Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AP2B1
  • Mouse genes Ap2b1
  • Rat genes Ap2b1
  • Zfish genes ap2b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ap2b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030276	clathrin binding	AP2B1	IPI	UniProtKB:P53675	Human	PMID:19509056
Molecular Function	GO:0030276	clathrin binding	AP2B1	IDA		Human	PMID:8262066
Molecular Function	GO:0030276	clathrin binding	Ap2b1	IDA		Rat	PMID:8262066|RGD:2306271
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P18484,UniProtKB:P62743,UniProtKB:P84092	Human	PMID:12086608
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q5SW96	Human	PMID:12221107
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:O00291	Human	PMID:15533940
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q16626	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q5SW96	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q96CW1	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9NVV9	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9Y6Q5	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q15811	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P42566	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P84092	Human	PMID:20603002
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:O14672,UniProtKB:O94973,UniProtKB:O95782,UniProtKB:Q96CW1	Human	PMID:23676497
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9CR95	Human	PMID:24130457
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q96CW1	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P84092	Human	PMID:25061211
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P12236	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P52292	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q01081	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q5SW96	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q8N4L5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q8WWR8-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q99757	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9NVV9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9UHB7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9UHB7-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9Y6Q5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q64729	Human	PMID:26680585
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P12236	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q96CW1	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:A8MWV9	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:O95153	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P42566	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P50542	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P52594	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q14677	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q15811	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q5SW96	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q6ULP2	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q96KG9	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:Q9UJ55	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	AP2B1	IPI	UniProtKB:P84092	Human	PMID:9341158
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:O70161|UniProtKB:O70161	Mouse	MGI:MGI:3703857|PMID:17290217
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:O35598,UniProtKB:P17426,UniProtKB:P17427,UniProtKB:P84091	Mouse	MGI:MGI:5514106|PMID:23676497
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:Q64729	Mouse	MGI:MGI:5755306|PMID:26680585
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:P48023	Mouse	MGI:MGI:5512840|PMID:17761170
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:Q61548	Rat	PMID:10428863|RGD:8553466
Molecular Function	GO:0005515	protein binding	Ap2b1	IPI	UniProtKB:Q3MUI1	Rat	PMID:17022975|RGD:2302412
Molecular Function	GO:0044877	protein-containing complex binding	Ap2b1	IPI	RGD:71066	Rat	PMID:12297494|RGD:633284
Cellular Component	GO:0030122	AP-2 adaptor complex	AP2B1	IMP		Human	PMID:12086608
Cellular Component	GO:0030122	AP-2 adaptor complex	AP2B1	IDA		Human	PMID:23676497
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2b1	IDA		Mouse	MGI:MGI:5514106|PMID:23676497
Cellular Component	GO:0030131	clathrin adaptor complex	AP2B1	IDA		Human	PMID:8262066
Cellular Component	GO:0030118	clathrin coat	Ap2b1	IDA		Rat	PMID:8262066|RGD:2306271
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	Ap2b1	IDA		Rat	PMID:8682861|RGD:155230785
Cellular Component	GO:0098978	glutamatergic synapse	Ap2b1	IDA		Mouse	PMID:24217640
Cellular Component	GO:0098978	glutamatergic synapse	Ap2b1	IMP		Mouse	PMID:24217640
Cellular Component	GO:0098978	glutamatergic synapse	Ap2b1	EXP		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0098978	glutamatergic synapse	Ap2b1	IDA		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0098978	glutamatergic synapse	Ap2b1	IMP		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0016020	membrane	AP2B1	HDA		Human	PMID:19946888
Cellular Component	GO:0045202	synapse	Ap2b1	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Ap2b1	IDA		Mouse	PMID:25211037
Biological Process	GO:0035904	aorta development	Ap2b1	IMP		Mouse	PMID:25807483
Biological Process	GO:0003279	cardiac septum development	Ap2b1	IMP		Mouse	PMID:25807483
Biological Process	GO:0048268	clathrin coat assembly	Ap2b1	IDA		Rat	PMID:8262066|RGD:2306271
Biological Process	GO:0072583	clathrin-dependent endocytosis	AP2B1	IDA		Human	PMID:23676497
Biological Process	GO:0072583	clathrin-dependent endocytosis	Ap2b1	IDA		Mouse	MGI:MGI:5514106|PMID:23676497
Biological Process	GO:0060976	coronary vasculature development	Ap2b1	IMP		Mouse	PMID:25807483
Biological Process	GO:0007507	heart development	Ap2b1	IMP		Mouse	PMID:25807483
Biological Process	GO:0001822	kidney development	Ap2b1	IMP	MGI:MGI:5552944	Mouse	PMID:27002738
Biological Process	GO:1901215	negative regulation of neuron death	Ap2b1	IMP		Rat	PMID:19240038|RGD:13461853
Biological Process	GO:0099590	neurotransmitter receptor internalization	Ap2b1	IMP		Mouse	MGI:MGI:5819335|PMID:24217640
Biological Process	GO:0045807	positive regulation of endocytosis	Ap2b1	IMP		Rat	PMID:19240038|RGD:13461853
Biological Process	GO:1905477	positive regulation of protein localization to membrane	Ap2b1	IMP		Rat	PMID:19240038|RGD:13461853
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2b1	IDA		Mouse	PMID:24217640
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2b1	IMP		Mouse	PMID:24217640
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2b1	EXP		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2b1	IDA		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2b1	IMP		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0048488	synaptic vesicle endocytosis	AP2B1	IDA		Human	PMID:11102472
Biological Process	GO:0048488	synaptic vesicle endocytosis	AP2B1	IMP		Human	PMID:11102472
Biological Process	GO:0003281	ventricular septum development	Ap2b1	IMP		Mouse	PMID:25807483

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern