Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ANK3
  • Mouse genes Ank3
  • Rat genes Ank3
  • Zfish genes ank3a,ank3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ank3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	Ank3	IPI	UniProtKB:P12830	Rat	PMID:17620337|RGD:8693373
Molecular Function	GO:0008092	cytoskeletal protein binding	Ank3	IPI	UniProtKB:D3ZHA0	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0008092	cytoskeletal protein binding	Ank3	IPI	UniProtKB:P30427	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0008092	cytoskeletal protein binding	Ank3	IPI	UniProtKB:Q14315	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0008092	cytoskeletal protein binding	Ank3	IPI	UniProtKB:Q15149	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	Ank3	IPI	UniProtKB:B3KU38	Rat	PMID:25950943|RGD:13800538
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	Ank3	IPI	UniProtKB:P0DPB3	Rat	PMID:25950943|RGD:13800538
Molecular Function	GO:0005515	protein binding	ANK3	IPI	UniProtKB:Q15796	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	ANK3	IPI	UniProtKB:Q9H310	Human	PMID:15611082
Molecular Function	GO:0005515	protein binding	ANK3	IPI	UniProtKB:O00203-1	Human	PMID:19934039
Molecular Function	GO:0005515	protein binding	ANK3	IPI	UniProtKB:Q15796	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	Ank3	IPI	MGI:MGI:1341265	Mouse	PMID:20877009
Molecular Function	GO:0005515	protein binding	Ank3	IPI	PR:Q8BIL5	Mouse	PMID:15823567
Molecular Function	GO:0005515	protein binding	Ank3	IPI	MGI:MGI:1890574	Mouse	PMID:20877009
Molecular Function	GO:0005515	protein binding	Ank3	IPI	RGD:2955	Rat	PMID:12805291|RGD:9685703
Molecular Function	GO:0005515	protein binding	Ank3	IPI	UniProtKB:Q14315	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0005515	protein binding	Ank3	IPI	RGD:1359297	Rat	PMID:21551097|RGD:6767287
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Ank3	IDA		Rat	PMID:17620337|RGD:8693373
Molecular Function	GO:0030507	spectrin binding	Ank3	IDA		Rat	PMID:17620337|RGD:8693373
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ANK3	IMP		Human	PMID:17620337
Molecular Function	GO:0044325	transmembrane transporter binding	Ank3	IPI	UniProtKB:Q09470	Mouse	MGI:MGI:5613458|PMID:23903368
Molecular Function	GO:0044325	transmembrane transporter binding	Ank3	IPI	UniProtKB:P15389	Rat	PMID:15579534|RGD:6484228
Molecular Function	GO:0044325	transmembrane transporter binding	Ank3	IPI	UniProtKB:O43526	Rat	PMID:16525039|RGD:8554229
Cellular Component	GO:0030424	axon	Ank3	IDA		Mouse	PMID:15479642
Cellular Component	GO:0030424	axon	Ank3	IDA		Rat	PMID:17709431|RGD:14392774
Cellular Component	GO:0043194	axon initial segment	ANK3	IDA		Human	PMID:27356871
Cellular Component	GO:0043194	axon initial segment	Ank3	IMP		Mouse	MGI:MGI:6212949|PMID:25950943
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Mouse	MGI:MGI:5426783|PMID:11724816
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Mouse	MGI:MGI:5883190|PMID:27356871
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Mouse	PMID:26671463
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Mouse	PMID:20877009
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Rat	PMID:11724816|RGD:8553674
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Rat	PMID:21551097|RGD:6767287
Cellular Component	GO:0043194	axon initial segment	Ank3	IMP		Rat	PMID:25950943|RGD:13800538
Cellular Component	GO:0043194	axon initial segment	Ank3	IDA		Rat	PMID:28426968|RGD:13514087
Cellular Component	GO:0009925	basal plasma membrane	ANK3	IDA		Human	PMID:21223964
Cellular Component	GO:0016323	basolateral plasma membrane	ANK3	IDA		Human	PMID:15611082
Cellular Component	GO:0005923	bicellular tight junction	ANK3	IDA		Human	PMID:14757759
Cellular Component	GO:0009986	cell surface	Ank3	IDA		Rat	PMID:21223964|RGD:8554309
Cellular Component	GO:0043034	costamere	Ank3	IDA		Rat	PMID:11171381|RGD:153344569
Cellular Component	GO:0005737	cytoplasm	Ank3	IDA		Rat	PMID:11796721|RGD:619703
Cellular Component	GO:0030425	dendrite	Ank3	IDA		Rat	PMID:18786578|RGD:6767291
Cellular Component	GO:0014704	intercalated disc	Ank3	IDA		Mouse	PMID:26187182
Cellular Component	GO:0014704	intercalated disc	Ank3	IDA		Mouse	PMID:20877009
Cellular Component	GO:0014704	intercalated disc	Ank3	IDA		Rat	PMID:15579534|RGD:6484228
Cellular Component	GO:0014704	intercalated disc	Ank3	IDA		Rat	PMID:20467587|RGD:6767289
Cellular Component	GO:0016328	lateral plasma membrane	ANK3	IDA		Human	PMID:14757759
Cellular Component	GO:0016020	membrane	Ank3	IDA		Mouse	PMID:7615634
Cellular Component	GO:0016020	membrane	Ank3	IDA		Rat	PMID:27824361|RGD:153344561
Cellular Component	GO:0031594	neuromuscular junction	Ank3	IDA		Rat	PMID:12657669|RGD:6767302
Cellular Component	GO:0043005	neuron projection	Ank3	IDA		Rat	PMID:12036953|RGD:625497
Cellular Component	GO:0033268	node of Ranvier	Ank3	IDA		Mouse	MGI:MGI:6148385|PMID:28426968
Cellular Component	GO:0033268	node of Ranvier	Ank3	IDA		Mouse	MGI:MGI:5426783|PMID:11724816
Cellular Component	GO:0033268	node of Ranvier	Ank3	IDA		Rat	PMID:17548513|RGD:6767298
Cellular Component	GO:0033268	node of Ranvier	Ank3	IDA		Rat	PMID:17709431|RGD:14392774
Cellular Component	GO:0033268	node of Ranvier	Ank3	IDA		Rat	PMID:28426968|RGD:13514087
Cellular Component	GO:0033270	paranode region of axon	Ank3	IDA		Mouse	PMID:20188654
Cellular Component	GO:0005886	plasma membrane	ANK3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Ank3	IDA		Rat	PMID:16525039|RGD:8554229
Cellular Component	GO:0005886	plasma membrane	Ank3	IDA		Rat	PMID:17620337|RGD:8693373
Cellular Component	GO:0005886	plasma membrane	Ank3	IDA		Rat	PMID:18180363|RGD:6767295
Cellular Component	GO:0005886	plasma membrane	Ank3	IDA		Rat	PMID:9744885|RGD:631998
Cellular Component	GO:0014069	postsynaptic density	Ank3	IDA		Rat	PMID:27824361|RGD:153344561
Cellular Component	GO:0045211	postsynaptic membrane	Ank3	IDA		Rat	PMID:11796721|RGD:619703
Cellular Component	GO:0045211	postsynaptic membrane	Ank3	IDA		Rat	PMID:9664041|RGD:631996
Cellular Component	GO:0042383	sarcolemma	ANK3	IDA		Human	PMID:21223964
Cellular Component	GO:0042383	sarcolemma	Ank3	IDA		Rat	PMID:11796721|RGD:619703
Cellular Component	GO:0042383	sarcolemma	Ank3	IDA		Rat	PMID:15953600|RGD:153344571
Cellular Component	GO:0042383	sarcolemma	Ank3	IDA		Rat	PMID:21223964|RGD:8554309
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ank3	IDA		Rat	PMID:9664041|RGD:631996
Cellular Component	GO:0014731	spectrin-associated cytoskeleton	Ank3	IDA		Rat	PMID:17620337|RGD:8693373
Cellular Component	GO:0045202	synapse	Ank3	IDA		Mouse	PMID:10995443
Cellular Component	GO:0030315	T-tubule	Ank3	IDA		Rat	PMID:15579534|RGD:6484228
Cellular Component	GO:0030018	Z disc	Ank3	IDA		Rat	PMID:9664041|RGD:631996
Biological Process	GO:0008089	anterograde axonal transport	Ank3	IMP		Rat	PMID:31474508|RGD:153344605
Biological Process	GO:0061564	axon development	Ank3	IMP		Rat	PMID:27098687|RGD:11535813
Biological Process	GO:0007411	axon guidance	Ank3	IMP	MGI:MGI:2179751	Mouse	PMID:15479642
Biological Process	GO:0007409	axonogenesis	Ank3	IMP		Mouse	MGI:MGI:5426783|PMID:11724816
Biological Process	GO:0071286	cellular response to magnesium ion	Ank3	IMP		Mouse	MGI:MGI:5613458|PMID:23903368
Biological Process	GO:0045162	clustering of voltage-gated sodium channels	Ank3	IMP		Rat	PMID:17709431|RGD:14392774
Biological Process	GO:0045184	establishment of protein localization	ANK3	IMP		Human	PMID:15611082
Biological Process	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	Ank3	IMP		Rat	PMID:27098687|RGD:11535813
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	ANK3	IMP		Human	PMID:17620337
Biological Process	GO:0010960	magnesium ion homeostasis	Ank3	IMP		Mouse	MGI:MGI:5613458|PMID:23903368
Biological Process	GO:0032507	maintenance of protein location in cell	Ank3	IMP		Rat	PMID:27098687|RGD:11535813
Biological Process	GO:0072660	maintenance of protein location in plasma membrane	ANK3	IGI	UniProtKB:P12830	Human	PMID:17620337
Biological Process	GO:0071709	membrane assembly	ANK3	IMP		Human	PMID:14757759
Biological Process	GO:0071709	membrane assembly	ANK3	IMP		Human	PMID:17620337
Biological Process	GO:0071709	membrane assembly	Ank3	IGI	UniProtKB:Q12955	Rat	PMID:14757759|RGD:8693361
Biological Process	GO:0000281	mitotic cytokinesis	ANK3	IMP		Human	PMID:14757759
Biological Process	GO:0000281	mitotic cytokinesis	ANK3	IMP		Human	PMID:17620337
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	Ank3	IMP		Mouse	MGI:MGI:5613458|PMID:23903368
Biological Process	GO:0045806	negative regulation of endocytosis	Ank3	IMP		Rat	PMID:31474508|RGD:153344605
Biological Process	GO:0007528	neuromuscular junction development	Ank3	IEP		Rat	PMID:12657669|RGD:6767302
Biological Process	GO:0019228	neuronal action potential	Ank3	IMP		Mouse	MGI:MGI:1315159|PMID:9832557
Biological Process	GO:0007009	plasma membrane organization	ANK3	IMP		Human	PMID:17620337
Biological Process	GO:2001259	positive regulation of cation channel activity	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0010650	positive regulation of cell communication by electrical coupling	Ank3	IMP		Rat	PMID:21617128|RGD:6767286
Biological Process	GO:0010628	positive regulation of gene expression	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	Ank3	IMP		Rat	PMID:21617128|RGD:6767286
Biological Process	GO:1900827	positive regulation of membrane depolarization during cardiac muscle cell action potential	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0045838	positive regulation of membrane potential	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Ank3	IMP		Rat	PMID:29079505|RGD:153344581
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0010765	positive regulation of sodium ion transport	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0099612	protein localization to axon	Ank3	IMP		Mouse	PMID:26671463
Biological Process	GO:0099612	protein localization to axon	Ank3	IMP		Rat	PMID:25950943|RGD:13800538
Biological Process	GO:0099612	protein localization to axon	Ank3	IMP		Rat	PMID:27098687|RGD:11535813
Biological Process	GO:0072659	protein localization to plasma membrane	ANK3	IMP		Human	PMID:14757759
Biological Process	GO:0072659	protein localization to plasma membrane	ANK3	IMP		Human	PMID:17620337
Biological Process	GO:0072659	protein localization to plasma membrane	ANK3	IGI	UniProtKB:O70511	Human	PMID:18180363
Biological Process	GO:0072659	protein localization to plasma membrane	Ank3	IDA		Mouse	MGI:MGI:5426783|PMID:11724816
Biological Process	GO:0072659	protein localization to plasma membrane	Ank3	IMP		Mouse	MGI:MGI:3617955|PMID:16525039
Biological Process	GO:0072659	protein localization to plasma membrane	Ank3	IMP		Mouse	MGI:MGI:3722194|PMID:17620337
Biological Process	GO:0072659	protein localization to plasma membrane	Ank3	IGI	UniProtKB:Q12955	Rat	PMID:14757759|RGD:8693361
Biological Process	GO:0072659	protein localization to plasma membrane	Ank3	IMP		Rat	PMID:18180363|RGD:6767295
Biological Process	GO:0043266	regulation of potassium ion transport	Ank3	IDA		Rat	PMID:16525039|RGD:8554229
Biological Process	GO:1903533	regulation of protein targeting	Ank3	IMP		Rat	PMID:18094255|RGD:153344583
Biological Process	GO:0035902	response to immobilization stress	Ank3	IEP		Rat	PMID:27824361|RGD:153344561
Biological Process	GO:0050808	synapse organization	Ank3	IMP	MGI:MGI:2179751	Mouse	PMID:15479642

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern