Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AMER1
  • Mouse genes Amer1
  • Rat genes Amer1
  • Zfish genes amer1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Amer1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	AMER1	IPI	UniProtKB:P35222	Human	PMID:17510365
Molecular Function	GO:0008013	beta-catenin binding	AMER1	IDA		Human	PMID:21498506
Molecular Function	GO:1904713	beta-catenin destruction complex binding	AMER1	IPI	UniProtKB:O15169|UniProtKB:P25054|UniProtKB:P35222|UniProtKB:Q9UKB1|UniProtKB:Q9Y297	Human	PMID:17510365
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	AMER1	IMP		Human	PMID:17925383
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	AMER1	IDA		Human	PMID:21304492
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:O15169	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P25054	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P35222	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P63208	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:Q14145	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:Q9UKB1	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:Q9Y297	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P25054	Human	PMID:17925383
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:O75581	Human	PMID:21304492
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:O15169	Human	PMID:22682247
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P25054	Human	PMID:24251807
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:Q8N944	Human	PMID:24251807
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:O15169	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P25054	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	AMER1	IPI	UniProtKB:P35222	Human	PMID:26496610
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	AMER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	AMER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	AMER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	AMER1	IDA		Human	PMID:17925383
Cellular Component	GO:0005886	plasma membrane	AMER1	IDA		Human	PMID:21304492
Cellular Component	GO:0005886	plasma membrane	AMER1	IDA		Human	PMID:21498506
Biological Process	GO:0060612	adipose tissue development	Amer1	IMP	MGI:MGI:2446599,MGI:MGI:5086003	Mouse	PMID:21571217
Biological Process	GO:0060348	bone development	Amer1	IMP	MGI:MGI:2446599,MGI:MGI:5086003	Mouse	PMID:21571217
Biological Process	GO:0001822	kidney development	Amer1	IMP	MGI:MGI:2446599,MGI:MGI:5086003	Mouse	PMID:21571217
Biological Process	GO:0072161	mesenchymal cell differentiation involved in kidney development	Amer1	IMP	MGI:MGI:2446599,MGI:MGI:5086003	Mouse	PMID:21571217
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AMER1	IGI	UniProtKB:P28026	Human	PMID:17510365
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AMER1	IMP		Human	PMID:21498506
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	amer1	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-070822-1	Zfish	PMID:17510365
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	amer1	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-070822-2	Zfish	PMID:17510365
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	AMER1	IMP		Human	PMID:21304492
Biological Process	GO:0045732	positive regulation of protein catabolic process	AMER1	IDA		Human	PMID:17510365
Biological Process	GO:0031398	positive regulation of protein ubiquitination	AMER1	IDA		Human	PMID:17510365
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	AMER1	IMP		Human	PMID:17925383

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern