Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AMBRA1
  • Mouse genes Ambra1
  • Rat genes Ambra1
  • Zfish genes ambra1a,ambra1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ambra1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051020	GTPase binding	AMBRA1	IPI	UniProtKB:A1A4Y4	Human	PMID:25891078
Molecular Function	GO:0140678	molecular function inhibitor activity	AMBRA1	IDA		Human	PMID:33854232
Molecular Function	GO:0140678	molecular function inhibitor activity	AMBRA1	IDA		Human	PMID:33854235
Molecular Function	GO:0140678	molecular function inhibitor activity	AMBRA1	IDA		Human	PMID:33854239
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q14457	Human	PMID:20562859
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:P63167	Human	PMID:20921139
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q96FJ2	Human	PMID:20921139
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:P10415	Human	PMID:21358617
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q14457	Human	PMID:21358617
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:P12504	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:O75385	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q9Y4K3	Human	PMID:23524951
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:A8MW95	Human	PMID:23954414
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q14457	Human	PMID:23954414
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q14457	Human	PMID:23974797
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q9C035	Human	PMID:25127057
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q9GZQ8	Human	PMID:25215947
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:O75385	Human	PMID:25438055
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:P30153	Human	PMID:25438055
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q14457	Human	PMID:25438055
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q7Z6Z7	Human	PMID:30217973
Molecular Function	GO:0005515	protein binding	AMBRA1	IPI	UniProtKB:Q13049	Human	PMID:31123703
Molecular Function	GO:0005515	protein binding	Ambra1	IPI	PR:O88597	Mouse	PMID:17589504
Molecular Function	GO:0005515	protein binding	Ambra1	IPI	RGD:620190	Rat	PMID:25117440|RGD:11552604
Molecular Function	GO:0019903	protein phosphatase binding	AMBRA1	IDA		Human	PMID:25438055
Molecular Function	GO:0019903	protein phosphatase binding	AMBRA1	IDA		Human	PMID:30513302
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	AMBRA1	IDA		Human	PMID:23524951
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	AMBRA1	IDA		Human	PMID:30166453
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	AMBRA1	IDA		Human	PMID:33854232
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	AMBRA1	IDA		Human	PMID:33854235
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	AMBRA1	IDA		Human	PMID:33854239
Molecular Function	GO:0031625	ubiquitin protein ligase binding	AMBRA1	IPI	UniProtKB:O60260	Human	PMID:21753002
Cellular Component	GO:0005930	axoneme	Ambra1	IDA		Mouse	MGI:MGI:5527012|PMID:24089209
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	AMBRA1	IDA		Human	PMID:33854235
Cellular Component	GO:0005737	cytoplasm	AMBRA1	IDA		Human	PMID:21358617
Cellular Component	GO:0005737	cytoplasm	AMBRA1	IDA		Human	PMID:17589504
Cellular Component	GO:0005737	cytoplasm	Ambra1	IDA		Mouse	MGI:MGI:6810795|PMID:24980959
Cellular Component	GO:0005856	cytoskeleton	AMBRA1	IDA		Human	PMID:20921139
Cellular Component	GO:0005829	cytosol	AMBRA1	IDA		Human	PMID:21753002
Cellular Component	GO:0005829	cytosol	Ambra1	IDA		Mouse	MGI:MGI:5139926|PMID:21753002
Cellular Component	GO:0005739	mitochondrion	AMBRA1	IDA		Human	PMID:21753002
Cellular Component	GO:0005739	mitochondrion	AMBRA1	IDA		Human	PMID:21358617
Cellular Component	GO:0005739	mitochondrion	AMBRA1	IDA		Human	PMID:25215947
Cellular Component	GO:0005634	nucleus	AMBRA1	IDA		Human	PMID:32616651
Cellular Component	GO:0005634	nucleus	Ambra1	IDA		Mouse	MGI:MGI:6810795|PMID:24980959
Cellular Component	GO:0005634	nucleus	Ambra1	IDA		Mouse	MGI:MGI:6810802|PMID:32616651
Cellular Component	GO:0045335	phagocytic vesicle	Ambra1	IDA		Mouse	PMID:22493499
Biological Process	GO:0000045	autophagosome assembly	AMBRA1	IDA		Human	PMID:20921139
Biological Process	GO:0000045	autophagosome assembly	AMBRA1	IMP		Human	PMID:25215947
Biological Process	GO:0006914	autophagy	Ambra1	IMP	MGI:MGI:3715977	Mouse	PMID:17589504
Biological Process	GO:0006914	autophagy	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:32333458
Biological Process	GO:0000422	autophagy of mitochondrion	AMBRA1	IGI	UniProtKB:O60260	Human	PMID:25215947
Biological Process	GO:0000422	autophagy of mitochondrion	AMBRA1	IGI	UniProtKB:Q99MQ3	Human	PMID:25215947
Biological Process	GO:0009267	cellular response to starvation	Ambra1	IEP		Rat	PMID:25117440|RGD:11552604
Biological Process	GO:0043009	chordate embryonic development	ambra1b	IMP	ZFIN:ZDB-MRPHLNO-140918-3	Zfish	PMID:23348054
Biological Process	GO:0043009	chordate embryonic development	ambra1b	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:23348054
Biological Process	GO:0043009	chordate embryonic development	ambra1b	IMP	ZFIN:ZDB-MRPHLNO-140918-4	Zfish	PMID:23348054
Biological Process	GO:0043009	chordate embryonic development	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-6	Zfish	PMID:23348054
Biological Process	GO:0043009	chordate embryonic development	ambra1a	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:23348054
Biological Process	GO:0043009	chordate embryonic development	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:23348054
Biological Process	GO:0009790	embryo development	Ambra1	IMP	MGI:MGI:3715977	Mouse	PMID:17589504
Biological Process	GO:0007626	locomotory behavior	ambra1b	IMP	ZFIN:ZDB-MRPHLNO-140918-3	Zfish	PMID:24922546
Biological Process	GO:0007626	locomotory behavior	ambra1b	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546
Biological Process	GO:0007626	locomotory behavior	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546
Biological Process	GO:0007626	locomotory behavior	ambra1a	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546
Biological Process	GO:0000423	mitophagy	AMBRA1	IDA		Human	PMID:21753002
Biological Process	GO:0000423	mitophagy	AMBRA1	IMP		Human	PMID:25215947
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Ambra1	IMP		Rat	PMID:25117440|RGD:11552604
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ambra1	IMP	MGI:MGI:3715977	Mouse	PMID:17589504
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ambra1	IMP	MGI:MGI:3715977	Mouse	PMID:17589504
Biological Process	GO:0021915	neural tube development	Ambra1	IMP	MGI:MGI:3715977	Mouse	PMID:17589504
Biological Process	GO:0010508	positive regulation of autophagy	AMBRA1	IDA		Human	PMID:21358617
Biological Process	GO:0010508	positive regulation of autophagy	AMBRA1	IDA		Human	PMID:31123703
Biological Process	GO:0010508	positive regulation of autophagy	AMBRA1	IMP		Human	PMID:32333458
Biological Process	GO:0010508	positive regulation of autophagy	Ambra1	IDA		Mouse	MGI:MGI:6810795|PMID:24980959
Biological Process	GO:0010508	positive regulation of autophagy	Ambra1	IMP		Rat	PMID:25117440|RGD:11552604
Biological Process	GO:1904544	positive regulation of free ubiquitin chain polymerization	AMBRA1	IDA		Human	PMID:31123703
Biological Process	GO:1901526	positive regulation of mitophagy	AMBRA1	IDA		Human	PMID:30217973
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	AMBRA1	IDA		Human	PMID:21753002
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	AMBRA1	IDA		Human	PMID:25438055
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	AMBRA1	IDA		Human	PMID:30513302
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	AMBRA1	IDA		Human	PMID:30513302
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	Ambra1	IMP		Mouse	MGI:MGI:6284097|PMID:30513302
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	AMBRA1	IDA		Human	PMID:33854232
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	AMBRA1	IDA		Human	PMID:33854235
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	AMBRA1	IDA		Human	PMID:33854239
Biological Process	GO:0000209	protein polyubiquitination	AMBRA1	IDA		Human	PMID:30217973
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	AMBRA1	IDA		Human	PMID:25438055
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ambra1	IDA		Mouse	MGI:MGI:6810802|PMID:32616651
Biological Process	GO:0098780	response to mitochondrial depolarisation	AMBRA1	IDA		Human	PMID:21753002
Biological Process	GO:0098780	response to mitochondrial depolarisation	AMBRA1	IGI	UniProtKB:Q9BXM7	Human	PMID:25215947
Biological Process	GO:0031667	response to nutrient levels	Ambra1	IEP		Rat	PMID:23894530|RGD:11552605
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1b	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1b	IMP	ZFIN:ZDB-MRPHLNO-140918-3	Zfish	PMID:24922546
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1b	IMP	ZFIN:ZDB-MRPHLNO-140918-4	Zfish	PMID:24922546
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1a	IGI	ZFIN:ZDB-MRPHLNO-140918-3,ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-3	Zfish	PMID:24922546
Biological Process	GO:0048741	skeletal muscle fiber development	ambra1a	IMP	ZFIN:ZDB-MRPHLNO-140918-5	Zfish	PMID:24922546

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern