Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes APH1B
  • Mouse genes Aph1c
  • Rat genes Aph1b
  • Zfish genes aph1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aph1c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	APH1B	IMP		Human	PMID:12297508
Molecular Function	GO:0061133	endopeptidase activator activity	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:P49768	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:P49810	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:P48230	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:Q6UX27-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	APH1B	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	APH1B	IMP		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	APH1B	IDA		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Cellular Component	GO:0070765	gamma-secretase complex	Aph1c	IDA		Mouse	PMID:19299585
Cellular Component	GO:0016020	membrane	APH1B	IDA		Human	PMID:12297508
Cellular Component	GO:0045202	synapse	Aph1c	IGI	MGI:MGI:3522097	Mouse	MGI:MGI:3804503|PMID:18626010
Cellular Component	GO:0030133	transport vesicle	APH1B	IDA		Human	GO_REF:0000054
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0042987	amyloid precursor protein catabolic process	APH1B	IDA		Human	PMID:27608597
Biological Process	GO:0034205	amyloid-beta formation	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0034205	amyloid-beta formation	APH1B	IDA		Human	PMID:27608597
Biological Process	GO:0007626	locomotory behavior	Aph1b	IMP		Rat	PMID:15721236|RGD:13703127
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Aph1c	IGI	MGI:MGI:3522097	Mouse	PMID:18626010
Biological Process	GO:0001656	metanephros development	Aph1c	IMP		Mouse	PMID:12952904
Biological Process	GO:0007220	Notch receptor processing	APH1B	IDA		Human	PMID:27608597
Biological Process	GO:0010950	positive regulation of endopeptidase activity	APH1B	IMP		Human	PMID:12297508
Biological Process	GO:0010950	positive regulation of endopeptidase activity	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0060134	prepulse inhibition	Aph1c	IGI	MGI:MGI:3522097	Mouse	PMID:18626010
Biological Process	GO:0016485	protein processing	APH1B	IDA		Human	PMID:12297508
Biological Process	GO:0016485	protein processing	APH1B	IGI	UniProtKB:P05067|UniProtKB:P49768	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	APH1B	IDA		Human	PMID:27608597
Biological Process	GO:0016485	protein processing	Aph1c	IGI	MGI:MGI:2385110	Mouse	PMID:15634781
Biological Process	GO:0007614	short-term memory	Aph1c	IGI	MGI:MGI:3522097	Mouse	PMID:18626010
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Aph1c	IGI	MGI:MGI:3522097	Mouse	PMID:18626010
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Aph1c	IGI	MGI:MGI:3522097	Mouse	PMID:18626010

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern