Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APEX1
  • Mouse genes Apex1
  • Rat genes Apex1
  • Zfish genes apex1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Apex1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	APEX1	IDA		Human	PMID:11832948
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	APEX1	IDA		Human	PMID:1627644
Molecular Function	GO:0031490	chromatin DNA binding	APEX1	IDA		Human	PMID:11809897
Molecular Function	GO:0052720	class II DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:11160897
Molecular Function	GO:0052720	class II DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:11286553
Molecular Function	GO:0052720	class II DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:1627644
Molecular Function	GO:0052720	class II DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:9804798
Molecular Function	GO:0003684	damaged DNA binding	APEX1	IDA		Human	PMID:12524539
Molecular Function	GO:0003684	damaged DNA binding	APEX1	IDA		Human	PMID:14706345
Molecular Function	GO:0003684	damaged DNA binding	APEX1	IDA		Human	PMID:24703901
Molecular Function	GO:0003677	DNA binding	APEX1	IDA		Human	PMID:11286553
Molecular Function	GO:0140431	DNA-(abasic site) binding	APEX1	IMP		Human	PMID:9804798
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:15707971
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:18973764
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:19188445
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:24703901
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	APEX1	IDA		Human	PMID:8932386
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	apex1	IDA		Zfish	PMID:33842455
Molecular Function	GO:0008309	double-stranded DNA exodeoxyribonuclease activity	APEX1	IDA		Human	PMID:24703901
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	APEX1	IDA		Human	PMID:24703901
Molecular Function	GO:0004519	endonuclease activity	APEX1	IDA		Human	PMID:11478795
Molecular Function	GO:0046872	metal ion binding	APEX1	IDA		Human	PMID:11286553
Molecular Function	GO:0051059	NF-kappaB binding	Apex1	IDA		Rat	PMID:17602955|RGD:2315672
Molecular Function	GO:0016491	oxidoreductase activity	APEX1	IDA		Human	PMID:12524539
Molecular Function	GO:0016491	oxidoreductase activity	APEX1	IDA		Human	PMID:9119221
Molecular Function	GO:0090580	phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	APEX1	IDA		Human	PMID:1627644
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	APEX1	IDA		Human	PMID:11478795
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	APEX1	IDA		Human	PMID:18973764
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P10599	Human	PMID:11118054
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P14866	Human	PMID:11809897
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P12544	Human	PMID:12524539
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P23396	Human	PMID:15518571
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P52292	Human	PMID:15942031
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P52294	Human	PMID:15942031
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P67809	Human	PMID:18809583
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q14764	Human	PMID:18809583
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P05388	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P05787	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P06748	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P30041	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q9BQA1	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q9UMS4	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P52926	Human	PMID:19465398
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q01664	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P18887	Human	PMID:19934257
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q96EB6	Human	PMID:19934257
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q15388	Human	PMID:20231292
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:O88846	Human	PMID:20696907
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q09472	Human	PMID:20808282
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q09472	Human	PMID:20856196
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P12956	Human	PMID:8621488
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P13010	Human	PMID:8621488
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P10599	Human	PMID:9108029
Molecular Function	GO:0005515	protein binding	APEX1	IPI	UniProtKB:P06746	Human	PMID:9207062
Molecular Function	GO:0005515	protein binding	Apex1	IPI	RGD:727889	Rat	PMID:17280489|RGD:2315673
Molecular Function	GO:0044877	protein-containing complex binding	Apex1	IPI	RGD:620036|RGD:61928	Rat	PMID:15084519|RGD:2312278
Molecular Function	GO:0003723	RNA binding	APEX1	HDA		Human	PMID:22681889
Molecular Function	GO:0004521	RNA endonuclease activity	Apex1	IDA		Rat	PMID:19401441|RGD:2315668
Molecular Function	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	APEX1	IDA		Human	PMID:19188445
Molecular Function	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	APEX1	IDA		Human	PMID:24703901
Molecular Function	GO:0003713	transcription coactivator activity	APEX1	IDA		Human	PMID:18809583
Molecular Function	GO:0003713	transcription coactivator activity	APEX1	IDA		Human	PMID:9119221
Cellular Component	GO:0005813	centrosome	APEX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	APEX1	IDA		Human	PMID:9560228
Cellular Component	GO:0005737	cytoplasm	Apex1	IDA		Mouse	PMID:14594818
Cellular Component	GO:0005737	cytoplasm	Apex1	IDA		Rat	PMID:12173070|RGD:634652
Cellular Component	GO:0005739	mitochondrion	APEX1	IDA		Human	PMID:20231292
Cellular Component	GO:0005739	mitochondrion	Apex1	IDA		Rat	PMID:11182545|RGD:2315683
Cellular Component	GO:0016607	nuclear speck	APEX1	IDA		Human	PMID:17148573
Cellular Component	GO:0005730	nucleolus	APEX1	IDA		Human	PMID:17148573
Cellular Component	GO:0005730	nucleolus	APEX1	IDA		Human	PMID:19188445
Cellular Component	GO:0005654	nucleoplasm	APEX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	APEX1	IDA		Human	PMID:17148573
Cellular Component	GO:0005634	nucleus	APEX1	IDA		Human	PMID:15942031
Cellular Component	GO:0005634	nucleus	APEX1	IDA		Human	PMID:19934257
Cellular Component	GO:0005634	nucleus	APEX1	IDA		Human	PMID:9119221
Cellular Component	GO:0005634	nucleus	APEX1	IDA		Human	PMID:28404743
Cellular Component	GO:0005634	nucleus	Apex1	IDA		Mouse	PMID:14594818
Cellular Component	GO:0005634	nucleus	Apex1	IDA		Rat	PMID:12173070|RGD:634652
Cellular Component	GO:0048471	perinuclear region of cytoplasm	APEX1	IDA		Human	PMID:12524539
Cellular Component	GO:0005667	transcription regulator complex	Apex1	IDA		Rat	PMID:15084519|RGD:2312278
Biological Process	GO:0007568	aging	Apex1	IDA		Rat	PMID:12742531|RGD:2315679
Biological Process	GO:0006284	base-excision repair	APEX1	IDA		Human	PMID:8932386
Biological Process	GO:0045454	cell redox homeostasis	Apex1	IDA		Mouse	PMID:14594818
Biological Process	GO:0071320	cellular response to cAMP	Apex1	IEP		Rat	PMID:12173070|RGD:634652
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Apex1	IEP		Rat	PMID:12173070|RGD:634652
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Apex1	IDA		Rat	PMID:12884291|RGD:2315678
Biological Process	GO:0071417	cellular response to organonitrogen compound	Apex1	IEP		Rat	PMID:12173070|RGD:634652
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Apex1	IEP		Rat	PMID:12173070|RGD:634652
Biological Process	GO:0006308	DNA catabolic process	APEX1	IDA		Human	PMID:1627644
Biological Process	GO:0080111	DNA demethylation	APEX1	IDA		Human	PMID:21496894
Biological Process	GO:0006281	DNA repair	APEX1	IDA		Human	PMID:1627644
Biological Process	GO:0006281	DNA repair	APEX1	IDA		Human	PMID:9560228
Biological Process	GO:0060047	heart contraction	apex1	IMP	ZFIN:ZDB-MRPHLNO-070619-1,ZFIN:ZDB-MRPHLNO-070619-2,ZFIN:ZDB-MRPHLNO-070619-3	Zfish	PMID:16966376
Biological Process	GO:0001947	heart looping	apex1	IMP	ZFIN:ZDB-MRPHLNO-070619-1,ZFIN:ZDB-MRPHLNO-070619-2,ZFIN:ZDB-MRPHLNO-070619-3	Zfish	PMID:16966376
Biological Process	GO:0043066	negative regulation of apoptotic process	apex1	IMP	ZFIN:ZDB-MRPHLNO-070619-1,ZFIN:ZDB-MRPHLNO-070619-2,ZFIN:ZDB-MRPHLNO-070619-3	Zfish	PMID:16966376
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	Apex1	IMP		Rat	PMID:19038866|RGD:2315669
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Apex1	IMP		Rat	PMID:12730053|RGD:2315680
Biological Process	GO:0010628	positive regulation of gene expression	apex1	IMP	ZFIN:ZDB-MRPHLNO-070619-4	Zfish	PMID:21172930
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	APEX1	IDA		Human	PMID:18809583
Biological Process	GO:0042981	regulation of apoptotic process	APEX1	IDA		Human	PMID:19934257
Biological Process	GO:0043488	regulation of mRNA stability	APEX1	IMP		Human	PMID:19401441
Biological Process	GO:0010243	response to organonitrogen compound	Apex1	IEP		Rat	PMID:15344903|RGD:2315676
Biological Process	GO:0009410	response to xenobiotic stimulus	Apex1	IEP		Rat	PMID:17264098|RGD:2314327
Biological Process	GO:0000723	telomere maintenance	APEX1	IDA		Human	PMID:24703901
Biological Process	GO:0097698	telomere maintenance via base-excision repair	APEX1	IDA		Human	PMID:24703901

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern