Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALOX5AP
  • Mouse genes Alox5ap
  • Rat genes Alox5ap
  • Zfish genes alox5ap
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox5ap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	Alox5ap	IDA		Rat	PMID:2300173|RGD:69749
Molecular Function	GO:0050544	arachidonic acid binding	ALOX5AP	IDA		Human	PMID:8440384
Molecular Function	GO:0019899	enzyme binding	Alox5ap	IPI	RGD:2096	Rat	PMID:19075240|RGD:2313889
Molecular Function	GO:0042802	identical protein binding	Alox5ap	IPI	RGD:2097	Rat	PMID:15084748|RGD:2313918
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:P09917	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:Q16873	Human	PMID:19233132
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:A0PK00	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:P35372-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:Q96FB2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX5AP	IPI	UniProtKB:Q9H115	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Alox5ap	IPI	PR:P48999	Mouse	PMID:19075240
Molecular Function	GO:0044877	protein-containing complex binding	Alox5ap	IPI	RGD:620677	Rat	PMID:15084748|RGD:2313918
Cellular Component	GO:0005829	cytosol	Alox5ap	IDA		Rat	PMID:8071328|RGD:5147470
Cellular Component	GO:0005783	endoplasmic reticulum	ALOX5AP	IDA		Human	PMID:19233132
Cellular Component	GO:0005783	endoplasmic reticulum	Alox5ap	IDA		Rat	PMID:8071328|RGD:5147470
Cellular Component	GO:0016020	membrane	ALOX5AP	HDA		Human	PMID:19946888
Cellular Component	GO:0005635	nuclear envelope	ALOX5AP	IDA		Human	PMID:19233132
Cellular Component	GO:0005635	nuclear envelope	Alox5ap	IDA		Rat	PMID:19075240|RGD:2313889
Cellular Component	GO:0031965	nuclear membrane	ALOX5AP	IDA		Human	PMID:8245774
Cellular Component	GO:0005634	nucleus	Alox5ap	IDA		Mouse	PMID:19075240
Biological Process	GO:0001525	angiogenesis	alox5ap	IMP	ZFIN:ZDB-MRPHLNO-091216-9	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	alox5ap	IMP	ZFIN:ZDB-MRPHLNO-091216-8	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	alox5ap	IMP	ZFIN:ZDB-MRPHLNO-091216-8,ZFIN:ZDB-MRPHLNO-091216-9	Zfish	PMID:19389629
Biological Process	GO:0071277	cellular response to calcium ion	ALOX5AP	IDA		Human	PMID:2300173
Biological Process	GO:0019370	leukotriene biosynthetic process	ALOX5AP	IDA		Human	PMID:2300173
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5ap	IMP	MGI:MGI:2156546	Mouse	PMID:9091580
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5ap	IDA		Mouse	PMID:19075240
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5ap	IDA		Rat	PMID:19075240|RGD:2313889
Biological Process	GO:0019370	leukotriene biosynthetic process	Alox5ap	IDA		Rat	PMID:2300173|RGD:69749
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	Alox5ap	IMP	MGI:MGI:2156546	Mouse	PMID:9091580
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	Alox5ap	IMP	MGI:MGI:2156546	Mouse	PMID:10779800
Biological Process	GO:0019372	lipoxygenase pathway	Alox5ap	IDA		Rat	PMID:17517102|RGD:2313910
Biological Process	GO:0019372	lipoxygenase pathway	Alox5ap	IMP		Rat	PMID:18945963|RGD:2313900
Biological Process	GO:0002675	positive regulation of acute inflammatory response	Alox5ap	IMP		Rat	PMID:20519143|RGD:5147468
Biological Process	GO:0070207	protein homotrimerization	ALOX5AP	IPI	UniProtKB:P20292	Human	PMID:17600184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern