Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Anxa2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ANXA2,ANXA2P2
- Mouse genes Anxa2
- Rat genes Anxa2
- Zfish genes anxa2a,anxa2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Anxa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0044730	bone sialoprotein binding	Anxa2	IPI	RGD:2525	Rat	PMID:23525114\|RGD:12911212
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion	ANXA2	HDA		Human	PMID:25468996
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ANXA2	IDA		Human	PMID:2138016
Molecular Function	GO:0048306	calcium-dependent protein binding	ANXA2	IPI	UniProtKB:P01023	Human	PMID:15226301
Molecular Function	GO:0042802	identical protein binding	ANXA2	IPI	UniProtKB:P07355	Human	PMID:18799458
Molecular Function	GO:0042802	identical protein binding	ANXA2	IPI	UniProtKB:P07355	Human	PMID:26812398
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ANXA2	IMP		Human	PMID:23861394
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Anxa2	IDA		Rat	PMID:14734570\|RGD:1578381
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	ANXA2	IDA		Human	PMID:3013422
Molecular Function	GO:0002020	protease binding	ANXA2	IPI	UniProtKB:Q8NBP7	Human	PMID:22848640
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P13688-8	Human	PMID:14522961
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q8NBP7	Human	PMID:18799458
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P06703	Human	PMID:19724273
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P40692	Human	PMID:20706999
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P12004	Human	PMID:20849852
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q9NUX5	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P10636-8	Human	PMID:21339331
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q8NEU8\|UniProtKB:Q9UKG1	Human	PMID:21645192
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:O43405	Human	PMID:21886777
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q99IB8:PRO_0000045602	Human	PMID:22301157
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:B7UM99	Human	PMID:22587461
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q15599	Human	PMID:22587461
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q7DB77	Human	PMID:22587461
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:23861394
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:24457100
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P00533	Human	PMID:25136068
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P15363	Human	PMID:25136068
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P75409	Human	PMID:25139904
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q14508	Human	PMID:25362534
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P12004	Human	PMID:26030842
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P15363	Human	PMID:26812398
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P26447	Human	PMID:28669632
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:28669632
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P10636-8	Human	PMID:29636414
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q15811-1	Human	PMID:31160551
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:Q14508	Human	PMID:31210752
Molecular Function	GO:0005515	protein binding	ANXA2	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Anxa2	IPI	UniProtKB:P08207	Mouse	MGI:MGI:5469743\|PMID:23415230
Molecular Function	GO:0005515	protein binding	Anxa2	IPI	PR:Q9ESD7	Mouse	PMID:14506282
Molecular Function	GO:0005515	protein binding	Anxa2	IPI	PR:Q9ESD7	Mouse	PMID:20405035
Molecular Function	GO:0003723	RNA binding	ANXA2	HDA		Human	PMID:22658674
Molecular Function	GO:0044548	S100 protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:14699089
Molecular Function	GO:0044548	S100 protein binding	ANXA2	IPI	UniProtKB:P60903	Human	PMID:23091277
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ANXA2	IDA		Human	PMID:22848640
Molecular Function	GO:0031267	small GTPase binding	Anxa2	IPI	RGD:620881	Rat	PMID:18332131\|RGD:2306298
Cellular Component	GO:0005912	adherens junction	ANXA2	HDA		Human	PMID:25468996
Cellular Component	GO:1990665	AnxA2-p11 complex	ANXA2	IDA		Human	PMID:23861394
Cellular Component	GO:0016323	basolateral plasma membrane	Anxa2	IDA		Mouse	MGI:MGI:5446858\|PMID:22848640
Cellular Component	GO:0005938	cell cortex	Anxa2	IDA		Rat	PMID:19193640\|RGD:7242275
Cellular Component	GO:0009986	cell surface	ANXA2	IDA		Human	PMID:10809787
Cellular Component	GO:0009986	cell surface	ANXA2	IDA		Human	PMID:25139904
Cellular Component	GO:0009986	cell surface	Anxa2	IDA		Mouse	PMID:17690254
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ANXA2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ANXA2	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ANXA2	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ANXA2	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Anxa2	HDA		Mouse	MGI:MGI:6201834\|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Anxa2	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0001533	cornified envelope	Anxa2	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005737	cytoplasm	ANXA2	IDA		Human	PMID:21645192
Cellular Component	GO:0005737	cytoplasm	ANXA2	IDA		Human	PMID:25139904
Cellular Component	GO:0005737	cytoplasm	ANXA2	IDA		Human	PMID:26812398
Cellular Component	GO:0005737	cytoplasm	Anxa2	IDA		Mouse	PMID:15078881
Cellular Component	GO:0005737	cytoplasm	Anxa2	IDA		Rat	PMID:14734570\|RGD:1578381
Cellular Component	GO:0005829	cytosol	Anxa2	IDA		Mouse	PMID:16731532
Cellular Component	GO:0005829	cytosol	Anxa2	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0005769	early endosome	Anxa2	IDA		Mouse	PMID:15078881
Cellular Component	GO:0005768	endosome	ANXA2	IDA		Human	PMID:18767904
Cellular Component	GO:0005768	endosome	ANXA2	IDA		Human	PMID:21645192
Cellular Component	GO:0070062	extracellular exosome	ANXA2P2	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	ANXA2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ANXA2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ANXA2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ANXA2	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ANXA2	IDA		Human	PMID:22057634
Cellular Component	GO:0070062	extracellular exosome	ANXA2	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	ANXA2	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	ANXA2	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	Anxa2	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0031902	late endosome membrane	ANXA2	IDA		Human	PMID:23360953
Cellular Component	GO:0005811	lipid droplet	ANXA2	IDA		Human	PMID:14741744
Cellular Component	GO:0005765	lysosomal membrane	ANXA2	IDA		Human	PMID:23360953
Cellular Component	GO:0044354	macropinosome	Anxa2	IDA		Rat	PMID:19193640\|RGD:7242275
Cellular Component	GO:0016020	membrane	ANXA2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Anxa2	IDA		Rat	PMID:23525114\|RGD:12911212
Cellular Component	GO:0045121	membrane raft	ANXA2	IDA		Human	PMID:14699089
Cellular Component	GO:0045121	membrane raft	Anxa2	IDA		Rat	PMID:14499952\|RGD:12793007
Cellular Component	GO:0030496	midbody	ANXA2	IDA		Human	PMID:15166316
Cellular Component	GO:0035749	myelin sheath adaxonal region	Anxa2	IDA		Mouse	MGI:MGI:4441217\|PMID:20237282
Cellular Component	GO:0005634	nucleus	ANXA2	HDA		Human	PMID:21630459
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	ANXA2	IPI		Human	PMID:24808179
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	ANXA2	IDA		Human	PMID:22848640
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Anxa2	IDA		Rat	PMID:14734570\|RGD:1578381
Cellular Component	GO:0005886	plasma membrane	ANXA2	IDA		Human	PMID:18799458
Cellular Component	GO:0005886	plasma membrane	Anxa2	IDA		Rat	PMID:14734570\|RGD:1578381
Cellular Component	GO:0005886	plasma membrane	Anxa2	IDA		Rat	PMID:23525114\|RGD:12911212
Cellular Component	GO:0098797	plasma membrane protein complex	ANXA2	IPI		Human	PMID:23275167
Cellular Component	GO:0098797	plasma membrane protein complex	ANXA2	IPI		Human	PMID:9886297
Cellular Component	GO:0098797	plasma membrane protein complex	Anxa2	EXP		Mouse	MGI:MGI:5469743\|PMID:23415230
Cellular Component	GO:0098797	plasma membrane protein complex	Anxa2	IPI		Mouse	MGI:MGI:5469743\|PMID:23415230
Cellular Component	GO:0032991	protein-containing complex	Anxa2	IDA		Rat	PMID:15823548\|RGD:1600561
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ANXA2	EXP		Human	PMID:23415230
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Anxa2	IPI		Mouse	MGI:MGI:5469743\|PMID:23415230
Cellular Component	GO:0001726	ruffle	Anxa2	IDA		Rat	PMID:19193640\|RGD:7242275
Cellular Component	GO:0042383	sarcolemma	Anxa2	IDA		Mouse	PMID:14506282
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	Anxa2	IDA		Mouse	MGI:MGI:4441217\|PMID:20237282
Cellular Component	GO:0031982	vesicle	ANXA2	HDA		Human	PMID:19190083
Cellular Component	GO:0031982	vesicle	Anxa2	IDA		Rat	PMID:19193640\|RGD:7242275
Biological Process	GO:0001525	angiogenesis	ANXA2	IEP		Human	PMID:11866539
Biological Process	GO:0001525	angiogenesis	Anxa2	IMP	MGI:MGI:3028929	Mouse	PMID:14702107
Biological Process	GO:0007589	body fluid secretion	Anxa2	IMP		Rat	PMID:18332131\|RGD:2306298
Biological Process	GO:0071229	cellular response to acid chemical	Anxa2	IDA		Mouse	PMID:17690254
Biological Process	GO:0030199	collagen fibril organization	Anxa2	IMP	MGI:MGI:3028929	Mouse	PMID:14702107
Biological Process	GO:0042730	fibrinolysis	Anxa2	IMP	MGI:MGI:3028929	Mouse	PMID:14702107
Biological Process	GO:0030299	intestinal cholesterol absorption	anxa2b	IPI	UniProtKB:Q6YLH9	Zfish	PMID:14985510
Biological Process	GO:0030299	intestinal cholesterol absorption	anxa2b	IMP		Zfish	PMID:14985510
Biological Process	GO:0001765	membrane raft assembly	ANXA2	IMP		Human	PMID:23861394
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Anxa2	IDA		Mouse	MGI:MGI:5469743\|PMID:23415230
Biological Process	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	ANXA2	IDA		Human	PMID:22848640
Biological Process	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:0002091	negative regulation of receptor internalization	ANXA2	IDA		Human	PMID:18799458
Biological Process	GO:0036035	osteoclast development	ANXA2	IDA		Human	PMID:7961821
Biological Process	GO:0051099	positive regulation of binding	Anxa2	IMP		Mouse	PMID:17690254
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Anxa2	IMP		Rat	PMID:19193640\|RGD:7242275
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	ANXA2	IDA		Human	PMID:22848640
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	ANXA2	IDA		Human	PMID:22848640
Biological Process	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:1905599	positive regulation of low-density lipoprotein receptor activity	ANXA2	IMP		Human	PMID:22848640
Biological Process	GO:1905599	positive regulation of low-density lipoprotein receptor activity	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:0010756	positive regulation of plasminogen activation	ANXA2	IDA		Human	PMID:9836589
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Anxa2	IMP		Rat	PMID:19193640\|RGD:7242275
Biological Process	GO:0001921	positive regulation of receptor recycling	ANXA2	IDA		Human	PMID:22848640
Biological Process	GO:0001921	positive regulation of receptor recycling	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	ANXA2	IDA		Human	PMID:22848640
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	Anxa2	IMP		Mouse	MGI:MGI:5446858\|PMID:22848640
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Anxa2	IDA		Mouse	MGI:MGI:5469743\|PMID:23415230
Biological Process	GO:0044090	positive regulation of vacuole organization	ANXA2	IMP		Human	PMID:25139904
Biological Process	GO:0031340	positive regulation of vesicle fusion	ANXA2	IDA		Human	PMID:2138016
Biological Process	GO:0072659	protein localization to plasma membrane	Anxa2	IMP		Rat	PMID:19193640\|RGD:7242275
Biological Process	GO:0050767	regulation of neurogenesis	Anxa2	IDA		Mouse	MGI:MGI:5469743\|PMID:23415230
Biological Process	GO:0097066	response to thyroid hormone	Anxa2	IEP		Rat	PMID:9022675\|RGD:2306952
Biological Process	GO:0006900	vesicle budding from membrane	ANXA2	IMP		Human	PMID:23861394

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.