Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALOX15B
  • Mouse genes Alox8
  • Rat genes Alox15b
  • Zfish genes si:dkey-17e16.9,zgc:152891
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:10542053
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:10625675
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:11956198
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:17493578
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:18311922
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:24282679
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:24497644
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:27145229
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:27435673
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX15B	IDA		Human	PMID:9177185
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:5810233|PMID:27435673
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	Alox15b	IDA		Rat	PMID:23382512|RGD:8554649
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:6414723|PMID:16112079
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:3784332|PMID:10965849
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:5508744|PMID:10625675
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:1097306|PMID:9305900
Molecular Function	GO:0005509	calcium ion binding	ALOX15B	IDA		Human	PMID:24497644
Molecular Function	GO:0005506	iron ion binding	ALOX15B	IDA		Human	PMID:24497644
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ALOX15B	IDA		Human	PMID:10542053
Molecular Function	GO:1990136	linoleate 9S-lipoxygenase activity	Alox8	IDA		Mouse	MGI:MGI:1097306|PMID:9305900
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:P10276	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:P19474	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:P78358	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:Q96NT0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:Q9BWF2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ALOX15B	IPI	UniProtKB:Q9H3M0	Human	PMID:32296183
Cellular Component	GO:0005912	adherens junction	ALOX15B	IDA		Human	PMID:12704195
Cellular Component	GO:0005856	cytoskeleton	ALOX15B	IDA		Human	PMID:12704195
Cellular Component	GO:0005829	cytosol	ALOX15B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ALOX15B	IDA		Human	PMID:10542053
Cellular Component	GO:0005829	cytosol	ALOX15B	IDA		Human	PMID:12704195
Cellular Component	GO:0070062	extracellular exosome	ALOX15B	HDA		Human	PMID:23533145
Cellular Component	GO:0019898	extrinsic component of membrane	ALOX15B	IDA		Human	PMID:24497644
Cellular Component	GO:0005925	focal adhesion	ALOX15B	IDA		Human	PMID:12704195
Cellular Component	GO:0016020	membrane	ALOX15B	IDA		Human	PMID:10542053
Cellular Component	GO:0005886	plasma membrane	ALOX15B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ALOX15B	IDA		Human	PMID:12704195
Cellular Component	GO:0005886	plasma membrane	ALOX15B	IDA		Human	PMID:27435673
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:10542053
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:10625675
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:24282679
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:24497644
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:27145229
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX15B	IDA		Human	PMID:9177185
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox8	IDA		Mouse	MGI:MGI:1097306|PMID:9305900
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox15b	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:1901696	cannabinoid biosynthetic process	ALOX15B	IDA		Human	PMID:11956198
Biological Process	GO:0071926	endocannabinoid signaling pathway	ALOX15B	IDA		Human	PMID:11956198
Biological Process	GO:0051122	hepoxilin biosynthetic process	Alox15b	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0043651	linoleic acid metabolic process	Alox8	IDA		Mouse	MGI:MGI:1097306|PMID:9305900
Biological Process	GO:0006629	lipid metabolic process	ALOX15B	IDA		Human	PMID:17493578
Biological Process	GO:0006629	lipid metabolic process	ALOX15B	IDA		Human	PMID:18311922
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	ALOX15B	IDA		Human	PMID:27145229
Biological Process	GO:0019372	lipoxygenase pathway	Alox8	IDA		Mouse	MGI:MGI:1097306|PMID:9305900
Biological Process	GO:0019372	lipoxygenase pathway	Alox15b	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0045786	negative regulation of cell cycle	ALOX15B	IDA		Human	PMID:11839751
Biological Process	GO:0008285	negative regulation of cell population proliferation	ALOX15B	IDA		Human	PMID:11839751
Biological Process	GO:0008285	negative regulation of cell population proliferation	ALOX15B	IMP		Human	PMID:12704195
Biological Process	GO:0045926	negative regulation of growth	ALOX15B	IDA		Human	PMID:11839751
Biological Process	GO:0006644	phospholipid metabolic process	ALOX15B	IDA		Human	PMID:27435673
Biological Process	GO:0006644	phospholipid metabolic process	Alox8	IDA		Mouse	MGI:MGI:5810233|PMID:27435673
Biological Process	GO:0032722	positive regulation of chemokine production	ALOX15B	IMP		Human	PMID:18067895
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	Alox8	IMP		Mouse	MGI:MGI:3784332|PMID:10965849
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ALOX15B	IMP		Human	PMID:22912809
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	Alox8	IMP		Mouse	MGI:MGI:3784332|PMID:10965849

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern