Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANGPTL3
  • Mouse genes Angptl3
  • Rat genes Angptl3
  • Zfish genes angptl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Angptl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004857	enzyme inhibitor activity	Angptl3	IDA		Mouse	MGI:MGI:2386514|PMID:12097324
Molecular Function	GO:0008083	growth factor activity	ANGPTL3	IDA		Human	PMID:11877390
Molecular Function	GO:0005178	integrin binding	ANGPTL3	IPI	UniProtKB:P06756	Human	PMID:11877390
Molecular Function	GO:0004859	phospholipase inhibitor activity	ANGPTL3	IDA		Human	PMID:17110602
Cellular Component	GO:0009986	cell surface	ANGPTL3	IDA		Human	PMID:12565906
Cellular Component	GO:0009986	cell surface	Angptl3	IDA		Mouse	PMID:23918928
Cellular Component	GO:0005769	early endosome	Angptl3	IDA		Mouse	PMID:23918928
Cellular Component	GO:0005615	extracellular space	ANGPTL3	IDA		Human	PMID:17110602
Cellular Component	GO:0005794	Golgi apparatus	Angptl3	IDA		Mouse	PMID:23918928
Biological Process	GO:0055090	acylglycerol homeostasis	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0055090	acylglycerol homeostasis	Angptl3	IMP		Mouse	MGI:MGI:3773779|PMID:17110602
Biological Process	GO:0048844	artery morphogenesis	Angptl3	IMP		Mouse	MGI:MGI:2664626|PMID:12671033
Biological Process	GO:0007160	cell-matrix adhesion	ANGPTL3	IPI	UniProtKB:P06756	Human	PMID:11877390
Biological Process	GO:0042632	cholesterol homeostasis	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0042632	cholesterol homeostasis	Angptl3	IMP		Mouse	MGI:MGI:3773779|PMID:17110602
Biological Process	GO:0008203	cholesterol metabolic process	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0006631	fatty acid metabolic process	ANGPTL3	IDA		Human	PMID:12565906
Biological Process	GO:0006071	glycerol metabolic process	ANGPTL3	IDA		Human	PMID:12565906
Biological Process	GO:0072574	hepatocyte proliferation	angptl3	IMP	ZFIN:ZDB-MRPHLNO-150109-5	Zfish	PMID:24685482
Biological Process	GO:0055088	lipid homeostasis	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0006629	lipid metabolic process	angptl3	IMP	ZFIN:ZDB-MRPHLNO-150109-5	Zfish	PMID:24685482
Biological Process	GO:0019915	lipid storage	ANGPTL3	IDA		Human	PMID:12565906
Biological Process	GO:0001889	liver development	angptl3	IMP	ZFIN:ZDB-MRPHLNO-150109-5	Zfish	PMID:24685482
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	ANGPTL3	IDA		Human	PMID:19542565
Biological Process	GO:0010519	negative regulation of phospholipase activity	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0010519	negative regulation of phospholipase activity	Angptl3	IMP		Mouse	MGI:MGI:3773779|PMID:17110602
Biological Process	GO:0009395	phospholipid catabolic process	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0055091	phospholipid homeostasis	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0055091	phospholipid homeostasis	Angptl3	IMP		Mouse	MGI:MGI:3773779|PMID:17110602
Biological Process	GO:0006644	phospholipid metabolic process	ANGPTL3	IDA		Human	PMID:17110602
Biological Process	GO:0045766	positive regulation of angiogenesis	ANGPTL3	IDA		Human	PMID:11877390
Biological Process	GO:0030335	positive regulation of cell migration	ANGPTL3	IDA		Human	PMID:11877390
Biological Process	GO:0050996	positive regulation of lipid catabolic process	ANGPTL3	IDA		Human	PMID:12565906
Biological Process	GO:0009725	response to hormone	Angptl3	IEP		Rat	PMID:16505486|RGD:2313115
Biological Process	GO:0007165	signal transduction	ANGPTL3	IDA		Human	PMID:11877390
Biological Process	GO:0070328	triglyceride homeostasis	ANGPTL3	IGI	UniProtKB:Q6UXH0	Human	PMID:23150577
Biological Process	GO:0070328	triglyceride homeostasis	Angptl3	IMP		Mouse	MGI:MGI:4412214|PMID:19542565

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern