	GO:0002138	retinoic acid biosynthetic process	Aldh1a1	IMP		Rat	PMID:21138835|RGD:6771354
Biological Process	GO:0042573	retinoic acid metabolic process	Aldh1a1	IGI	MGI:MGI:1861722	Mouse	PMID:16207763
Biological Process	GO:0042573	retinoic acid metabolic process	Aldh1a1	IMP	MGI:MGI:2667220	Mouse	PMID:12808103
Biological Process	GO:0042573	retinoic acid metabolic process	Aldh1a1	IMP	MGI:MGI:2667220	Mouse	PMID:12851412
Biological Process	GO:0042573	retinoic acid metabolic process	Aldh1a1	IDA		Mouse	PMID:10191271
Biological Process	GO:0042573	retinoic acid metabolic process	Aldh1a1	IMP	MGI:MGI:3609477	Mouse	PMID:16207763
Biological Process	GO:0001523	retinoid metabolic process	Aldh1a1	IDA		Rat	PMID:7832787|RGD:11558002
Biological Process	GO:0042572	retinol metabolic process	Aldh1a1	IMP	MGI:MGI:2667220	Mouse	PMID:12851412

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern