Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AMFR
  • Mouse genes Amfr
  • Rat genes Amfr
  • Zfish genes amfra,amfrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Amfr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1904288	BAT3 complex binding	AMFR	IPI	ComplexPortal:CPX-132	Human	PMID:21636303
Molecular Function	GO:1904288	BAT3 complex binding	AMFR	IDA		Human	PMID:24424410
Molecular Function	GO:0042802	identical protein binding	AMFR	IPI	UniProtKB:Q9UKV5	Human	PMID:17310145
Molecular Function	GO:0042802	identical protein binding	AMFR	IPI	UniProtKB:Q9UKV5	Human	PMID:19223579
Molecular Function	GO:0042802	identical protein binding	AMFR	IPI	UniProtKB:Q9UKV5	Human	PMID:23942235
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:11724934
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60605	Human	PMID:11724934
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O15503	Human	PMID:16168377
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:16275660
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:16407162
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:16407162
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60605	Human	PMID:16407162
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60605	Human	PMID:16462746
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:17681147
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:17681147
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q92890	Human	PMID:17681147
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60605	Human	PMID:19223579
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O15503	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O75477	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O94905	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q9BVT8	Human	PMID:21343306
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O75477	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:O94905	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q9BVT8	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q9H6R6	Human	PMID:22728137
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:23223569
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q9Y679	Human	PMID:23223569
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P60604	Human	PMID:23942235
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P06744	Human	PMID:24810856
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:P55072	Human	PMID:26712280
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q8TCD1	Human	PMID:29275994
Molecular Function	GO:0005515	protein binding	AMFR	IPI	UniProtKB:Q6UX01	Human	PMID:31073040
Molecular Function	GO:0005515	protein binding	Amfr	IPI	UniProtKB:Q02248|UniProtKB:Q8R1K1|UniProtKB:Q9D1E5	Mouse	MGI:MGI:6303730|PMID:31073040
Molecular Function	GO:0005515	protein binding	Amfr	IPI	UniProtKB:O35425	Mouse	MGI:MGI:5796067|PMID:26949185
Molecular Function	GO:0005515	protein binding	Amfr	IPI	UniProtKB:Q01853	Mouse	MGI:MGI:5009406|PMID:16709668
Molecular Function	GO:0005515	protein binding	Amfr	IPI	UniProtKB:Q9JI78	Mouse	MGI:MGI:5009406|PMID:16709668
Molecular Function	GO:0051087	protein-folding chaperone binding	AMFR	IPI	UniProtKB:P46379	Human	PMID:21636303
Molecular Function	GO:0051087	protein-folding chaperone binding	AMFR	IPI	UniProtKB:P46379	Human	PMID:23246001
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	AMFR	IMP		Human	PMID:24424410
Molecular Function	GO:0038023	signaling receptor activity	AMFR	IPI	UniProtKB:P06744	Human	PMID:1649192
Molecular Function	GO:0061630	ubiquitin protein ligase activity	AMFR	IDA		Human	PMID:17310145
Molecular Function	GO:0061630	ubiquitin protein ligase activity	AMFR	IDA		Human	PMID:24424410
Molecular Function	GO:0061630	ubiquitin protein ligase activity	AMFR	IDA		Human	PMID:28604676
Molecular Function	GO:0061630	ubiquitin protein ligase activity	amfra	IDA		Zfish	PMID:25064675
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	AMFR	IDA		Human	PMID:11724934
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	AMFR	IMP		Human	PMID:16168377
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	AMFR	IMP		Human	PMID:17043353
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	AMFR	IDA		Human	PMID:17681147
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	AMFR	IDA		Human	PMID:19103148
Molecular Function	GO:1990381	ubiquitin-specific protease binding	AMFR	IPI	UniProtKB:Q92995	Human	PMID:24424410
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	AMFR	IDA		Human	PMID:24810856
Cellular Component	GO:0005737	cytoplasm	Amfr	IDA		Rat	PMID:10820431|RGD:1643422
Cellular Component	GO:0030425	dendrite	Amfr	IDA		Rat	PMID:10820431|RGD:1643422
Cellular Component	GO:0036513	Derlin-1 retrotranslocation complex	AMFR	IDA		Human	PMID:17872946
Cellular Component	GO:0005783	endoplasmic reticulum	AMFR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	AMFR	IDA		Human	PMID:22728137
Cellular Component	GO:0005783	endoplasmic reticulum	amfra	IDA		Zfish	PMID:25064675
Cellular Component	GO:0005789	endoplasmic reticulum membrane	AMFR	IDA		Human	PMID:11724934
Cellular Component	GO:0005789	endoplasmic reticulum membrane	AMFR	IDA		Human	PMID:17872946
Cellular Component	GO:0005794	Golgi apparatus	AMFR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030426	growth cone	Amfr	IDA		Rat	PMID:10820431|RGD:1643422
Cellular Component	GO:0016020	membrane	AMFR	HDA		Human	PMID:19946888
Cellular Component	GO:0043025	neuronal cell body	Amfr	IDA		Rat	PMID:10820431|RGD:1643422
Cellular Component	GO:0005634	nucleus	Amfr	IDA		Rat	PMID:10820431|RGD:1643422
Cellular Component	GO:0048471	perinuclear region of cytoplasm	AMFR	IDA		Human	PMID:16275660
Cellular Component	GO:0032991	protein-containing complex	AMFR	IDA		Human	PMID:23382219
Biological Process	GO:0007568	aging	Amfr	IEP		Rat	PMID:11902125|RGD:1643424
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	AMFR	IMP		Human	PMID:17157811
Biological Process	GO:0007611	learning or memory	Amfr	IEP		Rat	PMID:11902125|RGD:1643424
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	AMFR	IMP		Human	PMID:31073040
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Amfr	IMP		Mouse	MGI:MGI:6303730|PMID:31073040
Biological Process	GO:0038061	NIK/NF-kappaB signaling	AMFR	IDA		Human	PMID:15327770
Biological Process	GO:0032092	positive regulation of protein binding	AMFR	IMP		Human	PMID:24424410
Biological Process	GO:0051865	protein autoubiquitination	AMFR	IDA		Human	PMID:24810856
Biological Process	GO:0044314	protein K27-linked ubiquitination	AMFR	IDA		Human	PMID:15327770
Biological Process	GO:0070936	protein K48-linked ubiquitination	AMFR	IDA		Human	PMID:12847084
Biological Process	GO:0070936	protein K48-linked ubiquitination	AMFR	IDA		Human	PMID:24424410
Biological Process	GO:0000209	protein polyubiquitination	AMFR	IDA		Human	PMID:17310145
Biological Process	GO:0000209	protein polyubiquitination	AMFR	IDA		Human	PMID:19103148
Biological Process	GO:0000209	protein polyubiquitination	AMFR	IMP		Human	PMID:24810856
Biological Process	GO:0000209	protein polyubiquitination	amfra	IDA		Zfish	PMID:25064675
Biological Process	GO:2000638	regulation of SREBP signaling pathway	Amfr	IMP		Mouse	MGI:MGI:6276494|PMID:22863805
Biological Process	GO:0034976	response to endoplasmic reticulum stress	amfra	IMP	ZFIN:ZDB-GENO-170330-4	Zfish	PMID:25064675
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	AMFR	IDA		Human	PMID:11724934
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	AMFR	IMP		Human	PMID:16168377
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	AMFR	IDA		Human	PMID:17872946
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	AMFR	IMP		Human	PMID:16168377
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	AMFR	IMP		Human	PMID:17043353

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern