Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AMOT
  • Mouse genes Amot
  • Rat genes Amot
  • Zfish genes amot
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Amot

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043532	angiostatin binding	AMOT	IDA		Human	PMID:11257124
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P00747	Human	PMID:11257124
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P35240	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P35240	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:Q68EM7	Human	PMID:21481793
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P35240	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P35240	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P35240	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P46662	Human	PMID:25026211
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:P0DOE7	Human	PMID:25556234
Molecular Function	GO:0005515	protein binding	AMOT	IPI	UniProtKB:Q9Y6K9	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q8VBX6	Mouse	PMID:17397395
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q9D4H4	Mouse	PMID:19590046
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q63ZW7	Mouse	PMID:17397395
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q8VBX6	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q8JZS0	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q63ZW7	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q66T02	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q9JLB2	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q8BTM8	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	PR:Q9JLB0	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Amot	IPI	UniProtKB:Q63648	Rat	PMID:21481793|RGD:8554001
Molecular Function	GO:0038023	signaling receptor activity	AMOT	IDA		Human	PMID:11257124
Cellular Component	GO:0005884	actin filament	AMOT	IDA		Human	PMID:11257124
Cellular Component	GO:0005923	bicellular tight junction	Amot	IDA		Mouse	PMID:17397395
Cellular Component	GO:0030054	cell junction	AMOT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031410	cytoplasmic vesicle	Amot	IDA		Mouse	PMID:17397395
Cellular Component	GO:0030139	endocytic vesicle	AMOT	IDA		Human	PMID:11257124
Cellular Component	GO:0009897	external side of plasma membrane	AMOT	IDA		Human	PMID:11257124
Cellular Component	GO:0030027	lamellipodium	AMOT	IDA		Human	PMID:11257124
Cellular Component	GO:0030027	lamellipodium	Amot	IDA		Mouse	PMID:12902404
Cellular Component	GO:0005654	nucleoplasm	AMOT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001726	ruffle	AMOT	IDA		Human	PMID:11257124
Biological Process	GO:0030036	actin cytoskeleton organization	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0001525	angiogenesis	amot	IGI	ZFIN:ZDB-MRPHLNO-070906-14,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:18824598
Biological Process	GO:0001525	angiogenesis	amot	IGI	ZFIN:ZDB-MRPHLNO-070906-15,ZFIN:ZDB-MRPHLNO-090421-1	Zfish	PMID:18757825
Biological Process	GO:0001525	angiogenesis	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-15	Zfish	PMID:17699752
Biological Process	GO:0001525	angiogenesis	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-15	Zfish	PMID:18757825
Biological Process	GO:0001525	angiogenesis	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:17699752
Biological Process	GO:0001568	blood vessel development	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:19590046
Biological Process	GO:0043534	blood vessel endothelial cell migration	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0043534	blood vessel endothelial cell migration	amot	IGI	ZFIN:ZDB-MRPHLNO-070906-14,ZFIN:ZDB-MRPHLNO-090908-5	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:18824598
Biological Process	GO:0043534	blood vessel endothelial cell migration	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-15	Zfish	PMID:17699752
Biological Process	GO:0043534	blood vessel endothelial cell migration	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:17699752
Biological Process	GO:0048514	blood vessel morphogenesis	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0042074	cell migration involved in gastrulation	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:12676095
Biological Process	GO:0006935	chemotaxis	Amot	IMP		Mouse	PMID:12902404
Biological Process	GO:0009790	embryo development	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:12676095
Biological Process	GO:0003365	establishment of cell polarity involved in ameboidal cell migration	Amot	IMP		Mouse	PMID:18824598
Biological Process	GO:0003365	establishment of cell polarity involved in ameboidal cell migration	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0090162	establishment of epithelial cell polarity	Amot	IMP		Mouse	PMID:18824598
Biological Process	GO:0090162	establishment of epithelial cell polarity	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0007163	establishment or maintenance of cell polarity	amot	IMP	ZFIN:ZDB-MRPHLNO-070906-14	Zfish	PMID:19590046
Biological Process	GO:0001702	gastrulation with mouth forming second	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:12676095
Biological Process	GO:0035329	hippo signaling	AMOT	IGI	UniProtKB:P46937	Human	PMID:21205866
Biological Process	GO:0001701	in utero embryonic development	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:12676095
Biological Process	GO:0016525	negative regulation of angiogenesis	AMOT	IDA		Human	PMID:11257124
Biological Process	GO:0034260	negative regulation of GTPase activity	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0040019	positive regulation of embryonic development	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:12676095
Biological Process	GO:0008104	protein localization	Amot	IMP		Mouse	PMID:18824598
Biological Process	GO:0030334	regulation of cell migration	AMOT	IDA		Human	PMID:11257124
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction	Amot	IMP	MGI:MGI:2656627	Mouse	PMID:17699752
Biological Process	GO:0001570	vasculogenesis	Amot	IMP		Mouse	PMID:12902404

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern