Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AP2A2
  • Mouse genes Ap2a2
  • Rat genes Ap2a2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ap2a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097718	disordered domain specific binding	Ap2a2	IPI	UniProtKB:Q27974	Mouse	MGI:MGI:5882907|PMID:12732633
Molecular Function	GO:0097718	disordered domain specific binding	Ap2a2	IPI	UniProtKB:Q05140	Mouse	MGI:MGI:5882915|PMID:11756460
Molecular Function	GO:0019900	kinase binding	Ap2a2	IPI	UniProtKB:Q16760	Mouse	MGI:MGI:6436414|PMID:17880279
Molecular Function	GO:0035091	phosphatidylinositol binding	Ap2a2	IMP		Rat	PMID:12086608|RGD:12793054
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:Q13286	Human	PMID:15598649
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:Q61743	Human	PMID:16902404
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:O95342	Human	PMID:22262466
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:P98078	Human	PMID:22323290
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:O14672,UniProtKB:O95782,UniProtKB:P63010,UniProtKB:Q96CW1	Human	PMID:23676497
Molecular Function	GO:0005515	protein binding	AP2A2	IPI	UniProtKB:Q6PD74	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	UniProtKB:O35598,UniProtKB:P17426,UniProtKB:P84091,UniProtKB:Q9DBG3	Mouse	MGI:MGI:5514106|PMID:23676497
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	PR:Q8K382	Mouse	PMID:17182770
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	UniProtKB:P21707	Rat	PMID:11502761|RGD:8553705
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	UniProtKB:P62743,UniProtKB:P63010,UniProtKB:P84092	Rat	PMID:12086608|RGD:12793054
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	UniProtKB:O70127	Rat	PMID:22262466|RGD:30309927
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	UniProtKB:P21707	Rat	PMID:9830048|RGD:8553400
Molecular Function	GO:0005515	protein binding	Ap2a2	IPI	RGD:1313643	Rat	PMID:9920862|RGD:9685534
Molecular Function	GO:0019904	protein domain specific binding	Ap2a2	IPI	UniProtKB:A7Z073	Mouse	MGI:MGI:5882907|PMID:12732633
Molecular Function	GO:0019901	protein kinase binding	Ap2a2	IPI	UniProtKB:Q5S007	Mouse	MGI:MGI:4941068|PMID:21307259
Molecular Function	GO:0120283	protein serine/threonine kinase binding	Ap2a2	IPI	RGD:620760	Rat	PMID:20802490|RGD:152995511
Molecular Function	GO:0044877	protein-containing complex binding	Ap2a2	IPI	RGD:1306254	Rat	PMID:23719817|RGD:9491749
Molecular Function	GO:0044877	protein-containing complex binding	Ap2a2	IPI	RGD:620646	Rat	PMID:23719817|RGD:9491749
Cellular Component	GO:0030122	AP-2 adaptor complex	AP2A2	IDA		Human	PMID:23676497
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2a2	IDA		Mouse	MGI:MGI:5514106|PMID:23676497
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2a2	IMP		Rat	PMID:12086608|RGD:12793054
Cellular Component	GO:0031410	cytoplasmic vesicle	Ap2a2	IDA		Mouse	MGI:MGI:5607220|PMID:22174158
Cellular Component	GO:0030117	membrane coat	Ap2a2	IDA		Mouse	PMID:11879655
Cellular Component	GO:0008021	synaptic vesicle	Ap2a2	IDA		Rat	PMID:2072093|RGD:13452390
Biological Process	GO:0072583	clathrin-dependent endocytosis	AP2A2	IMP		Human	PMID:22262466
Biological Process	GO:0072583	clathrin-dependent endocytosis	AP2A2	IDA		Human	PMID:23676497
Biological Process	GO:0072583	clathrin-dependent endocytosis	Ap2a2	IDA		Mouse	MGI:MGI:5514106|PMID:23676497

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern