Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APELA
  • Mouse genes Apela
  • Rat genes
  • Zfish genes apela
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apela

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031704	apelin receptor binding	APELA	IDA		Human	PMID:28137936
Molecular Function	GO:0031704	apelin receptor binding	apela	IDA		Zfish	PMID:24316148
Molecular Function	GO:0031704	apelin receptor binding	apela	IDA		Zfish	PMID:24407481
Molecular Function	GO:0005179	hormone activity	APELA	IMP		Human	PMID:25639753
Molecular Function	GO:0005179	hormone activity	APELA	IMP		Human	PMID:28137936
Molecular Function	GO:0005179	hormone activity	apela	IMP		Zfish	PMID:24316148|ZFIN:ZDB-PUB-140106-3
Cellular Component	GO:0005576	extracellular region	APELA	IDA		Human	PMID:24316148
Cellular Component	GO:0005576	extracellular region	APELA	IDA		Human	PMID:28137936
Cellular Component	GO:0005615	extracellular space	Apela	IDA		Mouse	MGI:MGI:5913613|PMID:28663440
Cellular Component	GO:0005615	extracellular space	apela	IDA		Zfish	PMID:24407481
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	apela	IGI	ZFIN:ZDB-GENE-070521-8	Zfish	PMID:26017639
Biological Process	GO:0035479	angioblast cell migration from lateral mesoderm to midline	apela	IMP	ZFIN:ZDB-GENO-151105-3	Zfish	PMID:26017639
Biological Process	GO:0060183	apelin receptor signaling pathway	APELA	IDA		Human	PMID:25639753
Biological Process	GO:0060183	apelin receptor signaling pathway	APELA	IMP		Human	PMID:28137936
Biological Process	GO:0060183	apelin receptor signaling pathway	apela	IMP		Zfish	PMID:24316148|ZFIN:ZDB-PUB-140106-3
Biological Process	GO:0060183	apelin receptor signaling pathway	apela	IDA		Zfish	PMID:24407481|ZFIN:ZDB-PUB-140317-12
Biological Process	GO:0060183	apelin receptor signaling pathway	apela	IDA		Zfish	PMID:24407481
Biological Process	GO:0042074	cell migration involved in gastrulation	apela	IMP	ZFIN:ZDB-GENO-140611-4	Zfish	PMID:24407481
Biological Process	GO:0090134	cell migration involved in mesendoderm migration	apela	IMP		Zfish	PMID:24407481|ZFIN:ZDB-PUB-140317-12
Biological Process	GO:0090134	cell migration involved in mesendoderm migration	apela	IGI	ZFIN:ZDB-GENE-070521-8,ZFIN:ZDB-GENO-140611-4	Zfish	PMID:24407481
Biological Process	GO:0090134	cell migration involved in mesendoderm migration	apela	IDA		Zfish	PMID:24407481
Biological Process	GO:0043009	chordate embryonic development	apela	IMP	ZFIN:ZDB-GENO-140611-4	Zfish	PMID:24407481
Biological Process	GO:0043009	chordate embryonic development	apela	IMP	ZFIN:ZDB-GENO-140625-2	Zfish	PMID:24407481
Biological Process	GO:0060976	coronary vasculature development	Apela	IMP		Mouse	MGI:MGI:5914956|PMID:28890073
Biological Process	GO:0061371	determination of heart left/right asymmetry	apela	IMP	ZFIN:ZDB-MRPHLNO-191209-4	Zfish	PMID:31223282
Biological Process	GO:0007368	determination of left/right symmetry	apela	IMP	ZFIN:ZDB-MRPHLNO-191209-4	Zfish	PMID:31223282
Biological Process	GO:0071910	determination of liver left/right asymmetry	apela	IMP	ZFIN:ZDB-MRPHLNO-191209-4	Zfish	PMID:31223282
Biological Process	GO:0035050	embryonic heart tube development	Apela	IMP		Mouse	MGI:MGI:5913613|PMID:28663440
Biological Process	GO:0035050	embryonic heart tube development	Apela	IMP		Mouse	MGI:MGI:5909243|PMID:28854362
Biological Process	GO:0007492	endoderm development	apela	IMP		Zfish	PMID:24316148|ZFIN:ZDB-PUB-140106-3
Biological Process	GO:0035987	endodermal cell differentiation	apela	IMP	ZFIN:ZDB-GENO-140116-10	Zfish	PMID:24316148
Biological Process	GO:0007507	heart development	apela	IMP		Zfish	PMID:24316148|ZFIN:ZDB-PUB-140106-3
Biological Process	GO:0070121	Kupffer's vesicle development	apela	IMP	ZFIN:ZDB-MRPHLNO-191209-4	Zfish	PMID:31223282
Biological Process	GO:0090133	mesendoderm migration	apela	IMP		Zfish	PMID:24407481|ZFIN:ZDB-PUB-140317-12
Biological Process	GO:0007509	mesoderm migration involved in gastrulation	apela	IMP		Zfish	PMID:29117894|ZFIN:ZDB-PUB-171110-5
Biological Process	GO:0007509	mesoderm migration involved in gastrulation	apela	IMP	ZFIN:ZDB-GENO-180920-19	Zfish	PMID:29117894
Biological Process	GO:0007509	mesoderm migration involved in gastrulation	apela	IMP	ZFIN:ZDB-GENO-180920-18	Zfish	PMID:29117894
Biological Process	GO:0060674	placenta blood vessel development	Apela	IMP		Mouse	MGI:MGI:5913613|PMID:28663440
Biological Process	GO:0045766	positive regulation of angiogenesis	APELA	IMP		Human	PMID:25639753
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	Apela	IMP		Mouse	MGI:MGI:5914956|PMID:28890073
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	APELA	IMP		Human	PMID:25639753
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	APELA	IMP		Human	PMID:28663440
Biological Process	GO:0060395	SMAD protein signal transduction	Apela	IDA		Mouse	PMID:23390484
Biological Process	GO:0002040	sprouting angiogenesis	apela	IGI	ZFIN:ZDB-GENO-151105-15	Zfish	PMID:32955436
Biological Process	GO:0001570	vasculogenesis	Apela	IMP		Mouse	MGI:MGI:5913613|PMID:28663440
Biological Process	GO:0001570	vasculogenesis	Apela	IMP		Mouse	MGI:MGI:5909243|PMID:28854362

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern