Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALPL
  • Mouse genes Alpl
  • Rat genes Alpl
  • Zfish genes alpl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alpl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004035	alkaline phosphatase activity	ALPL	IDA		Human	PMID:12162492
Molecular Function	GO:0004035	alkaline phosphatase activity	ALPL	IDA		Human	PMID:33821301
Molecular Function	GO:0004035	alkaline phosphatase activity	Alpl	IDA		Mouse	PMID:10787428
Molecular Function	GO:0004035	alkaline phosphatase activity	Alpl	IDA		Mouse	PMID:7533563
Molecular Function	GO:0004035	alkaline phosphatase activity	Alpl	IDA		Mouse	PMID:18031938
Molecular Function	GO:0004035	alkaline phosphatase activity	Alpl	IDA		Rat	PMID:3472490|RGD:1599079
Molecular Function	GO:0005509	calcium ion binding	ALPL	IDA		Human	PMID:11395499
Molecular Function	GO:0050187	phosphoamidase activity	Alpl	IDA		Mouse	PMID:33981039
Molecular Function	GO:0052732	phosphoethanolamine phosphatase activity	ALPL	IDA		Human	PMID:2220817
Molecular Function	GO:0005515	protein binding	ALPL	IPI	UniProtKB:Q99558	Human	PMID:15208311
Molecular Function	GO:0005515	protein binding	Alpl	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0033883	pyridoxal phosphatase activity	ALPL	IDA		Human	PMID:12162492
Molecular Function	GO:0033883	pyridoxal phosphatase activity	ALPL	IDA		Human	PMID:2220817
Molecular Function	GO:0016462	pyrophosphatase activity	ALPL	IDA		Human	PMID:12162492
Molecular Function	GO:0016462	pyrophosphatase activity	ALPL	IDA		Human	PMID:19874193
Molecular Function	GO:0016462	pyrophosphatase activity	Alpl	IDA		Mouse	MGI:MGI:6810799|PMID:29174347
Molecular Function	GO:0016462	pyrophosphatase activity	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:19874193
Cellular Component	GO:0070062	extracellular exosome	ALPL	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ALPL	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	Alpl	IDA		Mouse	PMID:19874193
Cellular Component	GO:0065010	extracellular membrane-bounded organelle	Alpl	IDA		Mouse	PMID:19874193
Cellular Component	GO:0065010	extracellular membrane-bounded organelle	Alpl	IDA		Rat	PMID:32710882|RGD:127285402
Cellular Component	GO:0005615	extracellular space	Alpl	IDA		Rat	PMID:19697513|RGD:2315618
Cellular Component	GO:0016020	membrane	ALPL	HDA		Human	PMID:16210410
Cellular Component	GO:0005758	mitochondrial intermembrane space	Alpl	IDA		Mouse	MGI:MGI:6716981|PMID:33981039
Cellular Component	GO:0031966	mitochondrial membrane	Alpl	IDA		Mouse	PMID:33981039
Cellular Component	GO:0005886	plasma membrane	ALPL	IDA		Human	PMID:2220817
Cellular Component	GO:0005886	plasma membrane	ALPL	IDA		Human	PMID:33821301
Cellular Component	GO:0005886	plasma membrane	Alpl	IDA		Mouse	PMID:7533563
Cellular Component	GO:0005886	plasma membrane	Alpl	IDA		Mouse	PMID:10787428
Cellular Component	GO:0005886	plasma membrane	Alpl	IDA		Rat	PMID:19697513|RGD:2315618
Biological Process	GO:0031214	biomineral tissue development	alpl	IMP	ZFIN:ZDB-MRPHLNO-210310-2	Zfish	PMID:32770041
Biological Process	GO:0031214	biomineral tissue development	alpl	IMP	ZFIN:ZDB-MRPHLNO-210310-1	Zfish	PMID:32770041
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:6827471|PMID:11028439
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:2183534|PMID:10620060
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:6827210|PMID:26457330
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:86401|PMID:9056646
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:5049900|PMID:20684022
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	MGI:MGI:3033280|PMID:14982838
Biological Process	GO:0030282	bone mineralization	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:15920156
Biological Process	GO:0030282	bone mineralization	Alpl	IMP		Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:15920156
Biological Process	GO:0030282	bone mineralization	Alpl	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	alpl	IMP	ZFIN:ZDB-MRPHLNO-210310-2	Zfish	PMID:32770041
Biological Process	GO:0030282	bone mineralization	alpl	IMP	ZFIN:ZDB-MRPHLNO-210310-1	Zfish	PMID:32770041
Biological Process	GO:0055074	calcium ion homeostasis	ALPL	IDA		Human	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Alpl	IDA		Mouse	PMID:21490328
Biological Process	GO:0055074	calcium ion homeostasis	Alpl	IMP		Mouse	PMID:28592560
Biological Process	GO:0019725	cellular homeostasis	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Alpl	IMP		Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Alpl	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0071407	cellular response to organic cyclic compound	Alpl	IDA		Mouse	PMID:15728361
Biological Process	GO:0071529	cementum mineralization	Alpl	IEP		Rat	PMID:17043865|RGD:2316162
Biological Process	GO:0003006	developmental process involved in reproduction	Alpl	IGI	MGI:MGI:1354733	Mouse	PMID:17540358
Biological Process	GO:0001958	endochondral ossification	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:20684022
Biological Process	GO:0140651	futile creatine cycle	Alpl	IDA		Mouse	PMID:33981039
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Alpl	IMP	MGI:MGI:1856651	Mouse	PMID:21490328
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Alpl	IMP	MGI:MGI:2385534	Mouse	PMID:21490328
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Alpl	IDA		Mouse	PMID:21490328
Biological Process	GO:0001649	osteoblast differentiation	ALPL	HDA		Human	PMID:16210410
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IMP		Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IDA		Mouse	PMID:21490328
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IMP		Mouse	PMID:21490328
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Alpl	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Alpl	IDA		Mouse	MGI:MGI:6716981|PMID:33981039
Biological Process	GO:0042822	pyridoxal phosphate metabolic process	Alpl	IDA		Mouse	MGI:MGI:76012|PMID:7550313
Biological Process	GO:0046677	response to antibiotic	Alpl	IDA		Mouse	PMID:2133555
Biological Process	GO:0051384	response to glucocorticoid	Alpl	IDA		Rat	PMID:2039500|RGD:1599078
Biological Process	GO:0032868	response to insulin	Alpl	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0032496	response to lipopolysaccharide	Alpl	IEP		Rat	PMID:11810315|RGD:2315621
Biological Process	GO:0036005	response to macrophage colony-stimulating factor	Alpl	IEP		Rat	PMID:7669437|RGD:151665777
Biological Process	GO:0009612	response to mechanical stimulus	alpl	IDA		Zfish	PMID:23632157
Biological Process	GO:0014070	response to organic cyclic compound	Alpl	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:1904383	response to sodium phosphate	Alpl	IDA		Mouse	PMID:23523568
Biological Process	GO:1904383	response to sodium phosphate	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:1904383	response to sodium phosphate	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0034516	response to vitamin B6	Alpl	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0034516	response to vitamin B6	Alpl	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0033280	response to vitamin D	ALPL	IEP		Human	PMID:17023519

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern