Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APAF1
  • Mouse genes Apaf1
  • Rat genes Apaf1
  • Zfish genes apaf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apaf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Apaf1	IDA		Mouse	PMID:10830166
Molecular Function	GO:0031072	heat shock protein binding	Apaf1	IPI	RGD:628878	Rat	PMID:22143029|RGD:5686888
Molecular Function	GO:0042802	identical protein binding	Apaf1	IPI	PR:O88879	Mouse	PMID:10830166
Molecular Function	GO:0042802	identical protein binding	Apaf1	IPI	PR:O88879	Mouse	PMID:15907471
Molecular Function	GO:0042802	identical protein binding	Apaf1	IPI	RGD:620575	Rat	PMID:17483091|RGD:2325744
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:10206961
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P99999	Human	PMID:10206961
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:10376594
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:Q9NQS1	Human	PMID:10949025
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P00004	Human	PMID:11112785
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:11821383
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:O43715	Human	PMID:15735003
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P62136	Human	PMID:17274640
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:19494828
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:20462491
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:Q13075	Human	PMID:21371431
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:21827945
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P62258	Human	PMID:22246185
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P99999	Human	PMID:9267021
Molecular Function	GO:0005515	protein binding	APAF1	IPI	UniProtKB:P55211	Human	PMID:9922454
Molecular Function	GO:0005515	protein binding	Apaf1	IPI	UniProtKB:O00291	Rat	PMID:16979168|RGD:8554164
Cellular Component	GO:0043293	apoptosome	APAF1	IPI		Human	PMID:10206961
Cellular Component	GO:0043293	apoptosome	APAF1	IDA		Human	PMID:21827945
Cellular Component	GO:0043293	apoptosome	Apaf1	IDA		Rat	PMID:17483091|RGD:2325744
Cellular Component	GO:0043293	apoptosome	Apaf1	IDA		Rat	PMID:26265044|RGD:11079191
Cellular Component	GO:0005737	cytoplasm	Apaf1	IDA		Rat	PMID:26362957|RGD:13703110
Cellular Component	GO:0005829	cytosol	Apaf1	IDA		Mouse	PMID:15271982
Cellular Component	GO:0070062	extracellular exosome	APAF1	HDA		Human	PMID:19056867
Cellular Component	GO:0005634	nucleus	Apaf1	IDA		Mouse	PMID:15271982
Cellular Component	GO:0032991	protein-containing complex	APAF1	IDA		Human	PMID:11821383
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	APAF1	IDA		Human	PMID:10206961
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	APAF1	IDA		Human	PMID:21827945
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Apaf1	IGI	MGI:MGI:1349414	Mouse	PMID:15703386
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Apaf1	IMP	MGI:MGI:1857868	Mouse	PMID:15703386
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Apaf1	IMP	MGI:MGI:1928692	Mouse	PMID:15776018
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	APAF1	IDA		Human	PMID:10206961
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	APAF1	IDA		Human	PMID:9267021
Biological Process	GO:0007568	aging	Apaf1	IEP		Rat	PMID:18325779|RGD:2325740
Biological Process	GO:0007420	brain development	Apaf1	IMP	MGI:MGI:1928692	Mouse	PMID:9753321
Biological Process	GO:0007420	brain development	Apaf1	IEP		Rat	PMID:11754744|RGD:1299279
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Apaf1	IMP		Rat	PMID:18197610|RGD:2325741
Biological Process	GO:0030154	cell differentiation	Apaf1	IEP		Rat	PMID:15504912|RGD:2325747
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Apaf1	IDA		Rat	PMID:11003619|RGD:2325753
Biological Process	GO:0030900	forebrain development	Apaf1	IMP	MGI:MGI:1888997	Mouse	PMID:9216040
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Apaf1	IMP		Mouse	MGI:MGI:5621265|PMID:16407291
Biological Process	GO:0001822	kidney development	Apaf1	IEP		Rat	PMID:27665619|RGD:13703109
Biological Process	GO:0007275	multicellular organism development	Apaf1	IMP	MGI:MGI:1857868	Mouse	PMID:9753320
Biological Process	GO:0001843	neural tube closure	Apaf1	IMP	MGI:MGI:1888997	Mouse	PMID:9216040
Biological Process	GO:0001843	neural tube closure	Apaf1	IMP	MGI:MGI:1888997	Mouse	PMID:11504943
Biological Process	GO:0051402	neuron apoptotic process	Apaf1	IGI	MGI:MGI:1349414	Mouse	PMID:15703386
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Apaf1	IGI	MGI:MGI:1889507	Mouse	PMID:16183742
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	Apaf1	IGI	MGI:MGI:1349414	Mouse	PMID:15703386
Biological Process	GO:0001666	response to hypoxia	Apaf1	IEP		Rat	PMID:18325779|RGD:2325740
Biological Process	GO:0007584	response to nutrient	Apaf1	IEP		Rat	PMID:14973070|RGD:2325748

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern