Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANG
  • Mouse genes Ang3
  • Rat genes Ang2
  • Zfish genes rnasel2,rnasel3,rnasel4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ang3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	ANG	IDA		Human	PMID:11782452
Molecular Function	GO:0003779	actin binding	ANG	IDA		Human	PMID:7679494
Molecular Function	GO:0005507	copper ion binding	ANG	IDA		Human	PMID:9245697
Molecular Function	GO:0008201	heparin binding	ANG	IDA		Human	PMID:10103013
Molecular Function	GO:0042277	peptide binding	ANG	IDA		Human	PMID:11782452
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P13489	Human	PMID:10413501
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P35609	Human	PMID:15737636
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P19883	Human	PMID:17991437
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:Q03405	Human	PMID:24457100
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P13489	Human	PMID:2742853
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P13489	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P12004	Human	PMID:28777577
Molecular Function	GO:0005515	protein binding	ANG	IPI	UniProtKB:P13489	Human	PMID:3470787
Molecular Function	GO:0042803	protein homodimerization activity	ANG	IDA		Human	PMID:25372031
Molecular Function	GO:0004540	RNA nuclease activity	ANG	IDA		Human	PMID:2424496
Molecular Function	GO:0004540	RNA nuclease activity	ANG	IDA		Human	PMID:2730651
Molecular Function	GO:0004540	RNA nuclease activity	Ang3	IDA		Mouse	PMID:23170778
Molecular Function	GO:0004540	RNA nuclease activity	rnasel2	IDA		Zfish	PMID:16861230
Molecular Function	GO:0004540	RNA nuclease activity	rnasel2	IDA		Zfish	PMID:17347156
Molecular Function	GO:0004540	RNA nuclease activity	rnasel3	IDA		Zfish	PMID:16861230
Molecular Function	GO:0004540	RNA nuclease activity	rnasel3	IDA		Zfish	PMID:17347156
Molecular Function	GO:0004540	RNA nuclease activity	rnasel3	IDA		Zfish	PMID:18508078
Molecular Function	GO:0004540	RNA nuclease activity	rnasel4	IDA		Zfish	PMID:17347156
Molecular Function	GO:0005102	signaling receptor binding	ANG	IDA		Human	PMID:9122172
Cellular Component	GO:0015629	actin cytoskeleton	ANG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032311	angiogenin-PRI complex	ANG	IDA		Human	PMID:3470787
Cellular Component	GO:0032311	angiogenin-PRI complex	ANG	IPI	UniProtKB:P13489	Human	PMID:3470787
Cellular Component	GO:0005604	basement membrane	ANG	IDA		Human	PMID:15166501
Cellular Component	GO:0005694	chromosome	ANG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	ANG	IDA		Human	PMID:16461950
Cellular Component	GO:0005615	extracellular space	ANG	IDA		Human	PMID:16490744
Cellular Component	GO:0005615	extracellular space	ANG	IDA		Human	PMID:3663649
Cellular Component	GO:0005730	nucleolus	ANG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ANG	IDA		Human	PMID:10649442
Cellular Component	GO:0005634	nucleus	ANG	IDA		Human	PMID:15735021
Cellular Component	GO:0005634	nucleus	ANG	IDA		Human	PMID:25372031
Biological Process	GO:0032431	activation of phospholipase A2 activity	ANG	IMP		Human	PMID:2646638
Biological Process	GO:0007202	activation of phospholipase C activity	ANG	IMP		Human	PMID:2457905
Biological Process	GO:0032148	activation of protein kinase B activity	ANG	IMP		Human	PMID:17125737
Biological Process	GO:0001525	angiogenesis	ANG	IDA		Human	PMID:8448182
Biological Process	GO:0001525	angiogenesis	ANG	IMP		Human	PMID:17125737
Biological Process	GO:0001525	angiogenesis	ANG	IMP		Human	PMID:2479414
Biological Process	GO:0001525	angiogenesis	rnasel2	IDA		Zfish	PMID:16861230
Biological Process	GO:0001525	angiogenesis	rnasel4	IDA		Zfish	PMID:21050179
Biological Process	GO:0016477	cell migration	ANG	IMP		Human	PMID:17125737
Biological Process	GO:0071260	cellular response to mechanical stimulus	Ang2	IEP		Rat	PMID:19012730|RGD:8662390
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel2	IDA		Zfish	PMID:21050179
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel2	IDA		Zfish	PMID:17347156
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel3	IDA		Zfish	PMID:17347156
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel3	IDA		Zfish	PMID:20214681
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel3	IDA		Zfish	PMID:21050179
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel4	IDA		Zfish	PMID:21050179
Biological Process	GO:0050829	defense response to Gram-negative bacterium	rnasel4	IDA		Zfish	PMID:17347156
Biological Process	GO:0050830	defense response to Gram-positive bacterium	rnasel2	IDA		Zfish	PMID:21050179
Biological Process	GO:0050830	defense response to Gram-positive bacterium	rnasel2	IDA		Zfish	PMID:17347156
Biological Process	GO:0050830	defense response to Gram-positive bacterium	rnasel3	IDA		Zfish	PMID:17347156
Biological Process	GO:0050830	defense response to Gram-positive bacterium	rnasel3	IDA		Zfish	PMID:21050179
Biological Process	GO:0050830	defense response to Gram-positive bacterium	rnasel4	IDA		Zfish	PMID:17347156
Biological Process	GO:0006651	diacylglycerol biosynthetic process	ANG	IDA		Human	PMID:2457905
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ANG	IDA		Human	PMID:10103013
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ANG	IDA		Human	PMID:9122172
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ANG	IDA		Human	PMID:9707554
Biological Process	GO:0042327	positive regulation of phosphorylation	ANG	IDA		Human	PMID:17125737
Biological Process	GO:0050714	positive regulation of protein secretion	ANG	IDA		Human	PMID:2646638
Biological Process	GO:0009725	response to hormone	ANG	IDA		Human	PMID:10999833
Biological Process	GO:0001666	response to hypoxia	ANG	IDA		Human	PMID:10999833
Biological Process	GO:0001666	response to hypoxia	ANG	IDA		Human	PMID:15979542
Biological Process	GO:0001666	response to hypoxia	ANG	IDA		Human	PMID:16490744
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	Ang3	IDA		Mouse	MGI:MGI:5563005|PMID:23170778
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	rnasel4	IDA		Zfish	PMID:17347156|ZFIN:ZDB-PUB-070310-14
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	rnasel3	IDA		Zfish	PMID:17347156|ZFIN:ZDB-PUB-070310-14
Biological Process	GO:0009303	rRNA transcription	ANG	IMP		Human	PMID:15735021

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern