Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALS2
  • Mouse genes Als2
  • Rat genes Als2
  • Zfish genes als2a,als2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Als2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	ALS2	IDA		Human	PMID:12837691
Molecular Function	GO:0005096	GTPase activator activity	ALS2	IDA		Human	PMID:15247254
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ALS2	IDA		Human	PMID:15247254
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ALS2	IDA		Human	PMID:12837691
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ALS2	IDA		Human	PMID:16049005
Molecular Function	GO:0042802	identical protein binding	ALS2	IDA		Human	PMID:15247254
Molecular Function	GO:0005515	protein binding	ALS2	IPI	UniProtKB:P20339	Human	PMID:21300063
Molecular Function	GO:0005515	protein binding	Als2	IPI	PR:Q925T6	Mouse	PMID:17093100
Molecular Function	GO:0042803	protein homodimerization activity	ALS2	IPI	UniProtKB:Q96Q42	Human	PMID:15247254
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ALS2	IDA		Human	PMID:16049005
Molecular Function	GO:0031267	small GTPase binding	ALS2	IDA		Human	PMID:12837691
Molecular Function	GO:0031267	small GTPase binding	ALS2	IDA		Human	PMID:15247254
Cellular Component	GO:0030424	axon	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0030424	axon	Als2	IDA		Rat	PMID:16802292|RGD:1599082
Cellular Component	GO:0005813	centrosome	ALS2	IDA		Human	PMID:16085057
Cellular Component	GO:0005813	centrosome	Als2	IDA		Mouse	PMID:16085057
Cellular Component	GO:0005737	cytoplasm	Als2	IDA		Mouse	PMID:16085057
Cellular Component	GO:0005737	cytoplasm	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0005829	cytosol	ALS2	IDA		Human	PMID:12837691
Cellular Component	GO:0030425	dendrite	ALS2	IDA		Human	PMID:15371724
Cellular Component	GO:0030425	dendrite	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0030425	dendrite	Als2	IDA		Rat	PMID:16802292|RGD:1599082
Cellular Component	GO:0043197	dendritic spine	Als2	IDA		Mouse	PMID:17093100
Cellular Component	GO:0005769	early endosome	ALS2	IDA		Human	PMID:12837691
Cellular Component	GO:0030426	growth cone	Als2	IDA		Rat	PMID:16049005|RGD:1599081
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0030027	lamellipodium	Als2	IDA		Mouse	MGI:MGI:3759339|PMID:15033976
Cellular Component	GO:0016020	membrane	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0043005	neuron projection	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0043025	neuronal cell body	Als2	IDA		Rat	PMID:15033976|RGD:1599083
Cellular Component	GO:0043025	neuronal cell body	Als2	IDA		Rat	PMID:16802292|RGD:1599082
Cellular Component	GO:0005634	nucleus	ALS2	IDA		Human	PMID:12837691
Cellular Component	GO:0014069	postsynaptic density	Als2	IDA		Mouse	PMID:17093100
Cellular Component	GO:0032991	protein-containing complex	ALS2	IDA		Human	PMID:15247254
Cellular Component	GO:0001726	ruffle	Als2	IDA		Mouse	MGI:MGI:3759339|PMID:15033976
Cellular Component	GO:0031982	vesicle	ALS2	IDA		Human	PMID:12837691
Biological Process	GO:0007409	axonogenesis	Als2	IMP		Rat	PMID:16802292|RGD:1599082
Biological Process	GO:0001662	behavioral fear response	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:16107644
Biological Process	GO:0008219	cell death	Als2	IMP		Rat	PMID:16802292|RGD:1599082
Biological Process	GO:0016197	endosomal transport	Als2	IMP	MGI:MGI:3612978	Mouse	PMID:16321985
Biological Process	GO:0016197	endosomal transport	Als2	IMP	MGI:MGI:3653518	Mouse	PMID:16769894
Biological Process	GO:0001701	in utero embryonic development	Als2	IEP		Rat	PMID:16049005|RGD:1599081
Biological Process	GO:0007626	locomotory behavior	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:16107644
Biological Process	GO:0007626	locomotory behavior	Als2	IMP	MGI:MGI:3653518	Mouse	PMID:16769894
Biological Process	GO:0007041	lysosomal transport	ALS2	IDA		Human	PMID:12837691
Biological Process	GO:0007528	neuromuscular junction development	Als2	IMP	MGI:MGI:3612978	Mouse	PMID:16321985
Biological Process	GO:0048812	neuron projection morphogenesis	ALS2	IDA		Human	PMID:16049005
Biological Process	GO:0043547	positive regulation of GTPase activity	ALS2	IDA		Human	PMID:16049005
Biological Process	GO:0045860	positive regulation of protein kinase activity	ALS2	IDA		Human	PMID:16049005
Biological Process	GO:0051260	protein homooligomerization	ALS2	IDA		Human	PMID:15247254
Biological Process	GO:0008104	protein localization	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:17093100
Biological Process	GO:0016601	Rac protein signal transduction	Als2	IDA		Rat	PMID:16802292|RGD:1599082
Biological Process	GO:0001881	receptor recycling	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:17093100
Biological Process	GO:0051036	regulation of endosome size	ALS2	IEP		Human	PMID:15247254
Biological Process	GO:0043087	regulation of GTPase activity	Als2	IDA		Mouse	PMID:16085057
Biological Process	GO:0006979	response to oxidative stress	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:16107644
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Als2	IMP	MGI:MGI:3522476	Mouse	PMID:17093100
Biological Process	GO:0016050	vesicle organization	Als2	IDA		Mouse	PMID:16085057

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern