Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APH1A
  • Mouse genes Aph1a
  • Rat genes Aph1a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aph1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	APH1A	IMP		Human	PMID:12297508
Molecular Function	GO:0061133	endopeptidase activator activity	APH1A	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Molecular Function	GO:0061133	endopeptidase activator activity	Aph1a	IMP		Mouse	MGI:MGI:6478051|PMID:12522139
Molecular Function	GO:0019899	enzyme binding	Aph1a	IPI	UniProtKB:P49769	Mouse	MGI:MGI:6478051|PMID:12522139
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P49768	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P49810	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q92542	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q92542	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q92542	Human	PMID:19376115
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q92542	Human	PMID:26280335
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:A2RU14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:O43561-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P05090	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P07306	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P24593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P57086	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q00013	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q0VAQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q6ZSS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q86W74-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q96G30	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9H0Q3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9NUM3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9NV12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9NVC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9Y3D6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q9Y6X1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:P06241	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APH1A	IPI	UniProtKB:Q15438	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	PR:P49769	Mouse	PMID:21597003
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	PR:Q9CQR7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	PR:Q61144	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	PR:P49769	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	PR:P57716	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Aph1a	IPI	RGD:2937	Rat	PMID:20145246|RGD:7242200
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	APH1A	IMP		Human	PMID:12297508
Cellular Component	GO:0005769	early endosome	Aph1a	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0005783	endoplasmic reticulum	APH1A	IDA		Human	PMID:15274632
Cellular Component	GO:0070765	gamma-secretase complex	APH1A	IPI		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	APH1A	IDA		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	APH1A	IDA		Human	PMID:25043039
Cellular Component	GO:0070765	gamma-secretase complex	APH1A	IDA		Human	PMID:26280335
Cellular Component	GO:0005794	Golgi apparatus	APH1A	IDA		Human	PMID:15274632
Cellular Component	GO:0016020	membrane	APH1A	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	APH1A	IDA		Human	PMID:25043039
Cellular Component	GO:0016020	membrane	APH1A	IDA		Human	PMID:26280335
Cellular Component	GO:0005739	mitochondrion	Aph1a	IDA		Rat	PMID:15456764|RGD:1358417
Cellular Component	GO:0005886	plasma membrane	APH1A	IDA		Human	PMID:15274632
Cellular Component	GO:0005886	plasma membrane	Aph1a	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0042734	presynaptic membrane	Aph1a	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0097060	synaptic membrane	Aph1a	IDA		Rat	PMID:20126630|RGD:13702254
Cellular Component	GO:0008021	synaptic vesicle	Aph1a	IDA		Rat	PMID:20126630|RGD:13702254
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1A	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1A	IDA		Human	PMID:15274632
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1A	IDA		Human	PMID:27608597
Biological Process	GO:0042982	amyloid precursor protein metabolic process	APH1A	IDA		Human	PMID:25043039
Biological Process	GO:0042982	amyloid precursor protein metabolic process	APH1A	IDA		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0034205	amyloid-beta formation	APH1A	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0034205	amyloid-beta formation	APH1A	IMP		Human	PMID:25043039
Biological Process	GO:0034205	amyloid-beta formation	APH1A	IMP		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	APH1A	IDA		Human	PMID:27608597
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	APH1A	IDA		Human	PMID:15274632
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0031293	membrane protein intracellular domain proteolysis	APH1A	IDA		Human	PMID:15274632
Biological Process	GO:0001656	metanephros development	Aph1a	IMP		Mouse	PMID:12952904
Biological Process	GO:0007220	Notch receptor processing	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0007220	Notch receptor processing	APH1A	IDA		Human	PMID:27608597
Biological Process	GO:0007220	Notch receptor processing	Aph1a	IMP		Mouse	PMID:20130175
Biological Process	GO:0043085	positive regulation of catalytic activity	APH1A	IDA		Human	PMID:15274632
Biological Process	GO:0010950	positive regulation of endopeptidase activity	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0010950	positive regulation of endopeptidase activity	APH1A	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0010950	positive regulation of endopeptidase activity	Aph1a	IMP		Mouse	MGI:MGI:6478051|PMID:12522139
Biological Process	GO:0016485	protein processing	APH1A	IMP		Human	PMID:12297508
Biological Process	GO:0016485	protein processing	APH1A	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	APH1A	IDA		Human	PMID:15274632
Biological Process	GO:0016485	protein processing	APH1A	IDA		Human	PMID:27608597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern