Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALDH2
  • Mouse genes Aldh2
  • Rat genes Aldh2
  • Zfish genes aldh2.1,aldh2.2,wu:fb14d09
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aldh2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	aldh2.1	IDA		Zfish	PMID:15703303
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH2	IDA		Human	PMID:19506075
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH2	IDA		Human	PMID:20062057
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH2	IDA		Human	PMID:27521998
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ALDH2	IDA		Human	PMID:4015840
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	Aldh2	IMP		Rat	PMID:18787169|RGD:7241592
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	Aldh2	IDA		Rat	PMID:4149764|RGD:2306411
Molecular Function	GO:0106435	carboxylesterase activity	ALDH2	IDA		Human	PMID:19506075
Molecular Function	GO:0042802	identical protein binding	Aldh2	IDA		Rat	PMID:1898068|RGD:2306412
Molecular Function	GO:0070404	NADH binding	Aldh2	IDA		Rat	PMID:21276780|RGD:7241587
Molecular Function	GO:0018547	nitroglycerin reductase activity	ALDH2	IDA		Human	PMID:19506075
Molecular Function	GO:0005515	protein binding	Aldh2	IPI	UniProtKB:Q8R104	Mouse	MGI:MGI:5141159|PMID:21720390
Molecular Function	GO:0005515	protein binding	Aldh2	IPI	UniProtKB:Q02776	Rat	PMID:23403928|RGD:10047228
Cellular Component	GO:0070062	extracellular exosome	ALDH2	HDA		Human	PMID:19056867
Cellular Component	GO:0005759	mitochondrial matrix	Aldh2	IDA		Rat	PMID:29491208|RGD:15036803
Cellular Component	GO:0005739	mitochondrion	Aldh2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Aldh2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Aldh2	IDA		Rat	PMID:11535626|RGD:15036815
Cellular Component	GO:0005739	mitochondrion	Aldh2	IDA		Rat	PMID:1898068|RGD:2306412
Biological Process	GO:0006117	acetaldehyde metabolic process	Aldh2	IMP		Rat	PMID:11535626|RGD:15036815
Biological Process	GO:0046185	aldehyde catabolic process	ALDH2	IDA		Human	PMID:20062057
Biological Process	GO:0046185	aldehyde catabolic process	ALDH2	IDA		Human	PMID:27521998
Biological Process	GO:0008637	apoptotic mitochondrial changes	Aldh2	IEP		Rat	PMID:30131474|RGD:15036798
Biological Process	GO:0048149	behavioral response to ethanol	Aldh2	IMP		Rat	PMID:11535626|RGD:15036815
Biological Process	GO:0110095	cellular detoxification of aldehyde	Aldh2	IMP		Rat	PMID:29589772|RGD:14975297
Biological Process	GO:0071398	cellular response to fatty acid	Aldh2	IEP		Rat	PMID:11463352|RGD:2306342
Biological Process	GO:0032870	cellular response to hormone stimulus	Aldh2	IEP		Rat	PMID:8749803|RGD:2306410
Biological Process	GO:1904639	cellular response to resveratrol	Aldh2	IEP		Rat	PMID:28688179|RGD:14981582
Biological Process	GO:0006067	ethanol metabolic process	Aldh2	IEP		Rat	PMID:28688179|RGD:14981582
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Aldh2	IMP		Rat	PMID:29589772|RGD:14975297
Biological Process	GO:0001889	liver development	Aldh2	IEP		Rat	PMID:16291827|RGD:2300311
Biological Process	GO:0043066	negative regulation of apoptotic process	Aldh2	IMP		Rat	PMID:21123025|RGD:7241589
Biological Process	GO:2001038	regulation of cellular response to drug	aldh2.2	IMP	ZFIN:ZDB-MRPHLNO-120822-1	Zfish	PMID:22840776
Biological Process	GO:1903179	regulation of dopamine biosynthetic process	Aldh2	IMP		Mouse	MGI:MGI:6827320|PMID:26711020
Biological Process	GO:0050727	regulation of inflammatory response	Aldh2	IMP		Rat	PMID:29589772|RGD:14975297
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	Aldh2	IMP		Rat	PMID:29589772|RGD:14975297
Biological Process	GO:1902882	regulation of response to oxidative stress	Aldh2	IEP		Rat	PMID:30131474|RGD:15036798
Biological Process	GO:1905627	regulation of serotonin biosynthetic process	Aldh2	IMP		Mouse	MGI:MGI:6827320|PMID:26711020
Biological Process	GO:0032355	response to estradiol	Aldh2	IEP		Rat	PMID:16339744|RGD:1599058
Biological Process	GO:0045471	response to ethanol	Aldh2	IEP		Rat	PMID:28688179|RGD:14981582
Biological Process	GO:0009408	response to heat	Aldh2	IEP		Rat	PMID:17607160|RGD:15036802
Biological Process	GO:0055093	response to hyperoxia	Aldh2	IEP		Rat	PMID:16782756|RGD:2306340
Biological Process	GO:0002931	response to ischemia	Aldh2	IEP		Rat	PMID:30131474|RGD:15036798
Biological Process	GO:0032496	response to lipopolysaccharide	Aldh2	IEP		Rat	PMID:11578593|RGD:1599044
Biological Process	GO:0035094	response to nicotine	Aldh2	IEP		Rat	PMID:12359213|RGD:1599043
Biological Process	GO:0014070	response to organic cyclic compound	Aldh2	IMP		Rat	PMID:29589772|RGD:14975297
Biological Process	GO:0032570	response to progesterone	Aldh2	IEP		Rat	PMID:8749803|RGD:2306410
Biological Process	GO:0033574	response to testosterone	Aldh2	IEP		Rat	PMID:8749803|RGD:2306410

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern