Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANGPT1
  • Mouse genes Angpt1
  • Rat genes Angpt1
  • Zfish genes angpt1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Angpt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	ANGPT1	IPI	UniProtKB:Q15389	Human	PMID:29106382
Molecular Function	GO:0042802	identical protein binding	Angpt1	IPI	RGD:628896	Rat	PMID:15056293|RGD:1358283
Molecular Function	GO:0005515	protein binding	ANGPT1	IPI	UniProtKB:Q02763	Human	PMID:20708158
Molecular Function	GO:0005515	protein binding	ANGPT1	IPI	UniProtKB:Q02763	Human	PMID:29106382
Molecular Function	GO:0005515	protein binding	Angpt1	IPI	PR:A2AVA0	Mouse	PMID:28179430
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ANGPT1	IPI	UniProtKB:Q02763	Human	PMID:19922791
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ANGPT1	IPI	UniProtKB:Q02763	Human	PMID:8980223
Molecular Function	GO:0005102	signaling receptor binding	Angpt1	IPI	PR:Q02858	Mouse	PMID:8980223
Cellular Component	GO:0070062	extracellular exosome	ANGPT1	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	ANGPT1	IDA		Human	PMID:10218485
Cellular Component	GO:0005615	extracellular space	ANGPT1	IDA		Human	PMID:8980223
Cellular Component	GO:0005615	extracellular space	Angpt1	IDA		Rat	PMID:15056293|RGD:1358283
Cellular Component	GO:0045121	membrane raft	ANGPT1	IDA		Human	PMID:19615361
Cellular Component	GO:0005902	microvillus	ANGPT1	IDA		Human	PMID:19424712
Cellular Component	GO:0005886	plasma membrane	ANGPT1	IDA		Human	PMID:19424712
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	ANGPT1	IDA		Human	PMID:19424712
Biological Process	GO:0001525	angiogenesis	Angpt1	IMP		Mouse	PMID:18505784
Biological Process	GO:0001525	angiogenesis	Angpt1	IDA		Mouse	PMID:10617467
Biological Process	GO:0031100	animal organ regeneration	Angpt1	IEP		Rat	PMID:16437624|RGD:1626165
Biological Process	GO:0001568	blood vessel development	angpt1	IGI	ZFIN:ZDB-GENO-100622-10	Zfish	PMID:20156556
Biological Process	GO:0007420	brain development	angpt1	IMP	ZFIN:ZDB-MRPHLNO-100609-1	Zfish	PMID:26108626
Biological Process	GO:0031589	cell-substrate adhesion	Angpt1	IDA		Mouse	PMID:9846489
Biological Process	GO:0072012	glomerulus vasculature development	Angpt1	IDA		Mouse	PMID:11507774
Biological Process	GO:0072012	glomerulus vasculature development	Angpt1	IMP		Rat	PMID:20056745|RGD:8554659
Biological Process	GO:0030097	hemopoiesis	Angpt1	IDA		Mouse	PMID:15260986
Biological Process	GO:0030210	heparin biosynthetic process	ANGPT1	IDA		Human	PMID:19297368
Biological Process	GO:0001701	in utero embryonic development	Angpt1	IGI	MGI:MGI:99906	Mouse	PMID:11172728
Biological Process	GO:0001701	in utero embryonic development	Angpt1	IMP	MGI:MGI:2180145	Mouse	PMID:11172728
Biological Process	GO:0097421	liver regeneration	Angpt1	IEP		Rat	PMID:11549276|RGD:704403
Biological Process	GO:0043066	negative regulation of apoptotic process	ANGPT1	IDA		Human	PMID:10218485
Biological Process	GO:0043066	negative regulation of apoptotic process	ANGPT1	IDA		Human	PMID:12958144
Biological Process	GO:0043066	negative regulation of apoptotic process	Angpt1	IMP		Rat	PMID:17989359|RGD:1643337
Biological Process	GO:0007162	negative regulation of cell adhesion	ANGPT1	IDA		Human	PMID:19674970
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ANGPT1	IDA		Human	PMID:19674970
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Angpt1	IGI	MGI:MGI:98664	Mouse	PMID:19409199
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Angpt1	IDA		Mouse	PMID:19409199
Biological Process	GO:0042308	negative regulation of protein import into nucleus	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:0043116	negative regulation of vascular permeability	ANGPT1	IDA		Human	PMID:14978158
Biological Process	GO:0043116	negative regulation of vascular permeability	ANGPT1	IDA		Human	PMID:19297368
Biological Process	GO:0043116	negative regulation of vascular permeability	Angpt1	IDA		Mouse	PMID:10617467
Biological Process	GO:0043116	negative regulation of vascular permeability	Angpt1	IDA		Mouse	PMID:17562701
Biological Process	GO:0051402	neuron apoptotic process	Angpt1	IDA		Mouse	PMID:19409199
Biological Process	GO:0051402	neuron apoptotic process	Angpt1	IGI	MGI:MGI:98664	Mouse	PMID:19409199
Biological Process	GO:0001541	ovarian follicle development	Angpt1	IMP		Rat	PMID:17989359|RGD:1643337
Biological Process	GO:0050918	positive chemotaxis	ANGPT1	IDA		Human	PMID:9660821
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ANGPT1	IDA		Human	PMID:9660821
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	ANGPT1	IMP		Human	PMID:19148554
Biological Process	GO:0045785	positive regulation of cell adhesion	Angpt1	IDA		Mouse	PMID:15260986
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ANGPT1	IDA		Human	PMID:12958144
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ANGPT1	IDA		Human	PMID:18425120
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ANGPT1	IDA		Human	PMID:19615361
Biological Process	GO:0010628	positive regulation of gene expression	ANGPT1	IMP	UniProtKB:Q9UDY2	Human	PMID:19148554
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Angpt1	IDA		Mouse	PMID:19409199
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ANGPT1	IDA		Human	PMID:15851516
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ANGPT1	IDA		Human	PMID:19689429
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Angpt1	IDA		Mouse	PMID:19409199
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Angpt1	IDA		Mouse	PMID:8980223
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Angpt1	IDA		Mouse	PMID:19409199
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ANGPT1	IDA		Human	PMID:18425120
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ANGPT1	IDA		Human	PMID:19615361
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ANGPT1	IMP		Human	PMID:19148554
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ANGPT1	IDA		Human	PMID:19689429
Biological Process	GO:0002092	positive regulation of receptor internalization	ANGPT1	IDA		Human	PMID:19424712
Biological Process	GO:0034394	protein localization to cell surface	ANGPT1	IDA		Human	PMID:19615361
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Angpt1	IGI	MGI:MGI:98664	Mouse	PMID:20060382
Biological Process	GO:2000446	regulation of macrophage migration inhibitory factor signaling pathway	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:0043393	regulation of protein binding	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	ANGPT1	IDA		Human	PMID:19733541
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Angpt1	IDA		Mouse	PMID:20060382
Biological Process	GO:0043627	response to estrogen	Angpt1	IEP		Rat	PMID:15637314|RGD:1626166
Biological Process	GO:0001666	response to hypoxia	Angpt1	IEP		Rat	PMID:11129953|RGD:1626169
Biological Process	GO:0033552	response to vitamin B3	Angpt1	IEP		Rat	PMID:17557352|RGD:1643100
Biological Process	GO:0002040	sprouting angiogenesis	ANGPT1	IDA		Human	PMID:10218485
Biological Process	GO:0002040	sprouting angiogenesis	ANGPT1	IDA		Human	PMID:9560344
Biological Process	GO:0048014	Tie signaling pathway	ANGPT1	IDA		Human	PMID:19689429
Biological Process	GO:0048014	Tie signaling pathway	ANGPT1	IDA		Human	PMID:19922791
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Angpt1	IDA		Mouse	PMID:8980224

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern