Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALOX15
  • Mouse genes Alox15
  • Rat genes Alox15
  • Zfish genes alox12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX15	IDA		Human	PMID:1944593
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox15	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox15	IDA		Rat	PMID:8117750|RGD:70288
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IDA		Zfish	PMID:21880725
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IMP	ZFIN:ZDB-MRPHLNO-120130-4	Zfish	PMID:22143766
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IMP	ZFIN:ZDB-MRPHLNO-120130-3	Zfish	PMID:22143766
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IDA		Zfish	PMID:22143766
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15	IDA		Human	PMID:17052953
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15	IDA		Human	PMID:1944593
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15	IDA		Human	PMID:24282679
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15	IDA		Human	PMID:8334154
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	Alox15	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	Alox15	IDA		Rat	PMID:8444196|RGD:70287
Molecular Function	GO:0005509	calcium ion binding	alox12	IDA		Zfish	PMID:28528958
Molecular Function	GO:0051120	hepoxilin A3 synthase activity	Alox15	IDA		Rat	PMID:15123652|RGD:5509794
Molecular Function	GO:0047977	hepoxilin-epoxide hydrolase activity	Alox15	IDA		Rat	PMID:15123652|RGD:5509794
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ALOX15	IDA		Human	PMID:8334154
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	alox12	IDA		Zfish	PMID:28528958
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ALOX15	IDA		Human	PMID:17052953
Molecular Function	GO:0005515	protein binding	ALOX15	IPI	UniProtKB:P30086	Human	PMID:21831839
Cellular Component	GO:0005737	cytoplasm	Alox15	IDA		Mouse	PMID:17426145
Cellular Component	GO:0005829	cytosol	ALOX15	IDA		Human	PMID:17052953
Cellular Component	GO:0005829	cytosol	ALOX15	IDA		Human	PMID:21831839
Cellular Component	GO:0005829	cytosol	Alox15	IDA		Mouse	MGI:MGI:5508294|PMID:11278875
Cellular Component	GO:0005829	cytosol	Alox15	IDA		Rat	PMID:15123652|RGD:5509794
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ALOX15	IDA		Human	PMID:17052953
Cellular Component	GO:0005811	lipid droplet	ALOX15	IDA		Human	PMID:19528634
Cellular Component	GO:0016020	membrane	ALOX15	IDA		Human	PMID:21831839
Cellular Component	GO:0005634	nucleus	alox12	IDA		Zfish	PMID:22143766
Cellular Component	GO:0005886	plasma membrane	Alox15	IDA		Mouse	MGI:MGI:5508294|PMID:11278875
Biological Process	GO:0043277	apoptotic cell clearance	Alox15	IMP		Mouse	MGI:MGI:5436199|PMID:22503541
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15	IDA		Human	PMID:17052953
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15	IDA		Human	PMID:1944593
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15	IDA		Human	PMID:24282679
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15	IDA		Human	PMID:8334154
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox15	IMP		Mouse	MGI:MGI:1101294|PMID:8798642
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox15	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox15	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox15	IDA		Rat	PMID:8117750|RGD:70288
Biological Process	GO:0030282	bone mineralization	Alox15	IMP	MGI:MGI:1857428	Mouse	PMID:14716014
Biological Process	GO:0071277	cellular response to calcium ion	ALOX15	IDA		Human	PMID:17052953
Biological Process	GO:0035963	cellular response to interleukin-13	ALOX15	IMP		Human	PMID:21831839
Biological Process	GO:0051122	hepoxilin biosynthetic process	Alox15	IDA		Rat	PMID:15123652|RGD:5509794
Biological Process	GO:0051122	hepoxilin biosynthetic process	Alox15	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0043651	linoleic acid metabolic process	ALOX15	IDA		Human	PMID:8334154
Biological Process	GO:0006629	lipid metabolic process	ALOX15	IDA		Human	PMID:23242647
Biological Process	GO:0006629	lipid metabolic process	ALOX15	IDA		Human	PMID:25293588
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	Alox15	IMP		Mouse	MGI:MGI:3579746|PMID:15708862
Biological Process	GO:0019372	lipoxygenase pathway	ALOX15	IDA		Human	PMID:1944593
Biological Process	GO:0019372	lipoxygenase pathway	ALOX15	IDA		Human	PMID:23242647
Biological Process	GO:0019372	lipoxygenase pathway	Alox15	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Biological Process	GO:0019372	lipoxygenase pathway	Alox15	IMP		Mouse	MGI:MGI:1101294|PMID:8798642
Biological Process	GO:0019372	lipoxygenase pathway	Alox15	IDA		Rat	PMID:8117750|RGD:70288
Biological Process	GO:0002820	negative regulation of adaptive immune response	Alox15	IMP		Mouse	MGI:MGI:5436199|PMID:22503541
Biological Process	GO:0001503	ossification	Alox15	IMP	MGI:MGI:1857428	Mouse	PMID:14716014
Biological Process	GO:0006646	phosphatidylethanolamine biosynthetic process	Alox15	IMP		Mouse	MGI:MGI:5436199|PMID:22503541
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Alox15	IMP		Mouse	MGI:MGI:5508294|PMID:11278875
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	ALOX15	IDA		Human	PMID:11278875
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ALOX15	IMP		Human	PMID:21831839
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	Alox15	IMP		Rat	PMID:15576842|RGD:5509796
Biological Process	GO:1901074	regulation of engulfment of apoptotic cell	Alox15	IMP		Mouse	MGI:MGI:5436199|PMID:22503541
Biological Process	GO:1901074	regulation of engulfment of apoptotic cell	Alox15	IMP		Mouse	MGI:MGI:5508294|PMID:11278875
Biological Process	GO:0050727	regulation of inflammatory response	ALOX15	IDA		Human	PMID:23242647
Biological Process	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	Alox15	IMP		Mouse	MGI:MGI:5508298|PMID:10432118
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Alox15	IMP		Mouse	MGI:MGI:5425208|PMID:22215650
Biological Process	GO:0042060	wound healing	Alox15	IMP		Mouse	MGI:MGI:3579746|PMID:15708862

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern