Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALKAL2
  • Mouse genes Alkal2
  • Rat genes Alkal2
  • Zfish genes alkal2a,alkal2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alkal2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	ALKAL2	IDA		Human	PMID:30061385
Molecular Function	GO:0005125	cytokine activity	ALKAL2	IDA		Human	PMID:34646012
Molecular Function	GO:0005125	cytokine activity	ALKAL2	IDA		Human	PMID:34819673
Molecular Function	GO:0005125	cytokine activity	alkal2b	IDA		Zfish	PMID:29078341|ZFIN:ZDB-PUB-171029-7
Molecular Function	GO:0005125	cytokine activity	alkal2a	IDA		Zfish	PMID:29078341|ZFIN:ZDB-PUB-171029-7
Molecular Function	GO:0005125	cytokine activity	alkal2a	IDA		Zfish	PMID:29317532|ZFIN:ZDB-PUB-180111-6
Molecular Function	GO:0005125	cytokine activity	alkal2b	IDA		Zfish	PMID:29317532|ZFIN:ZDB-PUB-180111-6
Molecular Function	GO:0005515	protein binding	ALKAL2	IPI	UniProtKB:Q9UM73	Human	PMID:26418745
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:26418745
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:30061385
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:34646012
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:34819673
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	alkal2a	IDA		Zfish	PMID:29078341|ZFIN:ZDB-PUB-171029-7
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	alkal2a	IDA		Zfish	PMID:29317532|ZFIN:ZDB-PUB-180111-6
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	alkal2b	IDA		Zfish	PMID:29317532|ZFIN:ZDB-PUB-180111-6
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	alkal2b	IDA		Zfish	PMID:29078341|ZFIN:ZDB-PUB-171029-7
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ALKAL2	IDA		Human	PMID:26418745
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:30061385
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:34646012
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	ALKAL2	IDA		Human	PMID:34819673
Cellular Component	GO:0005576	extracellular region	ALKAL2	IDA		Human	PMID:30061385
Cellular Component	GO:0005615	extracellular space	ALKAL2	IDA		Human	PMID:30061385
Biological Process	GO:0050935	iridophore differentiation	alkal2a	IMP	ZFIN:ZDB-GENO-181213-20	Zfish	PMID:29317532
Biological Process	GO:0050935	iridophore differentiation	alkal2a	IMP	ZFIN:ZDB-GENO-190312-6	Zfish	PMID:29078341
Biological Process	GO:0050935	iridophore differentiation	alkal2b	IMP	ZFIN:ZDB-GENO-190312-7	Zfish	PMID:29078341
Biological Process	GO:0050935	iridophore differentiation	alkal2b	IMP	ZFIN:ZDB-GENO-181213-21	Zfish	PMID:29317532
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ALKAL2	IDA		Human	PMID:26418745
Biological Process	GO:0070378	positive regulation of ERK5 cascade	ALKAL2	IDA		Human	PMID:26418745
Biological Process	GO:0010976	positive regulation of neuron projection development	ALKAL2	IDA		Human	PMID:26418745
Biological Process	GO:0010976	positive regulation of neuron projection development	ALKAL2	IDA		Human	PMID:30061385
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALKAL2	IDA		Human	PMID:30061385
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALKAL2	IDA		Human	PMID:34646012
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ALKAL2	IDA		Human	PMID:34819673

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern